APOA4

Gene Information
 
Gene Symbol
APOA4
 
Aliases
-
 
Entrez Gene ID
337
 
Gene Name
Apolipoprotein A4
 
Chromosomal Location
11q23.3
 
HGNC ID
 
Summary
Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0002227 Biological process Innate immune response in mucosa IDA 15254593
GO:0006695 Biological process Cholesterol biosynthetic process IBA 21873635
GO:0006869 Biological process Lipid transport IDA 1935934, 3095477
GO:0006982 Biological process Response to lipid hydroperoxide IDA 16945374
GO:0007159 Biological process Leukocyte cell-cell adhesion IDA 15254593
Protein Information
 
Protein Name
Apolipoprotein A-IV, apo-AIV, apoA-IV
 
Function
 
Refseq Proteins
Pathways
 
KEGG
 
 

Fat digestion and absorption
Vitamin digestion and absorption
Cholesterol metabolism

 

Interactions
 
STRING MINT IntAct
ENSP00000336790 P18848 P18848
    View interactions
     

Associated Diseases

Disease groupDisease NameReferences
Cardiovascular Diseases
Atherosclerosis
Endocrine System Diseases
PCOS
Nutritional and Metabolic Diseases
Hyperlipoproteinemia
Hypercholesterolemia
Psychiatric/Brain disorders
Schizophrenia
References
 
 
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
kininogen1(KNG1), cytokeratin9(KRT9), antithrombin, fibrinogen ?-chain(FGG), ?-1-B-glycoprotein (A1BG) 
PCOS 
 
 
Direct 
5 normal, 5 PCOS patients 
Protein expression levels of apoA-IV precursor and A1BG were increased in follicular fluid from PCOS patients compared with those from normal controls. The analysis of protein expression for other proteins revealed individual variation. 

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