CD14

Gene Information
 
Gene Symbol
CD14
 
Aliases
-
 
Entrez Gene ID
929
 
Gene Name
CD14 molecule
 
Chromosomal Location
5q31.3
 
HGNC ID
 
Summary
The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0006909 Biological process Phagocytosis TAS 9548256
GO:0006915 Biological process Apoptotic process TAS 9548256
GO:0006954 Biological process Inflammatory response IBA 21873635
GO:0007166 Biological process Cell surface receptor signaling pathway TAS 8798531
GO:0031663 Biological process Lipopolysaccharide-mediated signaling pathway IBA 21873635
Protein Information
 
Protein Name
Monocyte differentiation antigen CD14, myeloid cell-specific leucine-rich glycoprotein
 
Function
Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-)
 
Refseq Proteins
 
UniProt
 
PDB
Pathways
 
KEGG
 
Reactome
 

MAPK signaling pathway
NF-kappa B signaling pathway
Phagosome
Toll-like receptor signaling pathway
Hematopoietic cell lineage
Pathogenic Escherichia coli infection
Salmonella infection
Pertussis
Legionellosis
Amoebiasis
Tuberculosis
Transcriptional misregulation in cancer
Acute myeloid leukemia

 

ER-Phagosome pathway
Caspase activation via Death Receptors in the presence of ligand
Toll Like Receptor 4 (TLR4) Cascade
Transfer of LPS from LBP carrier to CD14
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
MyD88-independent TLR4 cascade
Toll Like Receptor TLR1:TLR2 Cascade
Toll Like Receptor TLR6:TLR2 Cascade
TRIF-mediated programmed cell death
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Regulation of TLR by endogenous ligand
Neutrophil degranulation
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
TRAF6-mediated induction of TAK1 complex within TLR4 complex
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

Interactions
 
STRING MINT IntAct
ENSP00000304236 P08571 P08571
    View interactions
     

Associated Diseases

Disease groupDisease NameReferences
Blood Disorders
Anemia
Blood Coagulation Disorders
Kawasaki disease
Thrombocytopenia
Cardiovascular Diseases
Cardiovascular Abnormalities