CPB2: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

CPB2

Aliases

CPU, PCPB, TAFI

Entrez Gene ID

1361

Gene Name

Carboxypeptidase B2

Chromosomal Location

13q14.13

HGNC ID

HGNC:2300

Summary

Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

RefSeq DNA

NG_032893.2

RefSeq mRNA

NM_001872.5, NM_001278541.1

e!Ensembl

Gene	ENSG00000080618
Transcript	ENST00000181383, ENST00000439329
Protein	ENSP00000181383, ENSP00000400714

Gene Ontology (GO)

Show/Hide all(5 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006508	Biological process	Proteolysis	IBA	21873635
GO:0042730	Biological process	Fibrinolysis	IBA	21873635
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0070062	Cellular component	Extracellular exosome	HDA	23533145
GO:0004181	Molecular function	Metallocarboxypeptidase activity	IBA	21873635

Protein Information

Protein Name

Carboxypeptidase B2, carboxypeptidase B-like protein, carboxypeptidase B2 (plasma), carboxypeptidase B2 (plasma, carboxypeptidase U), carboxypeptidase R, thrombin-activable fibrinolysis inhibitor, thrombin-activatable fibrinolysis inhibitor

Function

Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.

Refseq Proteins

NP_001863.3, NP_001265470.1

UniProt

Q96IY4

PDB

3D66, 3D67, 3D68, 3LMS, 4P10, 5HVF, 5HVG, 5HVH

Pfam

Pfam Accession	Pfam ID
PF00246	Peptidase_M14
PF02244	Propep_M14