FOXO3

Gene Information
 
Gene Symbol
FOXO3
 
Aliases
AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A
 
Entrez Gene ID
 
Gene Name
Forkhead box O3
 
Chromosomal Location
6q21
 
HGNC ID
 
Summary
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0000122 Biological process Negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0000122 Biological process Negative regulation of transcription by RNA polymerase II IDA 20371612
GO:0000122 Biological process Negative regulation of transcription by RNA polymerase II IMP 18787191
GO:0006390 Biological process Mitochondrial transcription IMP 29445193
GO:0006417 Biological process Regulation of translation IDA 21329882
Protein Information
 
Protein Name
Forkhead box protein O3, forkhead box O3A, forkhead homolog (rhabdomyosarcoma) like 1, forkhead in rhabdomyosarcoma-like 1, forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
 
Function
 
UniProt