ICAM1

Gene Information
 
Gene Symbol
ICAM1
 
Aliases
BB2, CD54, P3.58
 
Entrez Gene ID
 
Gene Name
Intercellular adhesion molecule 1
 
Chromosomal Location
19p13.2
 
HGNC ID
 
Summary
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0001910 Biological process Regulation of leukocyte mediated cytotoxicity TAS 16038038
GO:0002291 Biological process T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP 2477710
GO:0002693 Biological process Positive regulation of cellular extravasation IMP 12902516
GO:0007155 Biological process Cell adhesion IBA 21873635
GO:0007155 Biological process Cell adhesion IDA 16809613
Protein Information
 
Protein Name
Intercellular adhesion molecule 1, ICAM-1, cell surface glycoprotein P3.58, epididymis secretory sperm binding protein, intercellular adhesion molecule 1 (CD54), human rhinovirus receptor, major group rhinovirus receptor
 
Function
 
Refseq Proteins
 
UniProt
 
PDB
 
Pfam
Pfam Accession Pfam ID
PF03921 ICAM_N
Pathways
 
KEGG
 
Reactome
 

NF-kappa B signaling pathway
Cell adhesion molecules (CAMs)
Natural killer cell mediated cytotoxicity
TNF signaling pathway
Leukocyte transendothelial migration
AGE-RAGE signaling pathway in diabetic complications
African trypanosomiasis
Malaria
Staphylococcus aureus infection
Influenza A
Human T-cell leukemia virus 1 infection
Kaposi sarcoma-associated herpesvirus infection
Epstein-Barr virus infection
Rheumatoid arthritis
Viral myocarditis
Fluid shear stress and atherosclerosis

 

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Integrin cell surface interactions
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling

Interactions
 
STRING MINT IntAct
ENSP00000370842 O95760 O95760
    View interactions
     

Associated Diseases

Disease groupDisease NameReferences