IL17A

Gene Information
 
Gene Symbol
IL17A
 
Aliases
CTLA-8, CTLA8, IL-17, IL-17A, IL17
 
Entrez Gene ID
 
Gene Name
Interleukin 17A
 
Chromosomal Location
6p12.2
 
HGNC ID
 
Summary
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0006915 Biological process Apoptotic process TAS 7499828
GO:0006955 Biological process Immune response TAS 7499828
GO:0007267 Biological process Cell-cell signaling TAS 7499828
GO:0008219 Biological process Cell death TAS 8390535
GO:0032747 Biological process Positive regulation of interleukin-23 production IDA 21145111
Protein Information
 
Protein Name
Interleukin-17A, cytotoxic T-lymphocyte-associated antigen 8, cytotoxic T-lymphocyte-associated protein 8, interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
 
Function
Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).
 
Refseq Proteins
 
UniProt
 
PDB
 
Pfam
Pfam Accession Pfam ID
PF06083 IL17
Pathways
 
KEGG
 
Reactome
 

Cytokine-cytokine receptor interaction
IL-17 signaling pathway
Th17 cell differentiation
Inflammatory bowel disease (IBD)
Rheumatoid arthritis

 

Interleukin-17 signaling
Interleukin-4 and Interleukin-13 signaling

Interactions
 
STRING MINT IntAct
ENSP00000369442 Q9UEF7
    View interactions
     

Associated Diseases

Disease groupDisease NameReferences
Digestive System Diseases
Liver Diseases
Hepatitis
Colitis
Endocrine System Diseases
PCOS
Immune System Diseases
Lymphoproliferative Disorder
References
 
 
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
ADAMTS1, ADAMTS5, ADAMTS9, IL?23, IL?33,CRP, TNF-?, IL-1, IL-6, IL-18, ADAMTS16, IL-5 
Insulin resistance, impaired glucose tolerance (IGT), type 2 diabetes mellitus (DM type 2) , metabolic syndrome, malignancy and cardiovascular diseases. 
 
Rotterdam criteria 
Direct 
43 patients undergoing IVF treatment21 diagnosed as PCOS and 22 diagnosed as normal ovulatory women (the control group) 
ADAMTS and IL molecules have a role in the pathogenesis of the PCOS. 

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