IL23A

Gene Information
 
Gene Symbol
IL23A
 
Aliases
IL-23, IL-23A, IL23P19, P19, SGRF
 
Entrez Gene ID
 
Gene Name
Interleukin 23 subunit alpha
 
Chromosomal Location
12q13.3
 
HGNC ID
 
Summary
This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0002230 Biological process Positive regulation of defense response to virus by host IDA 12421946
GO:0002827 Biological process Positive regulation of T-helper 1 type immune response IDA 15114670
GO:0002827 Biological process Positive regulation of T-helper 1 type immune response NAS 20027291
GO:0002827 Biological process Positive regulation of T-helper 1 type immune response TAS 16751425
GO:0010536 Biological process Positive regulation of activation of Janus kinase activity IBA 21873635
Protein Information
 
Protein Name
Interleukin-23 subunit alpha, IL-23 subunit alpha, IL-23-A, IL-23p19, JKA3 induced upon T-cell activation, interleukin 23 p19 subunit, interleukin 23, alpha subunit p19, interleukin-23 subunit p19, interleukin-six, G-CSF related factor
 
Function
Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
 
UniProt
 
PDB
 
Pfam
Pfam Accession Pfam ID
PF16649 IL23
Pathways
 
KEGG
 
Reactome
 

Cytokine-cytokine receptor interaction
C-type lectin receptor signaling pathway
JAK-STAT signaling pathway
Th17 cell differentiation
Pertussis
Tuberculosis
Pathways in cancer
Inflammatory bowel disease (IBD)
Rheumatoid arthritis

 

Interleukin-4 and Interleukin-13 signaling
Interleukin-23 signaling

Interactions
 
STRING MINT IntAct
ENSP00000217407 P18428
    View interactions
     

Associated Diseases

Disease groupDisease NameReferences
Endocrine System Diseases
PCOS
Immune System Diseases
Rheumatoid Arthritis
Skin and Connective Tissue Diseases
Pustulosis
Psoriasis
References
 
 
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
ADAMTS1, ADAMTS5, ADAMTS9, IL?17A, IL?33,CRP, TNF-?, IL-1, IL-6, IL-18, ADAMTS16, IL-6 
Insulin resistance, impaired glucose tolerance (IGT), type 2 diabetes mellitus (DM type 2) , metabolic syndrome, malignancy and cardiovascular diseases. 
 
Rotterdam criteria 
Direct 
43 patients undergoing IVF treatment21 diagnosed as PCOS and 22 diagnosed as normal ovulatory women (the control group) 
ADAMTS and IL molecules have a role in the pathogenesis of the PCOS. 

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