IL33

Gene Information
 
Gene Symbol
IL33
 
Aliases
C9orf26, DVS27, IL1F11, NF-HEV, NFEHEV
 
Entrez Gene ID
 
Gene Name
Interleukin 33
 
Chromosomal Location
9p24.1
 
HGNC ID
 
Summary
The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0043032 Biological process Positive regulation of macrophage activation IDA 19841166
GO:0045944 Biological process Positive regulation of transcription by RNA polymerase II ISS 19841166
GO:0050729 Biological process Positive regulation of inflammatory response IBA 21873635
GO:0050729 Biological process Positive regulation of inflammatory response ISS 19841166
GO:0090197 Biological process Positive regulation of chemokine secretion IDA 19841166
Protein Information
 
Protein Name
Interleukin-33, DVS27-related protein, interleukin-1 family member 11, nuclear factor for high endothelial venules, nuclear factor from high endothelial venules
 
Function
 
Refseq Proteins
 
UniProt
 
PDB
 
Pfam
Pfam Accession Pfam ID
PF15095 IL33
Pathways
 
KEGG
 
Reactome
 

Cytokine-cytokine receptor interaction
Necroptosis
Cytosolic DNA-sensing pathway
Influenza A

 

PIP3 activates AKT signaling
Ub-specific processing proteases
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-33 signaling

Interactions
 
STRING MINT IntAct
ENSP00000327054 Q03252 Q03252
    View interactions
     

Associated Diseases

Disease groupDisease NameReferences
Endocrine System Diseases
PCOS
Neoplasms
Lung Cancer
Reproductive disorders
Endometriosis
Respiratory Tract Diseases
Pneumonia
Asthma
References
 
 
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
ADAMTS1, ADAMTS5, ADAMTS9, IL?17A, IL?23, CRP, TNF-?, IL-1, IL-6, IL-18, ADAMTS16, IL-7 
Insulin resistance, impaired glucose tolerance (IGT), type 2 diabetes mellitus (DM type 2) , metabolic syndrome, malignancy and cardiovascular diseases. 
 
Rotterdam criteria 
Direct 
43 patients undergoing IVF treatment21 diagnosed as PCOS and 22 diagnosed as normal ovulatory women (the control group) 
ADAMTS and IL molecules have a role in the pathogenesis of the PCOS. 

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