PGRMC1: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

PGRMC1

Aliases

Dap1, HPR6.6, IZA, MPR

Entrez Gene ID

10857

Gene Name

Progesterone receptor membrane component 1

Chromosomal Location

Xq24

HGNC ID

HGNC:16090

Summary

This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. [provided by RefSeq, Mar 2010]

RefSeq DNA

NG_016756.1

RefSeq mRNA

NM_006667.5, NM_001282621.1

e!Ensembl

Gene	ENSG00000101856
Transcript	ENST00000217971, ENST00000535419
Protein	ENSP00000217971, ENSP00000442821

Gene Ontology (GO)

Show/Hide all(5 )

GO ID	Ontology	Function	Evidence	Reference
GO:0005783	Cellular component	Endoplasmic reticulum	TAS	25390692
GO:0005887	Cellular component	Integral component of plasma membrane	TAS	25390692
GO:0016020	Cellular component	Membrane	HDA	19946888
GO:0001540	Molecular function	Amyloid-beta binding	TAS	26871627
GO:0005515	Molecular function	Protein binding	IPI	21081644, 27599036

Protein Information

Protein Name

Membrane-associated progesterone receptor component 1, progesterone binding protein

Function

Component of a progesterone-binding protein complex (PubMed:28396637). Binds progesterone (PubMed:25675345). Has many reported cellular functions (heme homeostasis, interaction with CYPs).

Refseq Proteins

NP_006658.1, NP_001269550.1

UniProt

O00264

PDB

4X8Y

Pfam

Pfam Accession	Pfam ID
PF00173	Cyt-b5