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Gene Symbol |
ACACA |
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Aliases |
ACAC, ACACAD, ACC, ACC1, ACCA |
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Entrez Gene ID |
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Gene Name |
Acetyl-CoA carboxylase alpha |
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Chromosomal Location |
17q12 |
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HGNC ID |
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Summary |
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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RefSeq DNA |
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RefSeq mRNA |
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e!Ensembl
| Gene |
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| Transcript |
ENST00000616317, ENST00000612895, ENST00000614428, ENST00000619546, ENST00000617649, ENST00000614482, ENST00000618053, ENST00000615229, ENST00000621960, ENST00000614789, ENST00000617548, ENST00000616352, ENST00000614438, ENST00000612007, ENST00000619487, ENST00000611803, ENST00000613687, ENST00000632453, ENST00000621312, ENST00000631657, ENST00000631953, ENST00000633050, ENST00000632486, ENST00000632723, ENST00000632361, ENST00000615918, ENST00000634140, ENST00000633325 |
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| Protein |
ENSP00000483300, ENSP00000482269, ENSP00000478547, ENSP00000483969, ENSP00000482368, ENSP00000480371, ENSP00000482064, ENSP00000482498, ENSP00000483696, ENSP00000479621, ENSP00000481900, ENSP00000477912, ENSP00000483852, ENSP00000484948, ENSP00000478577, ENSP00000479901, ENSP00000483674, ENSP00000488846, ENSP00000480031, ENSP00000488724, ENSP00000488139, ENSP00000487997, ENSP00000488112, ENSP00000488223, ENSP00000487874, ENSP00000478588, ENSP00000488774, ENSP00000488145
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| Protein Information |
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Protein Name |
Acetyl-CoA carboxylase 1, ACC-alpha, acetyl-Coenzyme A carboxylase alpha |
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Function |
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Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20952656, PubMed:20457939, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20952656, PubMed:20457939, PubMed:29899443). |
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UniProt |
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PDB |
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