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Gene Symbol |
ADAMTS1 |
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Aliases |
C3-C5, METH1 |
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Entrez Gene ID |
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Gene Name |
ADAM metallopeptidase with thrombospondin type 1 motif 1 |
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Chromosomal Location |
21q21.3 |
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HGNC ID |
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Summary |
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]
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e!Ensembl
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Gene Ontology (GO)
| GO ID |
Ontology |
Function |
Evidence |
Reference |
| GO:0007229 |
Biological process |
Integrin-mediated signaling pathway |
TAS |
8995297 |
| GO:0008285 |
Biological process |
Negative regulation of cell proliferation |
TAS |
10438512 |
| GO:1900087 |
Biological process |
Positive regulation of G1/S transition of mitotic cell cycle |
IGI |
28890348 |
| GO:1904707 |
Biological process |
Positive regulation of vascular smooth muscle cell proliferation |
IGI |
28890348 |
| GO:1904754 |
Biological process |
Positive regulation of vascular associated smooth muscle cell migration |
IGI |
28890348 |
| GO:0062023 |
Cellular component |
Collagen-containing extracellular matrix |
HDA |
28327460 |
| GO:0008237 |
Molecular function |
Metallopeptidase activity |
TAS |
10438512 |
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| Protein Information |
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Protein Name |
A disintegrin and metalloproteinase with thrombospondin motifs 1, ADAM-TS 1, ADAM-TS1, ADAMTS-1, METH-1, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1, human metalloproteinase with thrombospondin type 1 motifs |
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Function |
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UniProt |
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PDB |
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Interactions |
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| STRING |
MINT |
IntAct |
| ENSP00000362524 |
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Q9UKU9 |
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View interactions
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Associated Diseases
| Disease group | Disease Name | References |
| Endocrine System Diseases |
| PCOS |
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| Neoplasms |
| Lung Cancer |
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| Breast Cancer |
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| Liver Cancer |
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References |
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| PubMed ID |
Associated gene/s |
Associated condition |
Genetic Mutation |
Diagnostic Criteria |
Association with PCOS |
Ethnicity |
Conclusion |
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Direct
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Women with PCOS (n = 21) and normal ovulatory controls (n = 22) |
Altered levels of ADAMTS-1 and aggrecan may have a partial role in the etiopathogenesis of PCOS, and ADAMTS-1 could be a predictive marker for implantation success in PCOS patients. |
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ADAMTS5, ADAMTS9, IL?17A, IL?23, IL?33,CRP, TNF-?, IL-1, IL-6, IL-18, ADAMTS16, IL-4 |
Insulin resistance, impaired glucose tolerance (IGT), type 2 diabetes mellitus (DM type 2) , metabolic syndrome, malignancy and cardiovascular diseases. |
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Rotterdam criteria |
Direct
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43 patients undergoing IVF treatment—21 diagnosed as PCOS and 22 diagnosed as normal ovulatory women (the control group) |
ADAMTS and IL molecules have a role in the pathogenesis of the PCOS. |
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