ADIPOQ: Polycystic Ovarian Syndrome Database

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ADIPOQ

Gene Information

Gene Ontology (GO)

Protein Information

Associated Diseases

Pathways

References

Gene Information

Gene Symbol

ADIPOQ

Aliases

ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, APM1, GBP28

Entrez Gene ID

9370

Gene Name

Adiponectin, C1Q and collagen domain containing

Chromosomal Location

3q27.3

HGNC ID

HGNC:13633

Summary

This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]

RefSeq DNA

NG_021140.1

RefSeq mRNA

NM_001177800.2, NM_004797.4

e!Ensembl

Gene	ENSG00000181092
Transcript	ENST00000320741, ENST00000444204
Protein	ENSP00000320709, ENSP00000389814

Gene Ontology (GO)

Show/Hide all(58 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001934	Biological process	Positive regulation of protein phosphorylation	IDA	18431508
GO:0006006	Biological process	Glucose metabolic process	ISS	12368907
GO:0006091	Biological process	Generation of precursor metabolites and energy	TAS	10095105
GO:0006635	Biological process	Fatty acid beta-oxidation	ISS	12368907
GO:0009749	Biological process	Response to glucose	ISS	12368907
GO:0009967	Biological process	Positive regulation of signal transduction	ISS	12368907
GO:0010642	Biological process	Negative regulation of platelet-derived growth factor receptor signaling pathway	IDA	12070119
GO:0010739	Biological process	Positive regulation of protein kinase A signaling	IDA	10982546
GO:0010745	Biological process	Negative regulation of macrophage derived foam cell differentiation	IDA	11222466
GO:0010804	Biological process	Negative regulation of tumor necrosis factor-mediated signaling pathway	IDA	10604883
GO:0010875	Biological process	Positive regulation of cholesterol efflux	IDA	18703020
GO:0010906	Biological process	Regulation of glucose metabolic process	IDA	17327472
GO:0030853	Biological process	Negative regulation of granulocyte differentiation	IDA	10961870
GO:0031953	Biological process	Negative regulation of protein autophosphorylation	IDA	12070119
GO:0032270	Biological process	Positive regulation of cellular protein metabolic process	IDA	18703020
GO:0032720	Biological process	Negative regulation of tumor necrosis factor production	IDA	10961870
GO:0032757	Biological process	Positive regulation of interleukin-8 production	IDA	19524870
GO:0033034	Biological process	Positive regulation of myeloid cell apoptotic process	IDA	10961870
GO:0034115	Biological process	Negative regulation of heterotypic cell-cell adhesion	IDA	10604883
GO:0034383	Biological process	Low-density lipoprotein particle clearance	IDA	11222466
GO:0034612	Biological process	Response to tumor necrosis factor	IDA	10604883
GO:0042593	Biological process	Glucose homeostasis	ISS	12368907
GO:0043124	Biological process	Negative regulation of I-kappaB kinase/NF-kappaB signaling	IDA	10982546
GO:0045599	Biological process	Negative regulation of fat cell differentiation	IDA	12021245
GO:0045650	Biological process	Negative regulation of macrophage differentiation	IDA	10961870
GO:0045715	Biological process	Negative regulation of low-density lipoprotein particle receptor biosynthetic process	IDA	11222466
GO:0045721	Biological process	Negative regulation of gluconeogenesis	ISS	12368907
GO:0045776	Biological process	Negative regulation of blood pressure	IDA	17327472
GO:0045892	Biological process	Negative regulation of transcription, DNA-templated	IDA	18431508
GO:0045923	Biological process	Positive regulation of fatty acid metabolic process	ISS	12368907
GO:0046326	Biological process	Positive regulation of glucose import	ISS	12368907
GO:0050728	Biological process	Negative regulation of inflammatory response	NAS	12611609
GO:0050765	Biological process	Negative regulation of phagocytosis	IDA	10961870
GO:0050805	Biological process	Negative regulation of synaptic transmission	IDA	17327472
GO:0070373	Biological process	Negative regulation of ERK1 and ERK2 cascade	IDA	12070119
GO:0071639	Biological process	Positive regulation of monocyte chemotactic protein-1 production	IDA	19524870
GO:0072659	Biological process	Protein localization to plasma membrane	IDA	18431508
GO:0090317	Biological process	Negative regulation of intracellular protein transport	IDA	18431508
GO:0120162	Biological process	Positive regulation of cold-induced thermogenesis	ISS	24531262, 26166748
GO:0120163	Biological process	Negative regulation of cold-induced thermogenesis	ISS	24531262, 26166748
GO:1900121	Biological process	Negative regulation of receptor binding	IDA	12070119
GO:1904706	Biological process	Negative regulation of vascular smooth muscle cell proliferation	IDA	12070119
GO:1904753	Biological process	Negative regulation of vascular associated smooth muscle cell migration	IDA	12070119
GO:2000279	Biological process	Negative regulation of DNA biosynthetic process	IDA	12070119
GO:2000481	Biological process	Positive regulation of cAMP-dependent protein kinase activity	IDA	18431508, 19524870
GO:2000534	Biological process	Positive regulation of renal albumin absorption	IDA	18431508
GO:0005576	Cellular component	Extracellular region	HDA	27068509
GO:0005615	Cellular component	Extracellular space	IDA	10403784, 15585515, 17327472
GO:0009986	Cellular component	Cell surface	IDA	10982546
GO:0062023	Cellular component	Collagen-containing extracellular matrix	HDA	28675934
GO:0005102	Molecular function	Signaling receptor binding	ISS	12368907
GO:0005125	Molecular function	Cytokine activity	NAS	12611609
GO:0005179	Molecular function	Hormone activity	IDA	11222466
GO:0005201	Molecular function	Extracellular matrix structural constituent	RCA	28675934
GO:0005515	Molecular function	Protein binding	IPI	12070119, 25910212
GO:0033691	Molecular function	Sialic acid binding	IDA	19855092
GO:0042802	Molecular function	Identical protein binding	TAS	10961870
GO:0042803	Molecular function	Protein homodimerization activity	IPI	12021245

Protein Information

Protein Name

Adiponectin, 30 kDa adipocyte complement-related protein, adipocyte complement-related 30 kDa protein, adipose most abundant gene transcript 1 protein, adipose specific collagen-like factor, gelatin-binding protein 28

Function

Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW

Refseq Proteins

NP_001171271.1, NP_004788.1

UniProt

Q15848

PDB

4DOU

Pfam

Pfam Accession	Pfam ID
PF00386	C1q
PF01391	Collagen

Pathways
	KEGG	Reactome
	PPAR signaling pathway AMPK signaling pathway Longevity regulating pathway Adipocytokine signaling pathway Type II diabetes mellitus Non-alcoholic fatty liver disease (NAFLD)	AMPK inhibits chREBP transcriptional activation activity Transcriptional regulation of white adipocyte differentiation

Interactions

STRING	MINT	IntAct
ENSP00000335074		Q9UBU3

View interactions

Associated Diseases

Show/Hide all(8 )

Disease group	Disease Name	References
Cardiovascular Diseases
	Myocardial Ischemia	16155579
	Heart Failure	26670611, 19367012
	Myocardial Failure	19367012, 26670611
	Atherosclerosis	18931039
	Coronary Restenosis	12138120
	Hyperemia	12860835
	Hypertensive disease	12860835
Digestive System Diseases
	Liver Diseases	20709802
	Non-alcoholic Fatty Liver Disease	20415685
	Crohn Disease	21829567
	Hepatitis	20709802
	Enteritis	21829567
	Colitis	21829567
Endocrine System Diseases
	Glomerulosclerosis	17942768
	Diabetes Mellitus	12354786, 12114044, 15734870, 12860835
	PCOS	30509295, 20080859
Immune System Diseases
Immune System Diseases	Rheumatoid Arthritis	12833524
Nutritional and Metabolic Diseases
	Metabolic Syndrome X	17618945, 20833989, 16793964, 18162013
	Obesity	14617771, 10092513
	Hypoadiponectinemia	10918532, 12878598
	Adiponectin Deficiency	10918532
	Gluocose Intolerance	20494887, 19263799, 19087913, 18448614
Psychiatric/Brain disorders
Psychiatric/Brain disorders	Obstructive Sleep Apnea	29968150, 31008949, 18198351, 22884135
Renal Disorder
	Kidney Failure	19539174
	Diabetic Nephropathy	17942768
Respiratory Tract Diseases
	Pulmonary Fibrosis	25945502
	Pulmonary Edema	25945502

References

Show/Hide all(7)

PubMed ID	Associated gene/s	Associated condition	Genetic Mutation	Diagnostic Criteria	Association with PCOS	Ethnicity	Conclusion
25537248		PCOS	rs1501299		Direct	224 unrelated Han Chinese PCOS patients and parents	TDT confirms that SNP rs1501299 in the ADIPOQ is significantly associated with the risk of PCOS in the Chinese Han population. The three SNP of the ADIPOQ were not associated with the obesity of PCOS.
24057296	NPPA	PCOS		Rotterdam criteria	Direct	40 PCOS patients, 36 controls	Women with PCOS had lower ANP and adiponectin compared with controls matched for age and BMI. Thus, the mechanisms that affect ANP and adiponectin production and clearance may be altered in PCOS, regardless of adiposity. These hormones may be involved in the metabolic features of PCOS.
23685884		PCOS, Blood Pressure	Haplotype TGTG from SNP 45T/G and 276G/T		Related	80 women with PCOS and 1500 non-hirsute controls	Haplotype TGTG from adiponectin gene variants 45T/G and 276G/T is related to susceptibility to PCOS, and might be associated with increased blood pressure in PCOS.
23276562		PCOS		Rotterdam criteria	Related	118 young Taiwanese women with PCOS	The study demonstrates that adiponectin is an independent biomarker that is positively and evidently related to HDL-C and TGs in women with PCOS
23864804	IGFBP-3, TNF	PCOS, insulin sensitivity		NICHD criteria	Related	40 women with PCOS and 40 age- and body mass index (BMI)-matched regular cycling women (controls)	IGFBP-3 and TNF levels were not associated with insulin sensitivity, but adiponectin levels were related to insulin sensitivity in women with PCOS.
15590747		PCOS	45T>G and 276G>T	NIH-NICHD criteria	Related	100 PCOS, 140 controls	Adiponectin gene polymorphisms at positions +45 and +276 are not associated with PCOS. However, these genomic variants may influence production of adiponectin and the metabolic variables related to insulin resistance/metabolic syndrome in patients with PCOS
24559720		PCOS	rs2241766, rs1501299	Rotterdam criteria	Related	224 unrelated PCOS probands, their biologic parents, and 204 control subjects of Chinese Han population	The results of this study confirms that the SNP rs1501299 in the ADIPOQ is significantly associated with the risk of PCOS in the Chinese Han population

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