ADIPOR1: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

ADIPOR1

Aliases

ACDCR1, CGI-45, CGI45, PAQR1, TESBP1A

Entrez Gene ID

51094

Gene Name

Adiponectin receptor 1

Chromosomal Location

1q32.1

HGNC ID

HGNC:24040

Summary

This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014]

RefSeq DNA

NG_052860.1

RefSeq mRNA

NM_001290629.1, NM_015999.6, NM_001290553.1, NM_001290557.1

e!Ensembl

Gene	ENSG00000159346
Transcript	ENST00000340990, ENST00000417068, ENST00000426229, ENST00000367254
Protein	ENSP00000341785, ENSP00000402178, ENSP00000392946, ENSP00000356223

Gene Ontology (GO)

Show/Hide all(17 )

GO ID	Ontology	Function	Evidence	Reference
GO:0009755	Biological process	Hormone-mediated signaling pathway	IDA	12802337
GO:0010633	Biological process	Negative regulation of epithelial cell migration	IMP	23776679
GO:0010719	Biological process	Negative regulation of epithelial to mesenchymal transition	IMP	23776679
GO:0019395	Biological process	Fatty acid oxidation	IDA	12802337
GO:0033211	Biological process	Adiponectin-activated signaling pathway	IBA	21873635
GO:0033211	Biological process	Adiponectin-activated signaling pathway	IDA	12802337
GO:0046426	Biological process	Negative regulation of JAK-STAT cascade	IMP	23776679
GO:0120162	Biological process	Positive regulation of cold-induced thermogenesis	ISS	24531262
GO:1901223	Biological process	Negative regulation of NIK/NF-kappaB signaling	IMP	23776679
GO:0005886	Cellular component	Plasma membrane	IBA	21873635
GO:0005886	Cellular component	Plasma membrane	IDA	19233263
GO:0016020	Cellular component	Membrane	HDA	19946888
GO:0031226	Cellular component	Intrinsic component of plasma membrane	IDA	12802337
GO:0019901	Molecular function	Protein kinase binding	IPI	19233263
GO:0038023	Molecular function	Signaling receptor activity	IBA	21873635
GO:0055100	Molecular function	Adiponectin binding	IDA	12802337
GO:0097003	Molecular function	Adipokinetic hormone receptor activity	IDA	12802337

Protein Information

Protein Name

Adiponectin receptor protein 1, progestin and adipoQ receptor family member 1, progestin and adipoQ receptor family member I

Function

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:25855295, PubMed:12802337). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).

Refseq Proteins

NP_001277558.1, NP_057083.2, NP_001277482.1, NP_001277486.1

UniProt

Q96A54

PDB

3WXV, 5LXG

Pfam

Pfam Accession	Pfam ID
PF03006	HlyIII