ADIPOR2

Gene Information
 
Gene Symbol
ADIPOR2
 
Aliases
ACDCR2, PAQR2
 
Entrez Gene ID
 
Gene Name
Adiponectin receptor 2
 
Chromosomal Location
12p13.33
 
HGNC ID
 
Summary
The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0009755 Biological process Hormone-mediated signaling pathway ISS 12802337
GO:0019395 Biological process Fatty acid oxidation ISS 12802337
GO:0033211 Biological process Adiponectin-activated signaling pathway IBA 21873635
GO:0033211 Biological process Adiponectin-activated signaling pathway IDA 12802337
GO:0120162 Biological process Positive regulation of cold-induced thermogenesis ISS 24531262
Protein Information
 
Protein Name
Adiponectin receptor protein 2, progestin and adipoQ receptor family member 2, progestin and adipoQ receptor family member II
 
Function
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity).
 
UniProt
 
PDB
 
Pfam
Pfam Accession Pfam ID
PF03006 HlyIII
Pathways
 
KEGG
 
Reactome
 

AMPK signaling pathway
Longevity regulating pathway
Adipocytokine signaling pathway
Non-alcoholic fatty liver disease (NAFLD)

 

AMPK inhibits chREBP transcriptional activation activity

Interactions
 
STRING MINT IntAct
ENSP00000271331
    View interactions
     

Associated Diseases

Disease groupDisease NameReferences
Endocrine System Diseases
PCOS
Reproductive disorders
Subfertility, Female
References
 
 
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
AdipoR1 
 
 
 
Related 
16 PCO, 9 controls 
A significantly lower proportion of theca cells expressed adiponectin receptors 1 and 2 (AdipoR1, AdipoR2) in polycystic ovaries than in normal ovaries. These results provide evidence for a direct link between fat cell metabolism and ovarian steroidogenesis, suggesting that disruption of adiponectin and/or its receptors plays a key role in pathogenesis of hyperandrogenism in PCOS 

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