ADIPOR2: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

ADIPOR2

Aliases

ACDCR2, PAQR2

Entrez Gene ID

79602

Gene Name

Adiponectin receptor 2

Chromosomal Location

12p13.33

HGNC ID

HGNC:24041

Summary

The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]

e!Ensembl

Gene	ENSG00000006831, ENSG00000285070
Transcript	ENST00000357103, ENST00000645126
Protein	ENSP00000349616, ENSP00000495699

Gene Ontology (GO)

Show/Hide all(10 )

GO ID	Ontology	Function	Evidence	Reference
GO:0009755	Biological process	Hormone-mediated signaling pathway	ISS	12802337
GO:0019395	Biological process	Fatty acid oxidation	ISS	12802337
GO:0033211	Biological process	Adiponectin-activated signaling pathway	IBA	21873635
GO:0033211	Biological process	Adiponectin-activated signaling pathway	IDA	12802337
GO:0120162	Biological process	Positive regulation of cold-induced thermogenesis	ISS	24531262
GO:0005886	Cellular component	Plasma membrane	IBA	21873635
GO:0031226	Cellular component	Intrinsic component of plasma membrane	IDA	12802337
GO:0038023	Molecular function	Signaling receptor activity	IBA	21873635
GO:0055100	Molecular function	Adiponectin binding	IDA	12802337
GO:0097003	Molecular function	Adipokinetic hormone receptor activity	IDA	12802337

Protein Information

Protein Name

Adiponectin receptor protein 2, progestin and adipoQ receptor family member 2, progestin and adipoQ receptor family member II

Function

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity).

UniProt

Q86V24

PDB

3WXW, 5LWY, 5LX9, 5LXA

Pfam

Pfam Accession	Pfam ID
PF03006	HlyIII