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Gene Symbol |
ADM |
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Aliases |
AM, PAMP |
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Entrez Gene ID |
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Gene Name |
Adrenomedullin |
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Chromosomal Location |
11p15.4 |
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HGNC ID |
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Summary |
The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]
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e!Ensembl
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| Protein Information |
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Protein Name |
ADM, preproadrenomedullin, proadrenomedullin N-20 terminal peptide |
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Function |
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AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels |
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UniProt |
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PDB |
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Pfam |
| Pfam Accession |
Pfam ID |
| PF00214 |
Calc_CGRP_IAPP |
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Interactions |
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| STRING |
MINT |
IntAct |
| ENSP00000363822 |
P10275 |
P10275 |
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View interactions
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Associated Diseases
| Disease group | Disease Name | References |
| Digestive System Diseases |
| Gastric ulcer |
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| Endocrine System Diseases |
| PCOS |
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| Psychiatric/Brain disorders |
| Autistic Disorder |
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| Schizophrenia |
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| Bipolar Disorder |
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| Renal Disorder |
| Glomerulonephritis |
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| Nephritis |
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References |
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| Sahin I, Celik O, Celik N, Keskin L, Dogru A, Dogru I, Yurekli M, Yologlu S |
| Endocrinology and Metabolism, Inonu University, Malatya, Turkey. isahin@inonu.edu.tr |
| J Endocrinol Invest. 2012 Jun;35(6):553-6. doi: 10.3275/7872. Epub 2011 Jul 25. |
Abstract
The aim of the study was to investigate adrenomedullin (ADM) levels and its relation with insulin resistance in women with polycystic ovary syndrome (PCOS). Twenty-nine women with PCOS and 29 age- and body mass index (BMI)- matched control subjects were included in the study. PCOS was defined according to criteria by the Rotterdam European Society of Human Reproduction and Embryology/American Society for Reproductive Medicine (ESHRE/ASRM)-sponsored PCOS consensus workshop group. A full clinical and biochemical examination including basal hormones and metabolic profile was performed. Insulin resistance was calculated by using the homeostasis model assessment of insulin resistance index (HOMA-IR). Plasma ADM levels were measured by high performance liquid chromatographic (HPLC) method. Plasma ADM, fasting insulin levels and HOMA-IR were significantly higher in patients with PCOS than the control group. ADM levels were positively correlated with insulin levels and HOMA-IR index. The best cut-off value of ADM levels to identify the presence of insulin resistance (HOMA-IR>/=2.7) was 30.44 ng/ml. Calculated odds ratio of insulin resistance by using logistic regression analysis, as predicted by ADM, was 0.15 (95% confidence interval, 0.037-0.628; p=0.009). In multiple regression analysis, ADM level was an independent predictor of HOMA-IR index. Our finding indicated that ADM levels increased in women with PCOS in accordance with HOMA-IR. ADM could be a significant independent determinant of insulin resistance in women with PCOS. |
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National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
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