ADRB2: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

ADRB2

Aliases

ADRB2R, ADRBR, B2AR, BAR, BETA2AR

Entrez Gene ID

154

Gene Name

Adrenoceptor beta 2

Chromosomal Location

5q32

HGNC ID

HGNC:286

Summary

This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This receptor is also a transcription regulator of the alpha-synuclein gene, and together, both genes are believed to be associated with risk of Parkinson's Disease. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity, type 2 diabetes and cardiovascular disease. [provided by RefSeq, Oct 2019]

RefSeq DNA

NG_016421.1

RefSeq mRNA

NM_000024.5

e!Ensembl

Gene	ENSG00000169252
Transcript	ENST00000305988
Protein	ENSP00000305372

Gene Ontology (GO)

Show/Hide all(40 )

GO ID	Ontology	Function	Evidence	Reference
GO:0002025	Biological process	Norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IBA	21873635
GO:0002032	Biological process	Desensitization of G protein-coupled receptor signaling pathway by arrestin	IDA	15123695
GO:0006898	Biological process	Receptor-mediated endocytosis	IDA	15123695
GO:0007166	Biological process	Cell surface receptor signaling pathway	TAS	1371121
GO:0007171	Biological process	Activation of transmembrane receptor protein tyrosine kinase activity	TAS	10734107
GO:0007188	Biological process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007190	Biological process	Activation of adenylate cyclase activity	IDA	15123695
GO:0008333	Biological process	Endosome to lysosome transport	TAS	9507004
GO:0010739	Biological process	Positive regulation of protein kinase A signaling	IGI	20395454
GO:0031398	Biological process	Positive regulation of protein ubiquitination	IMP	19372219
GO:0043410	Biological process	Positive regulation of MAPK cascade	IDA	15123695
GO:0045986	Biological process	Negative regulation of smooth muscle contraction	IBA	21873635
GO:0071875	Biological process	Adrenergic receptor signaling pathway	IDA	19710023
GO:0071880	Biological process	Adenylate cyclase-activating adrenergic receptor signaling pathway	IBA	21873635
GO:0071902	Biological process	Positive regulation of protein serine/threonine kinase activity	IGI	20395454
GO:0120162	Biological process	Positive regulation of cold-induced thermogenesis	ISS	12387862
GO:1901098	Biological process	Positive regulation of autophagosome maturation	IDA	23708524
GO:1904504	Biological process	Positive regulation of lipophagy	IDA	23708524
GO:1904646	Biological process	Cellular response to amyloid-beta	IGI	20395454
GO:1990911	Biological process	Response to psychosocial stress	TAS	20395454
GO:2000481	Biological process	Positive regulation of cAMP-dependent protein kinase activity	TAS	20395454
GO:2000969	Biological process	Positive regulation of AMPA receptor activity	IGI	20395454
GO:0005764	Cellular component	Lysosome	TAS	9507004
GO:0005768	Cellular component	Endosome	TAS	10734107
GO:0005886	Cellular component	Plasma membrane	IDA	9235896
GO:0005887	Cellular component	Integral component of plasma membrane	IBA	21873635
GO:0005887	Cellular component	Integral component of plasma membrane	IDA	12297500, 19710023
GO:0016020	Cellular component	Membrane	NAS	20395454
GO:0043235	Cellular component	Receptor complex	IDA	15123695, 23382219
GO:0001540	Molecular function	Amyloid-beta binding	IDA	20395454
GO:0004935	Molecular function	Adrenergic receptor activity	IBA	21873635
GO:0004941	Molecular function	Beta2-adrenergic receptor activity	IBA	21873635
GO:0004941	Molecular function	Beta2-adrenergic receptor activity	IDA	15123695, 19710023
GO:0004941	Molecular function	Beta2-adrenergic receptor activity	NAS	20395454
GO:0005515	Molecular function	Protein binding	IPI	9560162, 9671706, 15123695, 17148612, 17170700, 19424180, 19584355, 20353789, 20733053, 23208550, 23236378, 24405750, 28298427
GO:0015459	Molecular function	Potassium channel regulator activity	IDA	12297500
GO:0042803	Molecular function	Protein homodimerization activity	IDA	15123695
GO:0044877	Molecular function	Protein-containing complex binding	IPI	20395454
GO:0051379	Molecular function	Epinephrine binding	IBA	21873635
GO:0051380	Molecular function	Norepinephrine binding	IDA	15123695

Protein Information

Protein Name

Beta-2 adrenergic receptor, adrenergic, beta-2-, receptor, surface, adrenoceptor beta 2 surface, beta-2 adrenoceptor, beta-2 adrenoreceptor, catecholamine receptor

Function

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.

Refseq Proteins

NP_000015.1

UniProt

P07550

PDB

1GQ4, 2R4R, 2R4S, 2RH1, 3D4S, 3KJ6, 3NY8, 3NY9, 3NYA, 3P0G, 3PDS, 3SN6, 4GBR, 4LDE, 4LDL, 4LDO, 4QKX, 5D5A, 5D5B, 5D6L, 5JQH, 5X7D, 6MXT