ADRB3: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

ADRB3

Aliases

BETA3AR

Entrez Gene ID

155

Gene Name

Adrenoceptor beta 3

Chromosomal Location

8p11.23

HGNC ID

HGNC:288

Summary

The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Obesity and bodyweight-related disorders are correlated with certain polymorphisms in three subtypes of beta-adrenoceptor, among them, the ADRB3 gene.[provided by RefSeq, Oct 2019]

RefSeq DNA

NG_011936.1

RefSeq mRNA

NM_000025.3

e!Ensembl

Gene	ENSG00000188778
Transcript	ENST00000345060
Protein	ENSP00000343782

Gene Ontology (GO)

Show/Hide all(23 )

GO ID	Ontology	Function	Evidence	Reference
GO:0002025	Biological process	Norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IBA	21873635
GO:0002032	Biological process	Desensitization of G protein-coupled receptor signaling pathway by arrestin	IDA	15123695
GO:0005975	Biological process	Carbohydrate metabolic process	TAS	2570461
GO:0006091	Biological process	Generation of precursor metabolites and energy	TAS	2570461
GO:0006112	Biological process	Energy reserve metabolic process	TAS	1718744
GO:0006898	Biological process	Receptor-mediated endocytosis	IDA	15123695
GO:0007187	Biological process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	2570461
GO:0007188	Biological process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007190	Biological process	Activation of adenylate cyclase activity	IDA	15123695
GO:0043410	Biological process	Positive regulation of MAPK cascade	IDA	15123695
GO:0071880	Biological process	Adenylate cyclase-activating adrenergic receptor signaling pathway	IBA	21873635
GO:0120162	Biological process	Positive regulation of cold-induced thermogenesis	ISS	7493988, 12387862
GO:0005887	Cellular component	Integral component of plasma membrane	IBA	21873635
GO:0043235	Cellular component	Receptor complex	IDA	15123695
GO:0004935	Molecular function	Adrenergic receptor activity	IBA	21873635
GO:0004939	Molecular function	Beta-adrenergic receptor activity	IDA	15123695
GO:0005515	Molecular function	Protein binding	IPI	15123695
GO:0015052	Molecular function	Beta3-adrenergic receptor activity	IBA	21873635
GO:0015052	Molecular function	Beta3-adrenergic receptor activity	IMP	9892244
GO:0042803	Molecular function	Protein homodimerization activity	IDA	15123695
GO:0051379	Molecular function	Epinephrine binding	IBA	21873635
GO:0051380	Molecular function	Norepinephrine binding	IBA	21873635
GO:0051380	Molecular function	Norepinephrine binding	IDA	15123695

Protein Information

Protein Name

Beta-3 adrenergic receptor, adrenergic, beta-3-, receptor, beta-3 adrenoceptor, beta-3 adrenoreceptor

Function

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis

Refseq Proteins

NP_000016.1

UniProt

P13945

PDB

2CDW

Pfam

Pfam Accession	Pfam ID
PF00001	7tm_1