AGER: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

AGER

Aliases

RAGE, SCARJ1

Entrez Gene ID

177

Gene Name

Advanced glycosylation end-product specific receptor

Chromosomal Location

6p21.32

HGNC ID

HGNC:320

Summary

The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]

RefSeq DNA

NG_029868.1

RefSeq mRNA

NM_001136.4, NR_038190.2, NM_001136.5, NM_172197.3, NM_001206929.1, NM_001206932.2, NM_001206934.1, NM_001206936.2, NM_001206940.2, NM_001206954.2, NM_001206966.2

e!Ensembl

Gene	ENSG00000204305, ENSG00000206320, ENSG00000229058, ENSG00000231268, ENSG00000230514, ENSG00000234729, ENSG00000237405
Transcript	ENST00000375067, ENST00000375055, ENST00000375076, ENST00000450110, ENST00000375056, ENST00000438221, ENST00000375069, ENST00000538695, ENST00000375065, ENST00000620802, ENST00000375070, ENST00000383279, ENST00000383275, ENST00000451115, ENST00000415973, ENST00000453119, ENST00000550854, ENST00000549168, ENST00000547328, ENST00000551254, ENST00000548034, ENST00000549776, ENST00000412470, ENST00000449037, ENST00000456918, ENST00000444630, ENST00000424476, ENST00000549758, ENST00000550959, ENST00000547155, ENST00000553014, ENST00000552517, ENST00000547651, ENST00000424145, ENST00000426320, ENST00000427822, ENST00000454284, ENST00000418313, ENST00000550885, ENST00000549839, ENST00000551244, ENST00000548935, ENST00000547213, ENST00000551378, ENST00000448768, ENST00000452945, ENST00000426138, ENST00000436653, ENST00000412794, ENST00000548009, ENST00000550441, ENST00000552209, ENST00000549227, ENST00000552891, ENST00000546535, ENST00000441180, ENST00000453588, ENST00000436456, ENST00000455471, ENST00000434502, ENST00000552621, ENST00000547770, ENST00000550562, ENST00000552991, ENST00000548959, ENST00000548464, ENST00000441804, ENST00000432831, ENST00000447921, ENST00000416532, ENST00000441753, ENST00000551684, ENST00000549626, ENST00000551677, ENST00000550196, ENST00000551381, ENST00000551827
Protein	ENSP00000364208, ENSP00000364195, ENSP00000364217, ENSP00000398466, ENSP00000364196, ENSP00000387887, ENSP00000364210, ENSP00000445389, ENSP00000364206, ENSP00000484081, ENSP00000364211, ENSP00000372766, ENSP00000372762, ENSP00000401068, ENSP00000395578, ENSP00000411203, ENSP00000450205, ENSP00000449368, ENSP00000448579, ENSP00000449226, ENSP00000449037, ENSP00000449506, ENSP00000387853, ENSP00000400667, ENSP00000409457, ENSP00000401896, ENSP00000394516, ENSP00000447301, ENSP00000449931, ENSP00000448287, ENSP00000446582, ENSP00000446495, ENSP00000449708, ENSP00000391970, ENSP00000407467, ENSP00000416042, ENSP00000415780, ENSP00000411652, ENSP00000449091, ENSP00000448486, ENSP00000446682, ENSP00000448525, ENSP00000446692, ENSP00000449040, ENSP00000397777, ENSP00000403322, ENSP00000415144, ENSP00000388041, ENSP00000397350, ENSP00000449997, ENSP00000446533, ENSP00000448142, ENSP00000449731, ENSP00000446660, ENSP00000449754, ENSP00000388462, ENSP00000399686, ENSP00000397227, ENSP00000391024, ENSP00000399134, ENSP00000447531, ENSP00000448234, ENSP00000446835, ENSP00000449143, ENSP00000447095, ENSP00000450134, ENSP00000391743, ENSP00000413391, ENSP00000395812, ENSP00000412576, ENSP00000410918, ENSP00000448028, ENSP00000449769, ENSP00000449676, ENSP00000449100, ENSP00000448979, ENSP00000449042

Gene Ontology (GO)

Show/Hide all(55 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001914	Biological process	Regulation of T cell mediated cytotoxicity	IDA	22473704
GO:0001934	Biological process	Positive regulation of protein phosphorylation	IGI	15457210
GO:0007166	Biological process	Cell surface receptor signaling pathway	TAS	10835680
GO:0007611	Biological process	Learning or memory	IGI	15457210
GO:0009611	Biological process	Response to wounding	TAS	10399917
GO:0010255	Biological process	Glucose mediated signaling pathway	IDA	25689357
GO:0031175	Biological process	Neuron projection development	IGI	10391939
GO:0032693	Biological process	Negative regulation of interleukin-10 production	IDA	22473704
GO:0032735	Biological process	Positive regulation of interleukin-12 production	IMP	15944249
GO:0034116	Biological process	Positive regulation of heterotypic cell-cell adhesion	IGI	11078691
GO:0042104	Biological process	Positive regulation of activated T cell proliferation	IMP	15944249
GO:0042535	Biological process	Positive regulation of tumor necrosis factor biosynthetic process	ISS	22406537
GO:0045056	Biological process	Transcytosis	ISS	12808450, 22406537
GO:0045080	Biological process	Positive regulation of chemokine biosynthetic process	ISS	22406537
GO:0045410	Biological process	Positive regulation of interleukin-6 biosynthetic process	ISS	22406537
GO:0046330	Biological process	Positive regulation of JNK cascade	IGI	20739563
GO:0048167	Biological process	Regulation of synaptic plasticity	TAS	18367618, 19221410, 20739563
GO:0050725	Biological process	Positive regulation of interleukin-1 beta biosynthetic process	ISS	22406537
GO:0051092	Biological process	Positive regulation of NF-kappaB transcription factor activity	IDA	10391939
GO:0051092	Biological process	Positive regulation of NF-kappaB transcription factor activity	IGI	15457210
GO:0061890	Biological process	Positive regulation of astrocyte activation	IGI	15457210
GO:0070374	Biological process	Positive regulation of ERK1 and ERK2 cascade	IGI	15457210
GO:0090647	Biological process	Modulation of age-related behavioral decline	IGI	15457210
GO:0150003	Biological process	Regulation of spontaneous synaptic transmission	IGI	15457210
GO:1900272	Biological process	Negative regulation of long-term synaptic potentiation	IGI	15457210
GO:1900453	Biological process	Negative regulation of long-term synaptic depression	IGI	20739563
GO:1900745	Biological process	Positive regulation of p38MAPK cascade	IGI	20739563
GO:1901222	Biological process	Regulation of NIK/NF-kappaB signaling	NAS	15457210
GO:1901224	Biological process	Positive regulation of NIK/NF-kappaB signaling	IGI	15457210
GO:1902961	Biological process	Positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	IGI	22406537
GO:1903523	Biological process	Negative regulation of blood circulation	ISS	12808450
GO:1903980	Biological process	Positive regulation of microglial cell activation	IGI	15457210
GO:1903980	Biological process	Positive regulation of microglial cell activation	ISS	22406537
GO:1903980	Biological process	Positive regulation of microglial cell activation	TAS	26871627
GO:1904472	Biological process	Positive regulation of endothelin secretion	ISS	12808450
GO:1904645	Biological process	Response to amyloid-beta	TAS	18367618, 20739563
GO:2000439	Biological process	Positive regulation of monocyte extravasation	IMP	11078691
GO:2000514	Biological process	Regulation of CD4-positive, alpha-beta T cell activation	IDA	22473704
GO:2001200	Biological process	Positive regulation of dendritic cell differentiation	IMP	15944249
GO:0005887	Cellular component	Integral component of plasma membrane	NAS	15457210
GO:0009986	Cellular component	Cell surface	NAS	15457210
GO:0016324	Cellular component	Apical plasma membrane	IDA	26005850
GO:0098794	Cellular component	Postsynapse	TAS	26224839
GO:0001540	Molecular function	Amyloid-beta binding	IDA	29518356
GO:0001540	Molecular function	Amyloid-beta binding	IPI	22406537
GO:0001540	Molecular function	Amyloid-beta binding	NAS	18367618
GO:0001540	Molecular function	Amyloid-beta binding	TAS	15457210, 26871627
GO:0004888	Molecular function	Transmembrane signaling receptor activity	TAS	1378843
GO:0005044	Molecular function	Scavenger receptor activity	TAS	11240025
GO:0005515	Molecular function	Protein binding	IPI	16061848, 16716307, 16954185, 17474147, 17660747, 17726019, 18922799, 19386136, 19944695, 21706016, 21829704, 24474694, 25910212
GO:0038023	Molecular function	Signaling receptor activity	IMP	15457210
GO:0042802	Molecular function	Identical protein binding	IPI	24119142
GO:0044548	Molecular function	S100 protein binding	IPI	15033494
GO:0044877	Molecular function	Protein-containing complex binding	IPI	29518356
GO:0050785	Molecular function	Advanced glycation end-product receptor activity	NAS	15457210

Protein Information

Protein Name

Advanced glycosylation end product-specific receptor, RAGE isoform NtRAGE-delta, RAGE isoform sRAGE-delta, receptor for advanced glycation end-products variant 20

Function

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.

Refseq Proteins

NP_001127.1, , NP_751947.1, NP_001193858.1, NP_001193861.1, NP_001193863.1, NP_001193865.1, NP_001193869.1, NP_001193883.1, NP_001193895.1

UniProt

Q15109

PDB

1PWI, 2BJP, 2E5E, 2ENS, 2L7U, 2LE9, 2LMB, 2M1K, 2MJW, 2MOV, 3CJJ, 3O3U, 4LP4, 4LP5, 4OF5, 4OFV, 4OI7, 4OI8, 4P2Y, 4XYN, 4YBH, 5D7F