Gene Information
Gene Symbol
Entrez Gene ID
Gene Name
Advanced glycosylation end-product specific receptor
Chromosomal Location
The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]
RefSeq DNA
RefSeq mRNA
ENST00000375067, ENST00000375055, ENST00000375076, ENST00000450110, ENST00000375056, ENST00000438221, ENST00000375069, ENST00000538695, ENST00000375065, ENST00000620802, ENST00000375070, ENST00000383279, ENST00000383275, ENST00000451115, ENST00000415973, ENST00000453119, ENST00000550854, ENST00000549168, ENST00000547328, ENST00000551254, ENST00000548034, ENST00000549776, ENST00000412470, ENST00000449037, ENST00000456918, ENST00000444630, ENST00000424476, ENST00000549758, ENST00000550959, ENST00000547155, ENST00000553014, ENST00000552517, ENST00000547651, ENST00000424145, ENST00000426320, ENST00000427822, ENST00000454284, ENST00000418313, ENST00000550885, ENST00000549839, ENST00000551244, ENST00000548935, ENST00000547213, ENST00000551378, ENST00000448768, ENST00000452945, ENST00000426138, ENST00000436653, ENST00000412794, ENST00000548009, ENST00000550441, ENST00000552209, ENST00000549227, ENST00000552891, ENST00000546535, ENST00000441180, ENST00000453588, ENST00000436456, ENST00000455471, ENST00000434502, ENST00000552621, ENST00000547770, ENST00000550562, ENST00000552991, ENST00000548959, ENST00000548464, ENST00000441804, ENST00000432831, ENST00000447921, ENST00000416532, ENST00000441753, ENST00000551684, ENST00000549626, ENST00000551677, ENST00000550196, ENST00000551381, ENST00000551827
ENSP00000364208, ENSP00000364195, ENSP00000364217, ENSP00000398466, ENSP00000364196, ENSP00000387887, ENSP00000364210, ENSP00000445389, ENSP00000364206, ENSP00000484081, ENSP00000364211, ENSP00000372766, ENSP00000372762, ENSP00000401068, ENSP00000395578, ENSP00000411203, ENSP00000450205, ENSP00000449368, ENSP00000448579, ENSP00000449226, ENSP00000449037, ENSP00000449506, ENSP00000387853, ENSP00000400667, ENSP00000409457, ENSP00000401896, ENSP00000394516, ENSP00000447301, ENSP00000449931, ENSP00000448287, ENSP00000446582, ENSP00000446495, ENSP00000449708, ENSP00000391970, ENSP00000407467, ENSP00000416042, ENSP00000415780, ENSP00000411652, ENSP00000449091, ENSP00000448486, ENSP00000446682, ENSP00000448525, ENSP00000446692, ENSP00000449040, ENSP00000397777, ENSP00000403322, ENSP00000415144, ENSP00000388041, ENSP00000397350, ENSP00000449997, ENSP00000446533, ENSP00000448142, ENSP00000449731, ENSP00000446660, ENSP00000449754, ENSP00000388462, ENSP00000399686, ENSP00000397227, ENSP00000391024, ENSP00000399134, ENSP00000447531, ENSP00000448234, ENSP00000446835, ENSP00000449143, ENSP00000447095, ENSP00000450134, ENSP00000391743, ENSP00000413391, ENSP00000395812, ENSP00000412576, ENSP00000410918, ENSP00000448028, ENSP00000449769, ENSP00000449676, ENSP00000449100, ENSP00000448979, ENSP00000449042

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0001914 Biological process Regulation of T cell mediated cytotoxicity IDA 22473704
GO:0001934 Biological process Positive regulation of protein phosphorylation IGI 15457210
GO:0007166 Biological process Cell surface receptor signaling pathway TAS 10835680
GO:0007611 Biological process Learning or memory IGI 15457210
GO:0009611 Biological process Response to wounding TAS 10399917
Protein Information
Protein Name
Advanced glycosylation end product-specific receptor, RAGE isoform NtRAGE-delta, RAGE isoform sRAGE-delta, receptor for advanced glycation end-products variant 20
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.
Refseq Proteins

AGE-RAGE signaling pathway in diabetic complications


TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Advanced glycosylation endproduct receptor signaling
TRAF6 mediated NF-kB activation

ENSP00000365435 P20333 P20333
    View interactions

Associated Diseases

Disease groupDisease NameReferences
Cardiovascular Diseases
Diabetic Cardiomyopathies
Digestive System Diseases
Pancreatic Diseases
Endocrine System Diseases
Diabetes Mellitus
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
6 PCOS and 6 controls 
AGE and RAGE was observed in the granulosa cell layer of PCOS ovaries 
29 PCOS and 22 control 
PCOS women without overt hyperglycaemia have increased AGE levels and elevated RAGE expression when compared with controls 

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