Gene Symbol

AGT

Aliases

ANHU, SERPINA8, hFLT1

Entrez Gene ID

183

Gene Name

Angiotensinogen

Chromosomal Location

1q42.2

HGNC ID

HGNC:333

Summary

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure, body fluid and electrolyte homeostasis, and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Nov 2019]

Function

Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.; [Angiotensin-2]: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.; [Angiotensin-3]: stimulates aldosterone release.; [Angiotensin 1-7]: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets

P01019

PDB

4APH, 4FYS, 1N9U, 1N9V, 2JP8, 2WXW, 2X0B, 3CK0, 3WOO, 3WOR, 4AA1, 5E2Q, 5M3X, 5M3Y, 5XJM, 6I3F, 6I3I

STRING	MINT	IntAct
ENSP00000264657	P40763	P40763

PMID: 16275260

The M235T polymorphism of the angiotensinogen gene in women with polycystic ovary syndrome. Zulian Elisa, Sartorato Paola, Schiavi Francesca, Moghetti Paolo, Castello Roberto, Mantero Franco, Opocher Giuseppe, Scaroni Carla Division of Endocrinology, Department of Medical and Surgical Sciences, University of Padova, Padova, Italy. Fertil Steril. 2005 Nov;84(5):1520-1. doi: 10.1016/j.fertnstert.2005.05.043. Abstract To explore the relationship between variation in AGT M235T gene and the development of the polycystic ovary syndrome (PCOS) and its sequelae, in the present study we evaluated AGT polymorphism M235T in women with PCOS and in a control group. Moreover, to detect any relationship between AGT M235T variation and intermediate and quantitative traits relevant to the pathogenesis of cardiovascular disease and PCOS, we looked for genotype-dependent differences within the subjects with PCOS.