AKR1C3: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

AKR1C3

Aliases

DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS

Entrez Gene ID

8644

Gene Name

Aldo-keto reductase family 1 member C3

Chromosomal Location

10p15.1

HGNC ID

HGNC:386

Summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

RefSeq DNA

NG_047094.1

RefSeq mRNA

NM_001253908.1, NM_003739.6, NM_001253909.2

e!Ensembl

Gene	ENSG00000196139
Transcript	ENST00000602997, ENST00000439082, ENST00000605149, ENST00000380554
Protein	ENSP00000474188, ENSP00000401327, ENSP00000474882, ENSP00000369927

Gene Ontology (GO)

Show/Hide all(62 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006693	Biological process	Prostaglandin metabolic process	IBA	21873635
GO:0006693	Biological process	Prostaglandin metabolic process	IEP	20036328
GO:0006693	Biological process	Prostaglandin metabolic process	TAS	9792917
GO:0007186	Biological process	G protein-coupled receptor signaling pathway	IDA	18508192
GO:0007584	Biological process	Response to nutrient	IEP	19007764
GO:0008202	Biological process	Steroid metabolic process	IBA	21873635
GO:0008202	Biological process	Steroid metabolic process	IEP	20036328
GO:0008284	Biological process	Positive regulation of cell proliferation	IDA	18508192, 20036328
GO:0008284	Biological process	Positive regulation of cell proliferation	IMP	21851338
GO:0008584	Biological process	Male gonad development	IEP	19942269
GO:0009267	Biological process	Cellular response to starvation	IEP	18641923
GO:0010942	Biological process	Positive regulation of cell death	IDA	21787718
GO:0016488	Biological process	Farnesol catabolic process	IDA	21187079
GO:0030216	Biological process	Keratinocyte differentiation	IEP	22170488
GO:0034614	Biological process	Cellular response to reactive oxygen species	IDA	21787718
GO:0042448	Biological process	Progesterone metabolic process	IBA	21873635
GO:0042448	Biological process	Progesterone metabolic process	IDA	21232532
GO:0042574	Biological process	Retinal metabolic process	IDA	21851338
GO:0043170	Biological process	Macromolecule metabolic process	IEP	18641923
GO:0044597	Biological process	Daunorubicin metabolic process	IBA	21873635
GO:0044597	Biological process	Daunorubicin metabolic process	IMP	20837989
GO:0044598	Biological process	Doxorubicin metabolic process	IBA	21873635
GO:0044598	Biological process	Doxorubicin metabolic process	IMP	20837989
GO:0048385	Biological process	Regulation of retinoic acid receptor signaling pathway	IDA	21851338
GO:0051897	Biological process	Positive regulation of protein kinase B signaling	IDA	18508192
GO:0055114	Biological process	Oxidation-reduction process	IDA	16983398, 19442656, 21232532
GO:0055114	Biological process	Oxidation-reduction process	TAS	9792917
GO:0061370	Biological process	Testosterone biosynthetic process	IMP	16983398
GO:0070293	Biological process	Renal absorption	NAS	16157291
GO:0071276	Biological process	Cellular response to cadmium ion	IDA	21787718
GO:0071277	Biological process	Cellular response to calcium ion	IDA	22170488
GO:0071379	Biological process	Cellular response to prostaglandin stimulus	IDA	22170488
GO:0071384	Biological process	Cellular response to corticosteroid stimulus	IDA	19336506
GO:0071395	Biological process	Cellular response to jasmonic acid stimulus	IDA	19487289
GO:0071799	Biological process	Cellular response to prostaglandin D stimulus	IDA	18508192
GO:1900053	Biological process	Negative regulation of retinoic acid biosynthetic process	IDA	21851338
GO:2000224	Biological process	Regulation of testosterone biosynthetic process	IMP	19336506
GO:2000353	Biological process	Positive regulation of endothelial cell apoptotic process	IDA	19442656
GO:2000379	Biological process	Positive regulation of reactive oxygen species metabolic process	IDA	19442656
GO:0005634	Cellular component	Nucleus	IDA	18574251
GO:0005737	Cellular component	Cytoplasm	IDA	18574251, 19336506, 19942269, 22170488
GO:0005829	Cellular component	Cytosol	IBA	21873635
GO:0070062	Cellular component	Extracellular exosome	HDA	23533145
GO:0001758	Molecular function	Retinal dehydrogenase activity	IDA	21851338
GO:0004032	Molecular function	Alditol:NADP+ 1-oxidoreductase activity	IBA	21873635
GO:0004032	Molecular function	Alditol:NADP+ 1-oxidoreductase activity	IDA	21232532
GO:0004033	Molecular function	Aldo-keto reductase (NADP) activity	TAS	9792917
GO:0004745	Molecular function	Retinol dehydrogenase activity	IDA	21851338
GO:0008106	Molecular function	Alcohol dehydrogenase (NADP+) activity	IBA	21873635
GO:0016229	Molecular function	Steroid dehydrogenase activity	IBA	21873635
GO:0016491	Molecular function	Oxidoreductase activity	IBA	21873635
GO:0016655	Molecular function	Oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IDA	19442656, 20837989
GO:0018636	Molecular function	Phenanthrene 9,10-monooxygenase activity	IDA	21851338
GO:0035410	Molecular function	Dihydrotestosterone 17-beta-dehydrogenase activity	IDA	16983398
GO:0045550	Molecular function	Geranylgeranyl reductase activity	IDA	21187079
GO:0045703	Molecular function	Ketoreductase activity	IDA	19487289
GO:0047020	Molecular function	15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	IDA	22170488
GO:0047023	Molecular function	Androsterone dehydrogenase activity	IBA	21873635
GO:0047023	Molecular function	Androsterone dehydrogenase activity	IDA	16983398
GO:0047086	Molecular function	Ketosteroid monooxygenase activity	IBA	21873635
GO:0047086	Molecular function	Ketosteroid monooxygenase activity	IDA	21232532
GO:0047787	Molecular function	Delta4-3-oxosteroid 5beta-reductase activity	IDA	16983398

Protein Information

Protein Name

Aldo-keto reductase family 1 member C3, 3-alpha hydroxysteroid dehydrogenase, type II, 3-alpha-HSD type II, brain, chlordecone reductase homolog HAKRb, dihydrodiol dehydrogenase 3, dihydrodiol dehydrogenase X, indanol dehydrogenase, prostaglandin F synthase, testosterone 17-beta-dehydrogenase 5, trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, type IIb 3-alpha hydroxysteroid dehydrogenase

Function

Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone

Refseq Proteins

NP_001240837.1, NP_003730.4, NP_001240838.1

UniProt

P42330

PDB

1RY0, 1RY8, 1S1P, 1S1R, 1S2A, 1S2C, 1XF0, 1ZQ5, 2F38, 2FGB, 3R43, 3R58, 3R6I, 3R7M, 3R8G, 3R8H, 3R94, 3UFY, 3UG8, 3UGR, 3UWE, 4DBS, 4DBU, 4DBW, 4DZ5, 4FA3, 4FAL, 4FAM, 4H7C, 4HMN, 4WDT, 4WDU, 4WDW, 4WDX, 4WRH, 4XVD, 4XVE, 4YVV, 4YVX, 4ZFC, 5HNT, 5HNU, 5JM5, 6F2U, 6F78