AKT1: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

AKT1

Aliases

AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA

Entrez Gene ID

207

Gene Name

AKT serine/threonine kinase 1

Chromosomal Location

14q32.33

HGNC ID

HGNC:391

Summary

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]

RefSeq DNA

NG_012188.1

RefSeq mRNA

NM_001014431.2, NM_001014432.1, NM_005163.2

e!Ensembl

Gene	ENSG00000142208
Transcript	ENST00000554581, ENST00000407796, ENST00000349310, ENST00000402615, ENST00000555528, ENST00000649815, ENST00000555458, ENST00000554192, ENST00000554585, ENST00000554848, ENST00000555926
Protein	ENSP00000451828, ENSP00000384293, ENSP00000270202, ENSP00000385326, ENSP00000450688, ENSP00000497822, ENSP00000451470, ENSP00000450681, ENSP00000481526, ENSP00000451166, ENSP00000451824

Gene Ontology (GO)

Show/Hide all(115 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001934	Biological process	Positive regulation of protein phosphorylation	IDA	19057511
GO:0001938	Biological process	Positive regulation of endothelial cell proliferation	IMP	19850054
GO:0002042	Biological process	Cell migration involved in sprouting angiogenesis	IMP	28341552
GO:0005979	Biological process	Regulation of glycogen biosynthetic process	IMP	8940145
GO:0006464	Biological process	Cellular protein modification process	TAS	10570282
GO:0006468	Biological process	Protein phosphorylation	IDA	11994271, 14749367, 23431171
GO:0006469	Biological process	Negative regulation of protein kinase activity	IMP	9373175
GO:0006606	Biological process	Protein import into nucleus	IMP	16280327
GO:0006809	Biological process	Nitric oxide biosynthetic process	TAS	10376602
GO:0006924	Biological process	Activation-induced cell death of T cells	IMP	14749367
GO:0007165	Biological process	Signal transduction	TAS	21432781
GO:0007173	Biological process	Epidermal growth factor receptor signaling pathway	IDA	20878056
GO:0007186	Biological process	G protein-coupled receptor signaling pathway	TAS	10570282
GO:0007249	Biological process	I-kappaB kinase/NF-kappaB signaling	IMP	26514923
GO:0008283	Biological process	Cell proliferation	TAS	21432781
GO:0008284	Biological process	Positive regulation of cell proliferation	IMP	10983986
GO:0008286	Biological process	Insulin receptor signaling pathway	IMP	8978681
GO:0009408	Biological process	Response to heat	TAS	10958679
GO:0010507	Biological process	Negative regulation of autophagy	IMP	18387192
GO:0010628	Biological process	Positive regulation of gene expression	IMP	28341552
GO:0010628	Biological process	Positive regulation of gene expression	ISS	18292230
GO:0010748	Biological process	Negative regulation of plasma membrane long-chain fatty acid transport	IMP	16814735
GO:0010907	Biological process	Positive regulation of glucose metabolic process	IMP	16814735
GO:0010918	Biological process	Positive regulation of mitochondrial membrane potential	IMP	10983986
GO:0010951	Biological process	Negative regulation of endopeptidase activity	IMP	18387192
GO:0014065	Biological process	Phosphatidylinositol 3-kinase signaling	IMP	26514923
GO:0016242	Biological process	Negative regulation of macroautophagy	NAS	23778976
GO:0016310	Biological process	Phosphorylation	IDA	20333297
GO:0018105	Biological process	Peptidyl-serine phosphorylation	IBA	21873635
GO:0018105	Biological process	Peptidyl-serine phosphorylation	IDA	16139227
GO:0018105	Biological process	Peptidyl-serine phosphorylation	TAS	21711983
GO:0018107	Biological process	Peptidyl-threonine phosphorylation	IDA	20605787
GO:0030154	Biological process	Cell differentiation	TAS	21432781
GO:0030307	Biological process	Positive regulation of cell growth	IDA	19203586
GO:0030334	Biological process	Regulation of cell migration	IMP	19934221
GO:0030334	Biological process	Regulation of cell migration	TAS	21432781
GO:0031397	Biological process	Negative regulation of protein ubiquitination	IMP	18292230
GO:0031929	Biological process	TOR signaling	NAS	23778976
GO:0031999	Biological process	Negative regulation of fatty acid beta-oxidation	IMP	16814735
GO:0032079	Biological process	Positive regulation of endodeoxyribonuclease activity	IDA	20605787
GO:0032091	Biological process	Negative regulation of protein binding	IMP	18292230
GO:0032869	Biological process	Cellular response to insulin stimulus	IMP	16814735
GO:0033138	Biological process	Positive regulation of peptidyl-serine phosphorylation	IDA	19667065
GO:0034405	Biological process	Response to fluid shear stress	IMP	10376603
GO:0034614	Biological process	Cellular response to reactive oxygen species	IMP	26514923
GO:0035556	Biological process	Intracellular signal transduction	IBA	21873635
GO:0035556	Biological process	Intracellular signal transduction	IDA	14749367
GO:0035655	Biological process	Interleukin-18-mediated signaling pathway	IDA	21321938
GO:0038061	Biological process	NIK/NF-kappaB signaling	IMP	26514923
GO:0043066	Biological process	Negative regulation of apoptotic process	IDA	19203586
GO:0043066	Biological process	Negative regulation of apoptotic process	IMP	10983986
GO:0043276	Biological process	Anoikis	NAS	23778976
GO:0043491	Biological process	Protein kinase B signaling	IMP	28341552
GO:0043536	Biological process	Positive regulation of blood vessel endothelial cell migration	IDA	20011604
GO:0045429	Biological process	Positive regulation of nitric oxide biosynthetic process	IMP	10376603
GO:0045600	Biological process	Positive regulation of fat cell differentiation	IMP	8940145
GO:0045725	Biological process	Positive regulation of glycogen biosynthetic process	IMP	16814735
GO:0045725	Biological process	Positive regulation of glycogen biosynthetic process	NAS	17925406
GO:0045737	Biological process	Positive regulation of cyclin-dependent protein serine/threonine kinase activity	IMP	18483258
GO:0045861	Biological process	Negative regulation of proteolysis	IMP	18387192
GO:0045893	Biological process	Positive regulation of transcription, DNA-templated	IMP	26514923
GO:0046326	Biological process	Positive regulation of glucose import	IMP	8940145, 16814735
GO:0046777	Biological process	Protein autophosphorylation	TAS	16280327
GO:0046889	Biological process	Positive regulation of lipid biosynthetic process	IMP	8940145
GO:0048009	Biological process	Insulin-like growth factor receptor signaling pathway	IMP	8978681
GO:0048661	Biological process	Positive regulation of smooth muscle cell proliferation	IDA	21321938
GO:0051000	Biological process	Positive regulation of nitric-oxide synthase activity	IMP	10376603
GO:0051091	Biological process	Positive regulation of DNA-binding transcription factor activity	IDA	19057511
GO:0060079	Biological process	Excitatory postsynaptic potential	NAS	21711983
GO:0060644	Biological process	Mammary gland epithelial cell differentiation	TAS	21432781
GO:0070141	Biological process	Response to UV-A	IDA	18483258
GO:0071276	Biological process	Cellular response to cadmium ion	IMP	26514923
GO:0071356	Biological process	Cellular response to tumor necrosis factor	IMP	10983986
GO:0071901	Biological process	Negative regulation of protein serine/threonine kinase activity	TAS	28386764
GO:0072655	Biological process	Establishment of protein localization to mitochondrion	IMP	23962723
GO:0072656	Biological process	Maintenance of protein location in mitochondrion	IMP	23962723
GO:0100002	Biological process	Negative regulation of protein kinase activity by protein phosphorylation	TAS	21711983
GO:0140052	Biological process	Cellular response to oxidised low-density lipoprotein particle stimulus	IMP	28341552
GO:1900087	Biological process	Positive regulation of G1/S transition of mitotic cell cycle	IMP	18483258
GO:1900182	Biological process	Positive regulation of protein localization to nucleus	IMP	20605787
GO:1901215	Biological process	Negative regulation of neuron death	NAS	18221368
GO:1902176	Biological process	Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	NAS	16604263
GO:1903038	Biological process	Negative regulation of leukocyte cell-cell adhesion	IMP	28341552
GO:1903078	Biological process	Positive regulation of protein localization to plasma membrane	IMP	8940145
GO:1903721	Biological process	Positive regulation of I-kappaB phosphorylation	IMP	26514923
GO:1990090	Biological process	Cellular response to nerve growth factor stimulus	IMP	20605787
GO:2000402	Biological process	Negative regulation of lymphocyte migration	IMP	28341552
GO:2001240	Biological process	Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	TAS	10748004
GO:0005634	Cellular component	Nucleus	IDA	20333297
GO:0005634	Cellular component	Nucleus	TAS	21432781
GO:0005737	Cellular component	Cytoplasm	IDA	19203586, 25190803
GO:0005737	Cellular component	Cytoplasm	TAS	21432781
GO:0005829	Cellular component	Cytosol	IDA	21045808
GO:0005886	Cellular component	Plasma membrane	IDA	14749367, 19203586, 20333297
GO:0005886	Cellular component	Plasma membrane	TAS	21432781
GO:0031982	Cellular component	Vesicle	IDA	16792529
GO:0032991	Cellular component	Protein-containing complex	IDA	10983986, 20878056
GO:0004672	Molecular function	Protein kinase activity	TAS	10570282
GO:0004674	Molecular function	Protein serine/threonine kinase activity	EXP	17030608
GO:0004674	Molecular function	Protein serine/threonine kinase activity	IBA	21873635
GO:0004674	Molecular function	Protein serine/threonine kinase activity	IDA	10102273, 10983986, 11994271, 16139227, 16540465, 19667065
GO:0004674	Molecular function	Protein serine/threonine kinase activity	NAS	28386764
GO:0004674	Molecular function	Protein serine/threonine kinase activity	TAS	21432781, 21711983
GO:0004712	Molecular function	Protein serine/threonine/tyrosine kinase activity	IDA	22797923
GO:0005515	Molecular function	Protein binding	IPI	10102273, 10983986, 11154276, 11438723, 11839802, 12176997, 12244133, 12791994, 16044149, 16139227, 16280327, 16282323, 16417524, 16525023, 16537421, 16792529, 17006541, 17577629, 17932490, 18191226, 18250332, 18292230, 18505846, 18562279, 18624398, 18650932, 18786403, 19162005, 191
GO:0005516	Molecular function	Calmodulin binding	IDA	29104511
GO:0005524	Molecular function	ATP binding	IC	11994271
GO:0005524	Molecular function	ATP binding	IDA	16540465
GO:0005547	Molecular function	Phosphatidylinositol-3,4,5-trisphosphate binding	IDA	19203586
GO:0016301	Molecular function	Kinase activity	IDA	14749367
GO:0030235	Molecular function	Nitric-oxide synthase regulator activity	IMP	10376603
GO:0042802	Molecular function	Identical protein binding	IPI	7891724, 17554339
GO:0042803	Molecular function	Protein homodimerization activity	IDA	10983986
GO:0043325	Molecular function	Phosphatidylinositol-3,4-bisphosphate binding	IDA	19203586
GO:0071889	Molecular function	14-3-3 protein binding	IPI	10102273

Protein Information

Protein Name

RAC-alpha serine/threonine-protein kinase, AKT1m, PKB alpha, RAC-PK-alpha, protein kinase B alpha, proto-oncogene c-Akt, rac protein kinase alpha, serine-threonine protein kinase, v-akt murine thymoma viral oncogene homolog 1, v-akt murine thymoma viral oncogene-like protein 1

Function

Refseq Proteins

NP_001014431.1, NP_001014432.1, NP_005154.2

UniProt

P31749

PDB

1H10, 1UNP, 1UNQ, 1UNR, 2UVM, 2UZR, 2UZS, 3CQU, 3CQW, 3MV5, 3MVH, 3O96, 3OCB, 3OW4, 3QKK, 3QKL, 3QKM, 4EJN, 4EKK, 4EKL, 4GV1, 5KCV, 6BUU, 6CCY, 6HHF, 6HHG, 6HHH, 6HHI, 6HHJ, 6NPZ

Pfam

Pfam Accession	Pfam ID
PF00169	PH
PF00069	Pkinase
PF00433	Pkinase_C