Liu Zhenteng, Liu Chang, Hao Cuifang, Xue Qianwen, Huang Xin, Zhang Ning, Bao Hongchu, Qu Qinglan

a Department of Reproductive Medicine , Yantai Yuhuangding Hospital, Affiliated Hospital of Medical College of Qingdao University , Yantai , Shandong , China .| b Medical College of Shandong University , Jinan , Shandong , China , and.| a Department of Reproductive Medicine , Yantai Yuhuangding Hospital, Affiliated Hospital of Medical College of Qingdao University , Yantai , Shandong , China .| c Department of Gynecology , Qingdao Women and Children Health Care Center , Qingdao , Shandong , China.| a Department of Reproductive Medicine , Yantai Yuhuangding Hospital, Affiliated Hospital of Medical College of Qingdao University , Yantai , Shandong , China .| a Department of Reproductive Medicine , Yantai Yuhuangding Hospital, Affiliated Hospital of Medical College of Qingdao University , Yantai , Shandong , China .| a Department of Reproductive Medicine , Yantai Yuhuangding Hospital, Affiliated Hospital of Medical College of Qingdao University , Yantai , Shandong , China .| a Department of Reproductive Medicine , Yantai Yuhuangding Hospital, Affiliated Hospital of Medical College of Qingdao University , Yantai , Shandong , China .

Gynecol Endocrinol. 2016 Jul;32(7):557-61. doi: 10.3109/09513590.2016.1138463.

Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder associated with obesity, insulin resistance, hyperandrogenism, alterations in ovarian angiogenesis and impaired oocyte competence. Emerging evidence demonstrates that angiopoietin-like protein 1 (ANGPTL1) and angiopoietin-like protein 2 (ANGPTL2) have an important influence on angiogenesis, androgen biosynthesis, insulin resistance and adipocytes function. In this study, we set out to determine the potential relationship between ANGPTL1, ANGPTL2 and oocyte competence in PCOS through analyzing the expression levels and dynamic pattern of the two genes in cumulus cells (CCs) during different phases of nuclear maturation of PCOS patients and control groups undergoing controlled ovarian hyperstimulation (COH) for in vitro fertilization and embryo transfer. We found that the relative abundance of ANGPTL1 and ANGPTL2 transcripts in CCs from patients with PCOS showed dynamic changes during oocyte maturation. Specifically, their expressions were increased significantly at the Metaphase II stage. In summary, the present novel evidence indicates that the expression patterns of ANGPTL1 and ANGPTL2 mRNAs are disordered during oocyte maturation in PCOS, which were potentially related to aberrant oocyte quality and developmental potency, at least in part, via pathological angiogenesis and metabolism.