ANXA5: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

ANXA5

Aliases

ANX5, ENX2, HEL-S-7, PP4, RPRGL3

Entrez Gene ID

308

Gene Name

Annexin A5

Chromosomal Location

4q27

HGNC ID

HGNC:543

Summary

The Annexin 5 gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa.The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. Polymorphisms in this gene have been implicated in various obstetric complications. [provided by RefSeq, Dec 2019]

RefSeq DNA

NG_032042.1

RefSeq mRNA

NM_001154.4

e!Ensembl

Gene	ENSG00000164111
Transcript	ENST00000296511, ENST00000501272, ENST00000506395, ENST00000515017, ENST00000513728
Protein	ENSP00000296511, ENSP00000424106, ENSP00000421421, ENSP00000424199, ENSP00000427135

Gene Ontology (GO)

Show/Hide all(29 )

GO ID	Ontology	Function	Evidence	Reference
GO:0007165	Biological process	Signal transduction	TAS	16130169
GO:0010033	Biological process	Response to organic substance	IBA	21873635
GO:0030195	Biological process	Negative regulation of blood coagulation	IBA	21873635
GO:0043065	Biological process	Positive regulation of apoptotic process	IBA	21873635
GO:0043066	Biological process	Negative regulation of apoptotic process	TAS	16130169
GO:0051283	Biological process	Negative regulation of sequestering of calcium ion	IBA	21873635
GO:0051592	Biological process	Response to calcium ion	IBA	21873635
GO:0071284	Biological process	Cellular response to lead ion	IBA	21873635
GO:0097066	Biological process	Response to thyroid hormone	IBA	21873635
GO:0097211	Biological process	Cellular response to gonadotropin-releasing hormone	IBA	21873635
GO:1901317	Biological process	Regulation of flagellated sperm motility	IBA	21873635
GO:1902721	Biological process	Negative regulation of prolactin secretion	IBA	21873635
GO:0005737	Cellular component	Cytoplasm	TAS	16130169
GO:0005925	Cellular component	Focal adhesion	HDA	21423176
GO:0016020	Cellular component	Membrane	HDA	19946888
GO:0016020	Cellular component	Membrane	IBA	21873635
GO:0062023	Cellular component	Collagen-containing extracellular matrix	HDA	28675934
GO:0062023	Cellular component	Collagen-containing extracellular matrix	HDA	28327460
GO:0070062	Cellular component	Extracellular exosome	HDA	19056867, 20458337, 21362503, 23533145
GO:0004859	Molecular function	Phospholipase inhibitor activity	TAS	2967495
GO:0005388	Molecular function	Calcium-transporting ATPase activity	IBA	21873635
GO:0005515	Molecular function	Protein binding	IBA	21873635
GO:0005515	Molecular function	Protein binding	IPI	21044950
GO:0005543	Molecular function	Phospholipid binding	TAS	2967291
GO:0005544	Molecular function	Calcium-dependent phospholipid binding	IBA	21873635
GO:0005544	Molecular function	Calcium-dependent phospholipid binding	IDA	2138016
GO:0008201	Molecular function	Heparin binding	IBA	21873635
GO:0017046	Molecular function	Peptide hormone binding	IBA	21873635
GO:0030971	Molecular function	Receptor tyrosine kinase binding	IBA	21873635

Protein Information

Protein Name

Annexin A5, CBP-I, PAP-I, VAC-alpha, anchorin CII, annexin V, annexin-5, calphobindin I, endonexin II, epididymis secretory protein Li 7, lipocortin V, placental anticoagulant protein 4, placental anticoagulant protein I, thromboplastin inhibitor, vascular anticoagulant-alpha

Function

This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade

Refseq Proteins

NP_001145.1

UniProt

P08758

PDB

1ANW, 1ANX, 1AVH, 1AVR, 1HAK, 1HVD, 1HVE, 1HVF, 1HVG, 1SAV, 2XO2, 2XO3

Pfam

Pfam Accession	Pfam ID
PF00191	Annexin