Gene Information
Gene Symbol
BTPS2, DP2, DP2.5, DP3, GS, PPP1R46
Entrez Gene ID
Gene Name
APC regulator of WNT signaling pathway
Chromosomal Location
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Dec 2019]
RefSeq DNA
RefSeq mRNA

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0000281 Biological process Mitotic cytokinesis IMP 17570218
GO:0001708 Biological process Cell fate specification IBA 21873635
GO:0006974 Biological process Cellular response to DNA damage stimulus IDA 14728717
GO:0007026 Biological process Negative regulation of microtubule depolymerization IBA 21873635
GO:0007026 Biological process Negative regulation of microtubule depolymerization IDA 11166179
Protein Information
Protein Name
Adenomatous polyposis coli protein, APC, WNT signaling pathway regulator, WNT signaling pathway regulator, adenomatosis polyposis coli tumor suppressor, adenomatous polyposis coli (APC), deleted in polyposis 2.5, epididymis secretory sperm binding protein, protein phosphatase 1, regulatory subunit 46, truncated adenomatosis polyposis coli
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
Refseq Proteins
Pfam Accession Pfam ID
PF05972 APC_15aa
PF05956 APC_basic
PF16689 APC_N_CC
PF05923 APC_r
PF00514 Arm
PF05937 EB1_binding
PF05924 SAMP

Wnt signaling pathway
Hippo signaling pathway
Signaling pathways regulating pluripotency of stem cells
Regulation of actin cytoskeleton
Cushing syndrome
Human papillomavirus infection
Pathways in cancer
MicroRNAs in cancer
Colorectal cancer
Endometrial cancer
Basal cell carcinoma
Breast cancer
Hepatocellular carcinoma
Gastric cancer


Apoptotic cleavage of cellular proteins
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Deactivation of the beta-catenin transactivating complex
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Misspliced GSK3beta mutants stabilize beta-catenin
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants are not K63 polyubiquitinated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Ovarian tumor domain proteases

ENSP00000255409 P36222
    View interactions

Associated Diseases

Disease groupDisease NameReferences
Blood Disorders
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Eye Abnormalities
Digestive System Diseases
Intestinal Polyposis
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
TAFI,plasminogen activator inhibitor-1 (PAI-1) ,fibrinogen,thrombomodulin,lipoproteins, thrombin-antithrombin (TAT) complexes, D-dimer, Protein C Antigen, Protein S Antigen, Antithrombin III (AT III) 

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