| |
| |
Gene Symbol |
APLNR |
| |
Aliases |
AGTRL1, APJ, APJR, HG11 |
| |
Entrez Gene ID |
|
| |
Gene Name |
Apelin receptor |
| |
Chromosomal Location |
11q12.1 |
| |
HGNC ID |
|
| |
Summary |
This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. [provided by RefSeq, Jul 2009]
|
| |
e!Ensembl
|
| Protein Information |
| |
Protein Name |
Apelin receptor, APJ (apelin) receptor, APJ receptor, G protein-coupled receptor APJ, G-protein coupled receptor HG11, HG11 orphan receptor, angiotensin II receptor-like 1, angiotensin receptor-like 1 |
| |
Function |
|
Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity (PubMed:11090199, PubMed:25639753, PubMed:28137936). Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone (By similarity). May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity). Plays also a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure (PubMed:25639753, PubMed:28137936). .; (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia (PubMed:11090199). |
|
| |
UniProt |
|
| |
PDB |
|
| |
Pfam |
| Pfam Accession |
Pfam ID |
| PF00001 |
7tm_1 |
|
|
|
|
|
|
Interactions |
| | |
| STRING |
MINT |
IntAct |
| ENSP00000384517 |
O00327 |
O00327 |
|
| | |
View interactions
|
| |
| |
Associated Diseases
| Disease group | Disease Name | References |
| Blood Disorders |
| Hypotension |
|
| Thrombopoiesis |
|
| Von Willebrand Disease |
|
| Cardiovascular Diseases |
| Cardiovascular Abnormalities |
|
| Heart Failure |
|
| Coronary heart disease |
|
| Heart Diseases |
|
| Ventricular Outflow Obstruction |
|
| Hypertensive disease |
27450650, 29800734, 28137936, 25438973, 20485192, 27338090, 24465893, 27863393, 22647782, 22498939, 23316219, 21654856 |
| Left Ventricular Hypertrophy |
|
| Atherosclerosis |
|
| Myocardial Ischemia |
|
| Left ventricular abnormality |
|
| Atrial Fibrillation |
|
| Aortic Valve Stenosis |
|
| Myocardial Infarction |
|
| Angina pectoris |
|
| Cardiac Arrest |
|
| Digestive System Diseases |
| Liver Cirrhosis |
|
| Fatty Liver |
|
| Gastrointestinal Diseases |
|
| Liver Fibrosis |
|
| Colitis |
|
| Hepatitis C |
|
| Ear Or Mastoid Diseases |
| Tinnitus |
|
| Endocrine System Diseases |
| PCOS |
|
| Diabetes Mellitus |
|
| Acromegaly |
|
| Eye Diseases |
| Disorder of eye |
|
| Diabetic Retinopathy |
|
| Diabetic Macular Edema |
|
| Corneal Neovascularization |
|
| Immune System Diseases |
| HIV Infections |
|
| AIDS |
|
| Musculoskeletal Diseases |
| Osteoarthritis |
|
| Neoplasms |
| Liver Cancer |
|
| Renal Cancer |
|
| Glioblastoma |
|
| Skin Fibrosis |
|
| Cholangiocarcinoma |
|
| Gastric Cancer |
|
| Lung Cancer |
|
| Hematopoietic Neoplasms |
|
| Multiple Myeloma |
|
| Colonic Neoplasms |
|
| Breast Cancer |
|
| Leukemia |
|
| Nervous System Diseases |
| Brain Infarction |
|
| Transient Ischemic Attack |
|
| Stroke |
|
| Degenerative Diseases Central Nervous System |
|
| Nutritional and Metabolic Diseases |
| Obesity |
|
| Hyperinsulinism |
|
| Psychiatric/Brain disorders |
| Alzheimer Disease |
|
| Renal Disorder |
| Albuminuria |
|
| Interstitial Cystitis |
|
| Diabetic Nephropathy |
|
| Renal Fibrosis |
|
| Reproductive disorders |
| Gestational Diabetes |
|
| Respiratory Tract Diseases |
| Asthma |
|
| Pulmonary Edema |
|
| Skin and Connective Tissue Diseases |
| Scleroderma |
|
| Bleeding Disorder |
|
| Psoriasis |
|
|
|
References |
| |
| |
| Temur Muzaffer, Yilmaz Ozgur, Aksun Saliha, Calan Mehmet, Ozun Ozbay Pelin, Kumbasar Serkan, Sever Erman |
| a Department of Obstetrics and Gynecology , Manisa Merkezefendi Hospital , Manisa , Turkey.| b Department of Obstetrics and Gynecology , Sakarya University Faculty of Medicine , Sakarya , Turkey.| c Manisa Merkezefendi State Hospital Department of Obstetrics and Gynecology , Manisa , Turkey.| d Department of Medical Biochemistry Izmir , Izmir Katipcelebi University Medical School , Izmir , Turkey.| e Department of Endocrinology Izmir , Izmir Bozyaka Education and Research Hospital , Izmir , Turkey.| f Aydin Private Ege Liva Hospital Department of Obstetrics and Gynecology Aydin , Aydin , Turkey , and.| g Department of Obstetrics and Gynecology , Sakarya University School of Medicine, Sakarya Research and Education Hospital , Sakarya , Turkey.| g Department of Obstetrics and Gynecology , Sakarya University School of Medicine, Sakarya Research and Education Hospital , Sakarya , Turkey. |
| Gynecol Endocrinol. 2017 Feb;33(2):124-127. doi: 10.1080/09513590.2016.1240772. |
Abstract
In this study, we aimed to compare the serum urocortin-2 (UCN2) levels in women with polycystic ovary syndrome (PCOS) and healthy women. Thirty-eight patients with PCOS and 41 healthy women were included in the study whose age and BMI matched. The fasting serum glucose, insulin, free testosterone, hs-CRP and UCN2 levels of the all participants were examined. HOMA-IR formula was used in order to calculate the insulin resistance. Circulating UCN2 levels were significantly elevated in women with PCOS compared with controls (142.93 +/- 59.48 versus 98.56 +/- 65.01 pg/ml, p = 0.002). FBG, serum insulin, hs-CRP and HOMA-IR levels were found to be increased in women with PCOS. There was a positive correlation between UCN2 and free-testosterone in only PCOS group (r = 0.235, p = 0.027). Multivariate logistic regression analyses revealed that the odds ratio for PCOS was 2.31 for patients in the highest quartile of UCN2 compared with those in the lowest quartile (OR = 2.31, 95% CI = 1.88-2.83, p=0.021). Multiple linear regression analysis revealed that HOMA-IR, hs-CRP and free-testosterone independently predicted UCN2 levels (p < 0.05). UCN2 levels were significantly higher in PCOS cases when compared to control group. UCN2 is thought to be effective on pathophysiology of PCOS by paracrine and autocrine pathways. |
|
|
|
| |
| © 2019, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
Tel: 91-22-24192104, Fax No: 91-22-24139412
|
