APOA4: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

APOA4

Aliases

Entrez Gene ID

337

Gene Name

Apolipoprotein A4

Chromosomal Location

11q23.3

HGNC ID

HGNC:602

Summary

Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_012044.1

RefSeq mRNA

NM_000482.4

e!Ensembl

Gene	ENSG00000110244
Transcript	ENST00000357780
Protein	ENSP00000350425

Gene Ontology (GO)

Show/Hide all(71 )

GO ID	Ontology	Function	Evidence	Reference
GO:0002227	Biological process	Innate immune response in mucosa	IDA	15254593
GO:0006695	Biological process	Cholesterol biosynthetic process	IBA	21873635
GO:0006869	Biological process	Lipid transport	IDA	1935934, 3095477
GO:0006982	Biological process	Response to lipid hydroperoxide	IDA	16945374
GO:0007159	Biological process	Leukocyte cell-cell adhesion	IDA	15254593
GO:0008203	Biological process	Cholesterol metabolic process	IDA	1935934
GO:0010873	Biological process	Positive regulation of cholesterol esterification	IBA	21873635
GO:0010873	Biological process	Positive regulation of cholesterol esterification	IDA	1935934
GO:0010898	Biological process	Positive regulation of triglyceride catabolic process	IBA	21873635
GO:0010898	Biological process	Positive regulation of triglyceride catabolic process	IDA	2307668
GO:0016042	Biological process	Lipid catabolic process	IDA	3095477
GO:0019430	Biological process	Removal of superoxide radicals	IDA	16945374
GO:0019433	Biological process	Triglyceride catabolic process	IBA	21873635
GO:0030300	Biological process	Regulation of intestinal cholesterol absorption	IBA	21873635
GO:0032374	Biological process	Regulation of cholesterol transport	IBA	21873635
GO:0032374	Biological process	Regulation of cholesterol transport	IDA	11940599
GO:0033344	Biological process	Cholesterol efflux	IBA	21873635
GO:0033344	Biological process	Cholesterol efflux	IDA	1935934, 11162594
GO:0033700	Biological process	Phospholipid efflux	IBA	21873635
GO:0033700	Biological process	Phospholipid efflux	IDA	11162594
GO:0034371	Biological process	Chylomicron remodeling	IC	2307668
GO:0034372	Biological process	Very-low-density lipoprotein particle remodeling	IBA	21873635
GO:0034372	Biological process	Very-low-density lipoprotein particle remodeling	IDA	2307668
GO:0034375	Biological process	High-density lipoprotein particle remodeling	IC	1935934
GO:0034378	Biological process	Chylomicron assembly	TAS	16159879
GO:0034380	Biological process	High-density lipoprotein particle assembly	IBA	21873635
GO:0034445	Biological process	Negative regulation of plasma lipoprotein oxidation	IDA	16945374
GO:0042157	Biological process	Lipoprotein metabolic process	IBA	21873635
GO:0042632	Biological process	Cholesterol homeostasis	IBA	21873635
GO:0042632	Biological process	Cholesterol homeostasis	IDA	1935934
GO:0042744	Biological process	Hydrogen peroxide catabolic process	IDA	16945374
GO:0043691	Biological process	Reverse cholesterol transport	IBA	21873635
GO:0043691	Biological process	Reverse cholesterol transport	IDA	3095477
GO:0045723	Biological process	Positive regulation of fatty acid biosynthetic process	IBA	21873635
GO:0045723	Biological process	Positive regulation of fatty acid biosynthetic process	IDA	2307668
GO:0046470	Biological process	Phosphatidylcholine metabolic process	IBA	21873635
GO:0046470	Biological process	Phosphatidylcholine metabolic process	IDA	1935934
GO:0046889	Biological process	Positive regulation of lipid biosynthetic process	IBA	21873635
GO:0051006	Biological process	Positive regulation of lipoprotein lipase activity	IBA	21873635
GO:0051006	Biological process	Positive regulation of lipoprotein lipase activity	IDA	2307668
GO:0055088	Biological process	Lipid homeostasis	IDA	3095477
GO:0065005	Biological process	Protein-lipid complex assembly	IMP	16159879
GO:0070328	Biological process	Triglyceride homeostasis	IBA	21873635
GO:0005576	Cellular component	Extracellular region	HDA	27068509
GO:0005576	Cellular component	Extracellular region	NAS	14718574
GO:0005615	Cellular component	Extracellular space	HDA	20551380
GO:0005615	Cellular component	Extracellular space	IDA	1935934
GO:0009986	Cellular component	Cell surface	IDA	1935934
GO:0034361	Cellular component	Very-low-density lipoprotein particle	IDA	3095477, 17154273
GO:0034364	Cellular component	High-density lipoprotein particle	IBA	21873635
GO:0034364	Cellular component	High-density lipoprotein particle	IDA	3095477
GO:0042627	Cellular component	Chylomicron	IBA	21873635
GO:0042627	Cellular component	Chylomicron	IDA	3095477
GO:0062023	Cellular component	Collagen-containing extracellular matrix	HDA	27559042
GO:0070062	Cellular component	Extracellular exosome	HDA	23533145
GO:0072562	Cellular component	Blood microparticle	HDA	22516433
GO:0005319	Molecular function	Lipid transporter activity	TAS	3080432
GO:0005507	Molecular function	Copper ion binding	IDA	16945374
GO:0005515	Molecular function	Protein binding	IPI	24311788
GO:0005543	Molecular function	Phospholipid binding	IBA	21873635
GO:0008289	Molecular function	Lipid binding	IMP	16159879
GO:0015485	Molecular function	Cholesterol binding	IBA	21873635
GO:0016209	Molecular function	Antioxidant activity	IDA	16945374
GO:0031210	Molecular function	Phosphatidylcholine binding	IBA	21873635
GO:0031210	Molecular function	Phosphatidylcholine binding	IDA	1935934, 11940599
GO:0042802	Molecular function	Identical protein binding	IPI	22579246
GO:0042803	Molecular function	Protein homodimerization activity	IDA	1935934
GO:0060228	Molecular function	Phosphatidylcholine-sterol O-acyltransferase activator activity	IBA	21873635
GO:0060228	Molecular function	Phosphatidylcholine-sterol O-acyltransferase activator activity	IDA	1935934
GO:0120020	Molecular function	Intermembrane cholesterol transfer activity	IBA	21873635
GO:0120020	Molecular function	Intermembrane cholesterol transfer activity	IDA	1935934

Protein Information

Protein Name

Apolipoprotein A-IV, apo-AIV, apoA-IV

Function

Refseq Proteins

NP_000473.2