APOC1: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

APOC1

Aliases

Apo-CI, ApoC-I, apo-CIB, apoC-IB

Entrez Gene ID

341

Gene Name

Apolipoprotein C1

Chromosomal Location

19q13.32

HGNC ID

HGNC:607

Summary

This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016]

RefSeq DNA

NG_012859.1

RefSeq mRNA

NM_001645.5, NM_001321065.2, NM_001321066.2

e!Ensembl

Gene	ENSG00000130208
Transcript	ENST00000588750, ENST00000588802, ENST00000592535, ENST00000592885, ENST00000589781, ENST00000589078, ENST00000590334, ENST00000586638, ENST00000592176
Protein	ENSP00000465356, ENSP00000468029, ENSP00000468276, ENSP00000467368, ENSP00000467504, ENSP00000465710, ENSP00000465190, ENSP00000466146, ENSP00000466227

Gene Ontology (GO)

Show/Hide all(26 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006629	Biological process	Lipid metabolic process	TAS	2897845
GO:0010873	Biological process	Positive regulation of cholesterol esterification	TAS	18992221
GO:0010900	Biological process	Negative regulation of phosphatidylcholine catabolic process	IDA	2302419
GO:0010916	Biological process	Negative regulation of very-low-density lipoprotein particle clearance	IDA	1917954
GO:0032374	Biological process	Regulation of cholesterol transport	IC	15576844
GO:0032375	Biological process	Negative regulation of cholesterol transport	IDA	10978346
GO:0033344	Biological process	Cholesterol efflux	IDA	11162594
GO:0033700	Biological process	Phospholipid efflux	IDA	11162594
GO:0034369	Biological process	Plasma lipoprotein particle remodeling	IDA	10978346
GO:0034375	Biological process	High-density lipoprotein particle remodeling	TAS	18992221
GO:0034379	Biological process	Very-low-density lipoprotein particle assembly	TAS	18992221
GO:0034382	Biological process	Chylomicron remnant clearance	IDA	4020294
GO:0034447	Biological process	Very-low-density lipoprotein particle clearance	IGI	15576844
GO:0045717	Biological process	Negative regulation of fatty acid biosynthetic process	IDA	15576844
GO:0045833	Biological process	Negative regulation of lipid metabolic process	IDA	182536
GO:0048261	Biological process	Negative regulation of receptor-mediated endocytosis	IDA	1917954
GO:0050995	Biological process	Negative regulation of lipid catabolic process	IDA	15576844
GO:0051005	Biological process	Negative regulation of lipoprotein lipase activity	IDA	15576844
GO:0034361	Cellular component	Very-low-density lipoprotein particle	IDA	15576844
GO:0034364	Cellular component	High-density lipoprotein particle	IDA	15576844
GO:0042627	Cellular component	Chylomicron	TAS	18992221
GO:0004859	Molecular function	Phospholipase inhibitor activity	IDA	2302419
GO:0005504	Molecular function	Fatty acid binding	IDA	17339654
GO:0031210	Molecular function	Phosphatidylcholine binding	TAS	2302419
GO:0055102	Molecular function	Lipase inhibitor activity	IDA	182536, 15576844
GO:0060228	Molecular function	Phosphatidylcholine-sterol O-acyltransferase activator activity	TAS	18992221

Protein Information

Protein Name

Apolipoprotein C-I

Function

Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.

Refseq Proteins

NP_001636.1, NP_001307994.1, NP_001307995.1

UniProt

P02654

PDB

1ALE, 1ALF, 1IOJ, 1OPP, 6DVU, 6DXR, 6DZ6, 6NF3

Pfam

Pfam Accession	Pfam ID
PF04691	ApoC-I