AQP9: Polycystic Ovarian Syndrome Database

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AQP9

Gene Information

Gene Ontology (GO)

Protein Information

Associated Diseases

Pathways

References

Gene Information

Gene Symbol

AQP9

Aliases

AQP-9, HsT17287, SSC1, T17287

Entrez Gene ID

366

Gene Name

Aquaporin 9

Chromosomal Location

15q21.3

HGNC ID

HGNC:643

Summary

The aquaporins are a family of water-selective membrane channels. This gene encodes a member of a subset of aquaporins called the aquaglyceroporins. This protein allows passage of a broad range of noncharged solutes and also stimulates urea transport and osmotic water permeability. This protein may also facilitate the uptake of glycerol in hepatic tissue . The encoded protein may also play a role in specialized leukocyte functions such as immunological response and bactericidal activity. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

RefSeq DNA

NG_011975.2

RefSeq mRNA

NM_020980.5, NM_001320635.2, NM_001320636.1

e!Ensembl

Gene	ENSG00000103569
Transcript	ENST00000558772, ENST00000219919, ENST00000536493
Protein	ENSP00000452673, ENSP00000219919, ENSP00000441390

Gene Ontology (GO)

Show/Hide all(28 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006833	Biological process	Water transport	IDA	9733774, 30420639
GO:0006863	Biological process	Purine nucleobase transport	IDA	9733774
GO:0006970	Biological process	Response to osmotic stress	TAS	9733774
GO:0007588	Biological process	Excretion	TAS	9733774
GO:0010033	Biological process	Response to organic substance	IDA	9733774
GO:0015791	Biological process	Polyol transport	IDA	9733774
GO:0015793	Biological process	Glycerol transport	IDA	30420639
GO:0015837	Biological process	Amine transport	IDA	9733774
GO:0015855	Biological process	Pyrimidine nucleobase transport	IDA	9733774
GO:0030104	Biological process	Water homeostasis	NAS	9733774
GO:0046689	Biological process	Response to mercury ion	IDA	9733774
GO:0046942	Biological process	Carboxylic acid transport	TAS	9733774
GO:0071320	Biological process	Cellular response to cAMP	IEP	17636236
GO:0071918	Biological process	Urea transmembrane transport	IMP	9514918
GO:0005887	Cellular component	Integral component of plasma membrane	IMP	9514918
GO:0016021	Cellular component	Integral component of membrane	NAS	9733774
GO:0043231	Cellular component	Intracellular membrane-bounded organelle	IDA	18718702
GO:0005275	Molecular function	Amine transmembrane transporter activity	TAS	9733774
GO:0005345	Molecular function	Purine nucleobase transmembrane transporter activity	IDA	9733774
GO:0005350	Molecular function	Pyrimidine nucleobase transmembrane transporter activity	IDA	9733774
GO:0005372	Molecular function	Water transmembrane transporter activity	TAS	9733774
GO:0015166	Molecular function	Polyol transmembrane transporter activity	TAS	9733774
GO:0015204	Molecular function	Urea transmembrane transporter activity	IBA	21873635
GO:0015250	Molecular function	Water channel activity	IDA	9733774, 30420639
GO:0015254	Molecular function	Glycerol channel activity	EXP	10564231, 18762715
GO:0015254	Molecular function	Glycerol channel activity	IDA	30420639
GO:0015265	Molecular function	Urea channel activity	IMP	9514918
GO:0046943	Molecular function	Carboxylic acid transmembrane transporter activity	TAS	9733774

Protein Information

Protein Name

Aquaporin-9, aquaglyceroporin-9, small solute channel 1

Function

Forms a water channel with a broad specificity. Also permeable glycerol and urea. Mediates passage of a wide variety of small, non-charged solutes including carbamides, polyols, purines, and pyrimidines.

Refseq Proteins

NP_066190.2, NP_001307564.1, NP_001307565.1

UniProt

O43315

Pfam

Pfam Accession	Pfam ID
PF00230	MIP

Pathways
	KEGG	Reactome
	Bile secretion	Transport of glycerol from adipocytes to the liver by Aquaporins Passive transport by Aquaporins

Interactions

STRING	MINT	IntAct
ENSP00000398736	O00622	O00622

View interactions

Associated Diseases

Show/Hide all(4 )

Disease group	Disease Name	References
Endocrine System Diseases
Endocrine System Diseases	PCOS	17924462
Immune System Diseases
	Juvenile arthritis	19565504
	Still Disease	19565504
Neoplasms
	Myeloid Leukemia	16968895
	Leukemia	15336539, 16968895, 23563754
Nervous System Diseases
Nervous System Diseases	Arsenic Encephalopathy	19805235

References

PMID: 17924462

[Expression of aquaporin 9 in granulosa cells of patients with polycystic ovary syndrome in IVF-cycles].

Lu Xiu-e, Qian Yu-li, Huang He-feng

The Affiliated Obstetrics and Gynecology Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China.

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2007 Sep;36(5):449-53.

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