ARHGAP4: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

ARHGAP4

Aliases

C1, RGC1, RhoGAP4, SrGAP4, p115

Entrez Gene ID

393

Gene Name

Rho GTPase activating protein 4

Chromosomal Location

Xq28

HGNC ID

HGNC:674

Summary

This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

RefSeq DNA

NG_013220.1

RefSeq mRNA

NM_001666.5, NM_001164741.2

e!Ensembl

Gene	ENSG00000089820
Transcript	ENST00000393721, ENST00000370028, ENST00000420383, ENST00000350060, ENST00000370016, ENST00000404127, ENST00000454164, ENST00000442172, ENST00000422918, ENST00000461052, ENST00000418750, ENST00000488269, ENST00000442262, ENST00000422091
Protein	ENSP00000377322, ENSP00000359045, ENSP00000397533, ENSP00000203786, ENSP00000359033, ENSP00000385042, ENSP00000412437, ENSP00000408656, ENSP00000398019, ENSP00000473840, ENSP00000411712, ENSP00000473936, ENSP00000398259, ENSP00000413782

Gene Ontology (GO)

Show/Hide all(7 )

GO ID	Ontology	Function	Evidence	Reference
GO:0007010	Biological process	Cytoskeleton organization	TAS	8570618
GO:0007266	Biological process	Rho protein signal transduction	TAS	8570618
GO:0030336	Biological process	Negative regulation of cell migration	IBA	21873635
GO:0005737	Cellular component	Cytoplasm	IBA	21873635
GO:0005070	Molecular function	SH3/SH2 adaptor activity	TAS	8570618
GO:0005515	Molecular function	Protein binding	IPI	16417406
GO:0048365	Molecular function	Rac GTPase binding	IBA	21873635

Protein Information

Protein Name

Rho GTPase-activating protein 4, Rho-GAP hematopoietic protein C1, rho-type GTPase-activating protein 4

Function

Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells

Refseq Proteins

NP_001657.3, NP_001158213.1

UniProt

P98171

PDB

2EPD

Pfam

Pfam Accession	Pfam ID
PF00611	FCH
PF00620	RhoGAP
PF00018	SH3_1