ARHGAP9: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

ARHGAP9

Aliases

10C, RGL1

Entrez Gene ID

64333

Gene Name

Rho GTPase activating protein 9

Chromosomal Location

12q13.3

HGNC ID

HGNC:14130

Summary

This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_023205.2

RefSeq mRNA

NM_032496.4, NM_001080156.3, NM_001080157.2, NM_001319850.2, NM_001319851.2, NM_001319852.2, NM_001367422.1, NM_001367423.1, NM_001367424.1, NM_001367425.1, NM_001367426.1

e!Ensembl

Gene	ENSG00000123329
Transcript	ENST00000424809, ENST00000393797, ENST00000550399, ENST00000550288, ENST00000393791, ENST00000430041, ENST00000550130, ENST00000548139, ENST00000552604, ENST00000551452, ENST00000552066, ENST00000549602, ENST00000552249, ENST00000670128
Protein	ENSP00000394307, ENSP00000377386, ENSP00000448404, ENSP00000473445, ENSP00000377380, ENSP00000397950, ENSP00000448423, ENSP00000449829, ENSP00000450256, ENSP00000446932, ENSP00000448424, ENSP00000450223, ENSP00000448358, ENSP00000499232

Gene Ontology (GO)

Show/Hide all(5 )

GO ID	Ontology	Function	Evidence	Reference
GO:0043087	Biological process	Regulation of GTPase activity	IBA	21873635
GO:0005737	Cellular component	Cytoplasm	IBA	21873635
GO:0005096	Molecular function	GTPase activator activity	IDA	11396949
GO:0005515	Molecular function	Protein binding	IPI	25416956
GO:0005547	Molecular function	Phosphatidylinositol-3,4,5-trisphosphate binding	IDA	17339315

Protein Information

Protein Name

Rho GTPase-activating protein 9, rho-type GTPase-activating protein 9

Function

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate.

Refseq Proteins

NP_115885.2, NP_001073625.1, NP_001073626.1, NP_001306779.2, NP_001306780.1, NP_001306781.1, NP_001354351.1, NP_001354352.1, NP_001354353.1, NP_001354354.1, NP_001354355.1

UniProt

Q9BRR9

PDB

2P0D, 2P0F, 2P0H

Pfam

Pfam Accession	Pfam ID
PF00169	PH
PF00620	RhoGAP
PF00018	SH3_1