ARID4B: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

ARID4B

Aliases

BCAA, BRCAA1, RBBP1L1, RBP1L1, SAP180

Entrez Gene ID

51742

Gene Name

AT-rich interaction domain 4B

Chromosomal Location

1q42.3

HGNC ID

HGNC:15550

Summary

This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_029484.1

RefSeq mRNA

NM_016374.6, NR_135074.2, NM_031371.4, NM_001206794.1

e!Ensembl

Gene	ENSG00000054267
Transcript	ENST00000474953, ENST00000366603, ENST00000349213, ENST00000264183, ENST00000421364, ENST00000444620, ENST00000418304
Protein	ENSP00000420620, ENSP00000355562, ENSP00000264184, ENSP00000264183, ENSP00000394663, ENSP00000416063, ENSP00000391497

Gene Ontology (GO)

Show/Hide all(4 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006357	Biological process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0005634	Cellular component	Nucleus	IBA	21873635
GO:0005515	Molecular function	Protein binding	IPI	20195357
GO:0044212	Molecular function	Transcription regulatory region DNA binding	IBA	21873635

Protein Information

Protein Name

AT-rich interactive domain-containing protein 4B, 180 kDa Sin3-associated polypeptide, ARID domain-containing protein 4B, AT rich interactive domain 4B (RBP1-like), Rb-binding protein homolog, SIN3A-associated protein 180, breast cancer-associated antigen 1, breast cancer-associated antigen BRCAA1, breast carcinoma-associated antigen, histone deacetylase complex subunit SAP180, retinoblastoma-binding protein 1-like 1, sin3-associated polypeptide p180

Function

Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity).

Refseq Proteins

NP_057458.4, , NP_112739.2, NP_001193723.1

UniProt

Q4LE39