ATF4: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

ATF4

Aliases

CREB-2, CREB2, TAXREB67, TXREB

Entrez Gene ID

468

Gene Name

Activating transcription factor 4

Chromosomal Location

22q13.1

HGNC ID

HGNC:786

Summary

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]

e!Ensembl

Gene	ENSG00000128272
Transcript	ENST00000404241, ENST00000337304, ENST00000396680
Protein	ENSP00000384587, ENSP00000336790, ENSP00000379912

Gene Ontology (GO)

Show/Hide all(55 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006357	Biological process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0006520	Biological process	Cellular amino acid metabolic process	TAS	12689582
GO:0010575	Biological process	Positive regulation of vascular endothelial growth factor production	IMP	22915762
GO:0010628	Biological process	Positive regulation of gene expression	IMP	24136195, 24939851
GO:0034976	Biological process	Response to endoplasmic reticulum stress	IDA	19061639
GO:0034976	Biological process	Response to endoplasmic reticulum stress	IMP	24939851
GO:0036003	Biological process	Positive regulation of transcription from RNA polymerase II promoter in response to stress	IC	25681212
GO:0036091	Biological process	Positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress	IBA	21873635
GO:0036091	Biological process	Positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress	IMP	21113145
GO:0036091	Biological process	Positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress	ISS	23392669
GO:0036499	Biological process	PERK-mediated unfolded protein response	TAS	22013210, 22934019
GO:0042149	Biological process	Cellular response to glucose starvation	IMP	22915762
GO:0043065	Biological process	Positive regulation of apoptotic process	TAS	23392669
GO:0045893	Biological process	Positive regulation of transcription, DNA-templated	IDA	15775988, 18940792
GO:0045893	Biological process	Positive regulation of transcription, DNA-templated	IMP	11960987
GO:0045893	Biological process	Positive regulation of transcription, DNA-templated	NAS	9190894
GO:0045943	Biological process	Positive regulation of transcription by RNA polymerase I	IMP	22915762
GO:0045944	Biological process	Positive regulation of transcription by RNA polymerase II	IDA	11478948, 15775988, 18940792
GO:0045944	Biological process	Positive regulation of transcription by RNA polymerase II	IMP	15788408
GO:0061395	Biological process	Positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance	TAS	14685163
GO:0120163	Biological process	Negative regulation of cold-induced thermogenesis	ISS	22980225
GO:1903204	Biological process	Negative regulation of oxidative stress-induced neuron death	IGI	23392669
GO:1903351	Biological process	Cellular response to dopamine	IMP	24136195
GO:1990440	Biological process	Positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	IBA	21873635
GO:1990440	Biological process	Positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	IDA	12871976
GO:1990440	Biological process	Positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	IMP	21113145
GO:0005634	Cellular component	Nucleus	IBA	21873635
GO:0005634	Cellular component	Nucleus	IDA	11478948, 16682973, 23392669
GO:0005737	Cellular component	Cytoplasm	IDA	23392669
GO:0005813	Cellular component	Centrosome	IDA	20873783
GO:0032991	Cellular component	Protein-containing complex	IDA	20873783
GO:0034399	Cellular component	Nuclear periphery	IDA	23392669
GO:0043005	Cellular component	Neuron projection	IDA	23392669
GO:1990037	Cellular component	Lewy body core	IDA	23392669
GO:1990589	Cellular component	ATF4-CREB1 transcription factor complex	IDA	12871976
GO:1990590	Cellular component	ATF1-ATF4 transcription factor complex	IDA	12871976
GO:1990617	Cellular component	CHOP-ATF4 complex	IDA	11478948
GO:1990617	Cellular component	CHOP-ATF4 complex	IPI	18940792
GO:1990617	Cellular component	CHOP-ATF4 complex	NAS	15775988
GO:0000977	Molecular function	RNA polymerase II regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	11478948, 12871976
GO:0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISM	19274049
GO:0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific	NAS	19274049
GO:0001085	Molecular function	RNA polymerase II transcription factor binding	IPI	11478948
GO:0003677	Molecular function	DNA binding	IDA	15788408, 18940792
GO:0003700	Molecular function	DNA-binding transcription factor activity	TAS	12689582
GO:0005515	Molecular function	Protein binding	IPI	9488481, 11238952, 12743605, 12812986, 12860379, 15677469, 16169070, 16189514, 16343488, 16682973, 18330356, 18940792, 19164757, 19447967, 20102225, 20936779, 21408167, 21988832, 25241761, 25416956, 25910212, 26700459, 26871637
GO:0019901	Molecular function	Protein kinase binding	IPI	20873783
GO:0043522	Molecular function	Leucine zipper domain binding	IDA	11478948
GO:0043565	Molecular function	Sequence-specific DNA binding	IDA	22915762
GO:0044212	Molecular function	Transcription regulatory region DNA binding	IDA	21113145
GO:0044212	Molecular function	Transcription regulatory region DNA binding	IDA	12871976
GO:0044212	Molecular function	Transcription regulatory region DNA binding	TAS	23392669
GO:0046982	Molecular function	Protein heterodimerization activity	NAS	15775988

Protein Information

Protein Name

Cyclic AMP-dependent transcription factor ATF-4, DNA-binding protein TAXREB67, cAMP response element-binding protein 2, cAMP-dependent transcription factor ATF-4, cAMP-responsive element-binding protein 2, cyclic AMP-responsive element-binding protein 2, tax-responsive enhancer element B67, tax-responsive enhancer element-binding protein 67

Function

UniProt

P18848

PDB

1CI6

Pfam

Pfam Accession	Pfam ID
PF00170	bZIP_1