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Gene Symbol |
BDNF |
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Aliases |
ANON2, BULN2 |
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Entrez Gene ID |
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Gene Name |
Brain derived neurotrophic factor |
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Chromosomal Location |
11p14.1 |
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HGNC ID |
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Summary |
This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. [provided by RefSeq, Nov 2015]
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RefSeq DNA |
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RefSeq mRNA |
NM_170731.4, NM_001709.5, NM_170731.5, NM_170732.4, NM_170733.3, NM_170734.3, NM_170735.5, NM_001143805.1, NM_001143806.1, NM_001143807.2, NM_001143808.1, NM_001143809.1, NM_001143810.1, NM_001143811.1, NM_001143812.1, NM_001143813.2, NM_001143814.2, NM_001143816.1 |
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e!Ensembl
| Gene |
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| Transcript |
ENST00000439476, ENST00000525528, ENST00000395986, ENST00000533131, ENST00000356660, ENST00000418212, ENST00000533246, ENST00000530861, ENST00000530786, ENST00000395983, ENST00000438929, ENST00000532997, ENST00000395981, ENST00000395978, ENST00000525950, ENST00000314915, ENST00000395980, ENST00000420794 |
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| Protein |
ENSP00000389345, ENSP00000437138, ENSP00000379309, ENSP00000432727, ENSP00000349084, ENSP00000400502, ENSP00000432376, ENSP00000435564, ENSP00000433003, ENSP00000379307, ENSP00000414303, ENSP00000435805, ENSP00000379305, ENSP00000379302, ENSP00000432035, ENSP00000320002, ENSP00000379304, ENSP00000389564
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| Protein Information |
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Protein Name |
Brain-derived neurotrophic factor, abrineurin, neurotrophin |
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Function |
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Important signaling molecule that activates signaling cascades downstream of NTRK2. During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. [BDNF precursor form]: Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2 (PubMed:24908487, PubMed:29909994). Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse (By similarity) |
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NP_733927.1, NP_001700.2, NP_733928.1, NP_733929.1, NP_733930.1, NP_733931.1, NP_001137277.1, NP_001137278.1, NP_001137279.1, NP_001137280.1, NP_001137281.1, NP_001137282.1, NP_001137283.1, NP_001137284.1, NP_001137285.1, NP_001137286.1, NP_001137288.1
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UniProt |
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PDB |
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Interactions |
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| STRING |
MINT |
IntAct |
| ENSP00000379683 |
P11511 |
P11511 |
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View interactions
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Associated Diseases
| Disease group | Disease Name | References |
| Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| Atonic seizures |
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| Congenital central hypoventilation |
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| Haddad syndrome |
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| Ear Or Mastoid Diseases |
| Deafness |
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| Endocrine System Diseases |
| PCOS |
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| Neoplasms |
| Gastric Cancer |
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| Stomach Cancer |
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| Nervous System Diseases |
| Seizures |
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| Status Epilepticus |
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| Epilepsy |
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| Cerebral Ischemia |
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| Petit mal status |
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| Jacksonian Seizure |
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| Parkinson Disease |
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| Nutritional and Metabolic Diseases |
| Obesity |
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| Psychiatric/Brain disorders |
| Mental Depression |
19018715, 14708030, 25044977, 22801293, 24577123, 25510949, 25658497, 16330021, 21945287, 25283187, 22931410, 25277075, 25422957, 23208077, 18301726, 19358977 |
| Autistic Disorder |
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| Intellectual Disability |
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| Bipolar Disorder |
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| Mood Disorders |
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| Melancholia |
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| Schizophrenia |
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| Psychosis |
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| Manic Disorder |
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| Alzheimer Disease |
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| Senile Dementia |
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| Schizophreniform Disorders |
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| Schizoaffective Disorder |
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| Eating Disorders |
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| Obstructive Sleep Apnea |
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| Reproductive disorders |
| Preeclampsia |
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References |
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| Russo N, Russo M, Daino D, Bucci F, Pluchino N, Casarosa E, Artini P G, Cela V, Luisi M, Genazzani A R |
| Department of Reproductive Medicine and Child Development, Division of Gynaecology and Obstetrics, University of Pisa, Pisa, Italy. nataliarusso@libero.it |
| Gynecol Endocrinol. 2012 Apr;28(4):241-4. doi: 10.3109/09513590.2011.613969. |
Abstract
Polycystic ovary syndrome is one of the most common endocrine disorders in women of reproductive age. Features of PCOS are hyperandrogenism, chronic anovulation and polycystic ovaries on ultrasonography. Follicle development is a complex and carefully orchestrated phenomenon, involving gonadotropins and a rapidly expanding list of other intraovarian regulators, such as brain-derived neurotrophic factor (BDNF). The aim of this study is to evaluate BDNF in plasma and in follicular fluid in women affected by PCOS and in normal menstruating women. In PCOS patients the BDNF levels in plasma and in follicular fluid are higher than values obtained in healthy controls. Therefore we can hypothsize that high levels of luteinizing hormone, probably increase the secretion of BDNF in PCOS patients. |
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