BGLAP: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

BGLAP

Aliases

BGP, OC, OCN

Entrez Gene ID

632

Gene Name

Bone gamma-carboxyglutamate protein

Chromosomal Location

1q22

HGNC ID

HGNC:1043

Summary

This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]

RefSeq DNA

NG_047015.1

RefSeq mRNA

NM_199173.6

e!Ensembl

Gene	ENSG00000242252
Transcript	ENST00000368272
Protein	ENSP00000357255

Gene Ontology (GO)

Show/Hide all(18 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001501	Biological process	Skeletal system development	TAS	10865224
GO:0001503	Biological process	Ossification	IBA	21873635
GO:0001649	Biological process	Osteoblast differentiation	IBA	21873635
GO:0001649	Biological process	Osteoblast differentiation	IEP	17023519
GO:0007155	Biological process	Cell adhesion	NAS	12202187
GO:0030282	Biological process	Bone mineralization	NAS	10486212
GO:0033280	Biological process	Response to vitamin D	IEP	17023519
GO:0045124	Biological process	Regulation of bone resorption	NAS	10486212
GO:0045670	Biological process	Regulation of osteoclast differentiation	NAS	10486212
GO:0060348	Biological process	Bone development	IBA	21873635
GO:0005576	Cellular component	Extracellular region	IBA	21873635
GO:0005737	Cellular component	Cytoplasm	IDA	11856645
GO:0005198	Molecular function	Structural molecule activity	NAS	10486212
GO:0005509	Molecular function	Calcium ion binding	IBA	21873635
GO:0008147	Molecular function	Structural constituent of bone	IBA	21873635
GO:0008147	Molecular function	Structural constituent of bone	NAS	12467198
GO:0046848	Molecular function	Hydroxyapatite binding	IBA	21873635
GO:0046848	Molecular function	Hydroxyapatite binding	NAS	10486212

Protein Information

Protein Name

Osteocalcin, bone gamma-carboxyglutamate (gla) protein (osteocalcin), gamma-carboxyglutamic acid-containing protein

Function

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium

Refseq Proteins

NP_954642.1

UniProt

P02818