CALCA: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

CALCA

Aliases

CALC1, CGRP, CGRP-I, CGRP1, CT, KC, PCT

Entrez Gene ID

796

Gene Name

Calcitonin related polypeptide alpha

Chromosomal Location

11p15.2

HGNC ID

HGNC:1437

Summary

This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]

RefSeq DNA

NG_015960.1

RefSeq mRNA

NR_125898.2, NM_001741.3, NM_001033953.2, NM_001033952.2

e!Ensembl

Gene	ENSG00000110680
Transcript	ENST00000486207, ENST00000469608, ENST00000331587, ENST00000396372, ENST00000361010
Protein	ENSP00000417833, ENSP00000420618, ENSP00000331746, ENSP00000379657, ENSP00000354286

Gene Ontology (GO)

Show/Hide all(16 )

GO ID	Ontology	Function	Evidence	Reference
GO:0002548	Biological process	Monocyte chemotaxis	IDA	15248232
GO:0007189	Biological process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007189	Biological process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	8078488, 11014233
GO:0007204	Biological process	Positive regulation of cytosolic calcium ion concentration	IDA	17983652
GO:0007566	Biological process	Embryo implantation	IDA	17983652
GO:0032147	Biological process	Activation of protein kinase activity	IDA	17983652
GO:0045779	Biological process	Negative regulation of bone resorption	IDA	17241109
GO:0045892	Biological process	Negative regulation of transcription, DNA-templated	IDA	11014233
GO:0051480	Biological process	Regulation of cytosolic calcium ion concentration	IBA	21873635
GO:0051482	Biological process	Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	IDA	8078488
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0005615	Cellular component	Extracellular space	IDA	18057382
GO:0005515	Molecular function	Protein binding	IPI	17689535
GO:0031716	Molecular function	Calcitonin receptor binding	IBA	21873635
GO:0031716	Molecular function	Calcitonin receptor binding	IPI	8078488, 8940110
GO:0042802	Molecular function	Identical protein binding	IPI	23395606

Protein Information

Protein Name

Calcitonin, calcitonin gene-related peptide 1, alpha-type CGRP, calcitonin 1, calcitonin gene-related peptide I, calcitonin/calcitonin-related polypeptide, alpha, katacalcin

Function

CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.

Refseq Proteins

, NP_001732.1, NP_001029125.1, NP_001029124.1

UniProt

P01258

PDB

1LS7, 6E3Y, 2JXZ

Pfam

Pfam Accession	Pfam ID
PF00214	Calc_CGRP_IAPP