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Gene Symbol |
CCN1 |
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Aliases |
CYR61, GIG1, IGFBP10 |
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Entrez Gene ID |
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Gene Name |
Cellular communication network factor 1 |
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Chromosomal Location |
1p22.3 |
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HGNC ID |
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Summary |
The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]
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e!Ensembl
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| Protein Information |
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Protein Name |
CCN family member 1, IBP-10, IGF-binding protein 10, IGFBP-10, cysteine rich angiogenic inducer 61, cysteine-rich heparin-binding protein 61, cysteine-rich, anigogenic inducer, 61, insulin-like growth factor-binding protein 10, protein CYR61 |
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Function |
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Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. |
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UniProt |
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PDB |
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Interactions |
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| STRING |
MINT |
IntAct |
| ENSP00000367942 |
O60383 |
O60383 |
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View interactions
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Associated Diseases
| Disease group | Disease Name | References |
| Endocrine System Diseases |
| PCOS |
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| Immune System Diseases |
| Rheumatoid Arthritis |
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| Neoplasms |
| Liver Cancer |
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| Lung Cancer |
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| Nutritional and Metabolic Diseases |
| Gluocose Intolerance |
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References |
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| MacLaughlan Shannon D, Palomino Wilder A, Mo Bilan, Lewis Terrence D, Lininger Ruth A, Lessey Bruce A |
| Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA. |
| Obstet Gynecol. 2007 Jul;110(1):146-54. doi: 10.1097/01.AOG.0000269047.46078.28. |
Abstract
OBJECTIVE: To compare the expression of Cyr61 in normal cycling endometrium with endometrium from women with polycystic ovarian syndrome (PCOS) and endometrial hyperplasia and adenocarcinoma. METHODS: This is a retrospective study of 59 samples of normal and abnormal endometrium. Endometrial biopsies were obtained from normal fertile controls throughout the menstrual cycle and compared with endometrium from ovulatory and anovulatory women with PCOS and complex endometrial hyperplasia and endometrioid adenocarcinoma. Cyr61 expression was evaluated by using immunohistochemistry and reverse transcription PCR for Cyr61, estrogen receptor (ER)-alpha, a marker of cell proliferation (Ki67), and another marker of early estrogen action, cFos. Regulation of Cyr61 protein was studied in a steroid-responsive endometrial carcinoma cell line, ECC1. RESULTS: Cyr61 protein was regulated by estrogen. In normal endometrium, Cyr61 was highest in the proliferative phase and lowest in the normal midsecretory phase. In contrast, elevated levels of Cyr61, ER-alpha, Ki67, and cFos were all found in the midsecretory endometrium of ovulatory PCOS patients, endometrial cancer patients, and hyperplasia patients. CONCLUSION: Cyr61 is overexpressed in PCOS endometrium, reflecting a heightened responsiveness to estrogen. As a unique marker of estrogen action, Cyr61 may be an early biomarker for the development of hyperplasia or adenocarcinoma in this group of women. |
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