CD14: Polycystic Ovarian Syndrome Database

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CD14

Gene Information

Gene Ontology (GO)

Protein Information

Associated Diseases

Pathways

References

Gene Information

Gene Symbol

CD14

Aliases

Entrez Gene ID

929

Gene Name

CD14 molecule

Chromosomal Location

5q31.3

HGNC ID

HGNC:1628

Summary

The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]

RefSeq DNA

NG_023178.1

RefSeq mRNA

NM_001040021.3, NM_000591.4, NM_001174104.1, NM_001174105.2

e!Ensembl

Gene	ENSG00000170458
Transcript	ENST00000302014, ENST00000498971, ENST00000519715, ENST00000512545, ENST00000401743
Protein	ENSP00000304236, ENSP00000426543, ENSP00000430884, ENSP00000425447, ENSP00000385519

Gene Ontology (GO)

Show/Hide all(39 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006909	Biological process	Phagocytosis	TAS	9548256
GO:0006915	Biological process	Apoptotic process	TAS	9548256
GO:0006954	Biological process	Inflammatory response	IBA	21873635
GO:0007166	Biological process	Cell surface receptor signaling pathway	TAS	8798531
GO:0031663	Biological process	Lipopolysaccharide-mediated signaling pathway	IBA	21873635
GO:0032481	Biological process	Positive regulation of type I interferon production	IBA	21873635
GO:0032729	Biological process	Positive regulation of interferon-gamma production	IBA	21873635
GO:0032760	Biological process	Positive regulation of tumor necrosis factor production	IDA	12594207, 15294986
GO:0032760	Biological process	Positive regulation of tumor necrosis factor production	IMP	8612135
GO:0034142	Biological process	Toll-like receptor 4 signaling pathway	IBA	21873635
GO:0050715	Biological process	Positive regulation of cytokine secretion	IBA	21873635
GO:0071219	Biological process	Cellular response to molecule of bacterial origin	IDA	15039339
GO:0071222	Biological process	Cellular response to lipopolysaccharide	IBA	21873635
GO:0071222	Biological process	Cellular response to lipopolysaccharide	IDA	12594207
GO:0071222	Biological process	Cellular response to lipopolysaccharide	IMP	8612135
GO:0071223	Biological process	Cellular response to lipoteichoic acid	IDA	12594207
GO:0071726	Biological process	Cellular response to diacyl bacterial lipopeptide	IDA	16880211
GO:0071727	Biological process	Cellular response to triacyl bacterial lipopeptide	IDA	16880211
GO:1901224	Biological process	Positive regulation of NIK/NF-kappaB signaling	IBA	21873635
GO:1901224	Biological process	Positive regulation of NIK/NF-kappaB signaling	IDA	15294986
GO:2000484	Biological process	Positive regulation of interleukin-8 secretion	IBA	21873635
GO:2000484	Biological process	Positive regulation of interleukin-8 secretion	IMP	15039339
GO:0005615	Cellular component	Extracellular space	HDA	16502470
GO:0005794	Cellular component	Golgi apparatus	IDA	16880211
GO:0009897	Cellular component	External side of plasma membrane	IBA	21873635
GO:0009986	Cellular component	Cell surface	IBA	21873635
GO:0031362	Cellular component	Anchored component of external side of plasma membrane	IDA	3385210
GO:0045121	Cellular component	Membrane raft	IBA	21873635
GO:0045121	Cellular component	Membrane raft	IDA	16880211
GO:0046696	Cellular component	Lipopolysaccharide receptor complex	IBA	21873635
GO:0046696	Cellular component	Lipopolysaccharide receptor complex	IDA	11274165
GO:0070062	Cellular component	Extracellular exosome	HDA	19056867, 19199708, 23533145
GO:0001530	Molecular function	Lipopolysaccharide binding	IBA	21873635
GO:0001530	Molecular function	Lipopolysaccharide binding	IDA	12594207
GO:0001847	Molecular function	Opsonin receptor activity	TAS	2402637
GO:0005515	Molecular function	Protein binding	IPI	16880211, 20860622, 22265692, 25965346
GO:0016019	Molecular function	Peptidoglycan receptor activity	TAS	8798531
GO:0070891	Molecular function	Lipoteichoic acid binding	IDA	12594207
GO:0071723	Molecular function	Lipopeptide binding	IDA	15294986

Protein Information

Protein Name

Monocyte differentiation antigen CD14, myeloid cell-specific leucine-rich glycoprotein

Function

Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-)

Refseq Proteins

NP_001035110.1, NP_000582.1, NP_001167575.1, NP_001167576.1

UniProt

P08571

PDB

4GLP

Pathways
	KEGG	Reactome
	MAPK signaling pathway NF-kappa B signaling pathway Phagosome Toll-like receptor signaling pathway Hematopoietic cell lineage Pathogenic Escherichia coli infection Salmonella infection Pertussis Legionellosis Amoebiasis Tuberculosis Transcriptional misregulation in cancer Acute myeloid leukemia	ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade Transfer of LPS from LBP carrier to CD14 MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor TLR6:TLR2 Cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Neutrophil degranulation Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

Interactions

STRING	MINT	IntAct
ENSP00000304236	P08571	P08571

View interactions

Associated Diseases

Show/Hide all(17 )

Disease group	Disease Name	References
Blood Disorders
	Anemia	28039017, 20231419, 1616358
	Blood Coagulation Disorders	9790819
	Kawasaki disease	20921814, 15572393, 10632678
	Thrombocytopenia	22670776, 15725470
Cardiovascular Diseases
	Cardiovascular Abnormalities	20506307, 27915085, 16464548, 22898391, 28566450, 31398058, 31133024, 9675608, 23954259
	Atherosclerosis	27751505, 29133194, 30629987, 28344199, 29369549, 10199836, 26666179, 22999728, 30254012, 15116260
	Heart Failure	29463269, 26820481, 26981573, 23240665, 30240448, 26050484
	Coronary heart disease	29407600, 15367917, 27991581, 15269840, 24118494, 26123579, 16331574, 14517520, 22785372, 25668619, 22613847, 25463093
	Vascular Diseases	28634856, 18354240
	Aortic Valve Stenosis	28829829, 28097522
	Deep Vein Thrombosis	30088349
	Angina pectoris	25740391, 20684824, 25604313
	Myocardial Infarction	11810121, 24189501, 16698275, 22453004, 11257272, 14587643, 19795323, 10195920, 10385492, 23135962
	Aortic Aneurysm	23537804
	Acute Coronary Syndrome	24583418
	Limb Ischemia	29576595
	Atrial Fibrillation	26826137
	Hypertensive disease	18242048
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
	Keratoderma	17455194
	Biliary Atresia	21172039
Digestive System Diseases
	Disease of mouth	29702280
	Non-alcoholic Fatty Liver Disease	22188204
	Periodontitis	24001047, 19046305, 16246938, 23146639, 15120158, 14687231, 17309585, 17488439, 24461398, 12588460
	Pancreatitis	15599151, 28293095
	Hepatitis C	31357779
	Inflammatory Bowel Diseases	27795500, 18177452, 7590432, 15655821, 9353156, 25877931
	Colitis	27381199, 16085746, 19908144, 12126249
	Alcoholic fatty liver	16273620, 11343243, 23587862
	Liver Diseases	16046876, 18415752
	Intestinal Polyposis	23131784, 17499405
	Peritonitis	15730398
	Liver Failure	22837127, 28592438
	Liver Cirrhosis	20849360
Ear Or Mastoid Diseases
Ear Or Mastoid Diseases	Hearing Loss	25809471
Endocrine System Diseases
	PCOS	31184307
	Diabetes Mellitus	26581717, 23144172, 27377688, 25134759, 25082501, 29017104, 25887592
	Dwarfism	8565148
Eye Diseases
	Bullous keratopathy	11322422
	Diabetic Macular Edema	23095769
	Cataract	18557741
Immune System Diseases
	Allergic rhinitis	22846753, 29687183, 16950285, 26851967, 16076306, 17237444, 16109674, 19489918, 16290232, 14510721
	Autoimmune Diseases	20832340, 11407984, 24591168, 24327358
	AIDS	28754798
	HIV Infections	28133717, 27281059, 28397318, 7527738, 22804245, 22313961, 15937058, 12116363, 26181818, 19109192, 25622527
	Autoimmune Diabetes	25942429, 15611337
	Rheumatoid Arthritis	27045818, 27859685, 30511527, 26759164, 25333715, 16467036, 10219258, 9281388, 8639181, 21592822, 16320327, 24721042, 14762224, 25729037
	Hemophagocytic syndrome	31607329
	Graft-vs-Host Disease	26827181, 21913990, 19171766, 9057645
	Vasculitis	25766482
	Sarcoidosis	1280495, 7531099
	Thymic Hyperplasia	8688498
Musculoskeletal Diseases
	Spondylitis	29530480, 15647432
	Osteoarthritis	25544994
	Necrosis	12225363, 21323661, 10918046, 24997655, 1376258
	Bone Diseases	3070458, 2271774
	Spinal Tuberculosis	29298876
	Dental Caries	17451497
	Arthropathy	15034063
	Osteopetrosis	15231021
	Spondylarthritis	30755244
Neoplasms
	Leukemia	25852055, 29429058, 7525448, 1378160, 11673554, 10742386, 19864642, 20660791, 11807009, 21476947, 16552959
	Lung Cancer	30557823
	Ovarian Cancer	27354626, 24598451
	Lymphoma	16360418, 14576364, 19508433
	Multiple Sclerosis	27694998, 10556586
	Brain Tumor Polyposis	12835948
	Multiple Myeloma	28057743, 25798669
	Myeloid Leukemia	9855250, 9585076, 12358926, 1493908
	Gastric Cancer	24627605, 17086894
	Liver Cancer	10091598, 23960017
	Skin Cancer	25885805, 23633486, 24495013
	Colorectal Cancer	16706818
	Glioblastoma	20179016, 28551851
	Breast Cancer	21361908
	Prostate cancer	19902470, 28753790
	Bladder Cancer	30267200
Nervous System Diseases
	Huntington Disease	30228352, 11427632
	Systemic Lupus Erythematosus	16316784, 22482418, 25168844
	Cerebrovascular Disorders	11062291
	Stroke	19293821
	Demyelinating Diseases	28391986
	Muscular Dystrophy	21063901
	Brain Infarction	29310959
	Carotid Artery Diseases	27818999
Nutritional and Metabolic Diseases
	Metabolic Diseases	30476912
	Obesity	27677832, 25786686, 21799175
	Hyperhomocysteinemia	29439619
	Hyperglycemia	18180316
	Hyperlipemia	21930598
	Amyloidosis	11298127, 17187267
	Haemoglobinuria	7539547, 15272541
	Hyperuricaemia	23204548
	Hypovolemia	11753218
	Gluocose Intolerance	18448614
Psychiatric/Brain disorders
	Cognition Disorders	29196629
	Borderline Personality Disorder	28906511
	Schizophrenia and Rheumatoid Arthritis	16916546
	Pain Disorder	21303362, 16373680
Renal Disorder
Renal Disorder	Kidney Failure	8544403, 9596748, 11340249
Reproductive disorders
	Preeclampsia	17052752
	Endometriosis	30375700
Respiratory Tract Diseases
	Pulmonary Tuberculosis	20652908, 23741383, 17250589, 18008256, 23036271, 29937768
	Asthma	24376096, 18312481, 26463530, 17196641, 25966203, 10804928, 11732288, 16387800, 24902762, 20579716, 15602630, 11521081
	Pneumonia	18299306
	Lung Diseases	7686093, 17114449, 22267753
	Respiratory Distress Syndrome	17913858
Skin and Connective Tissue Diseases
	Eczema	19761511, 15867866, 19759553
	Leishmaniasis	30870579, 25802003
	Psoriasis	28673565
	Panniculitis	1479116
	Dermatitis	28460633

References

Show/Hide all(1)

PubMed ID	Associated gene/s	Associated condition	Genetic Mutation	Diagnostic Criteria	Association with PCOS	Ethnicity	Conclusion
31184307		PCOS, Inflammation		Rotterdam Criteria	Direct	38 PCOS patients and 40 controls (7 PCOS patients and 3 controls were downloaded from GEO dataset 34526)	In conclusion, our data collectively provide a comprehensive bioinformatics analysis of DEGs in PCOS. Our results confirm that the inflammation and immune play important roles in the occurrence and development of PCOS. Meanwhile, TLR signaling pathway mediating inflammation and immune might be involved in the pathogenesis of PCOS, and TLR2, TLR8, CD14 may be core target genes.