CD28: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

CD28

Aliases

Tp44

Entrez Gene ID

940

Gene Name

CD28 molecule

Chromosomal Location

2q33.2

HGNC ID

HGNC:1653

Summary

The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

RefSeq DNA

NG_029618.1

RefSeq mRNA

NM_006139.4, NM_001243077.2, NM_001243078.1

e!Ensembl

Gene	ENSG00000178562
Transcript	ENST00000458610, ENST00000324106, ENST00000374481
Protein	ENSP00000393648, ENSP00000324890, ENSP00000363605

Gene Ontology (GO)

Show/Hide all(34 )

GO ID	Ontology	Function	Evidence	Reference
GO:0002376	Biological process	Immune system process	IBA	21873635
GO:0006959	Biological process	Humoral immune response	TAS	8717514
GO:0007166	Biological process	Cell surface receptor signaling pathway	TAS	9784967
GO:0010628	Biological process	Positive regulation of gene expression	IMP	23817958
GO:0010629	Biological process	Negative regulation of gene expression	IMP	23817958
GO:0031295	Biological process	T cell costimulation	IBA	21873635
GO:0031295	Biological process	T cell costimulation	TAS	8617933
GO:0032733	Biological process	Positive regulation of interleukin-10 production	IDA	8617933
GO:0032753	Biological process	Positive regulation of interleukin-4 production	IDA	8617933
GO:0042089	Biological process	Cytokine biosynthetic process	TAS	8717514
GO:0042102	Biological process	Positive regulation of T cell proliferation	IBA	21873635
GO:0042102	Biological process	Positive regulation of T cell proliferation	IDA	3159820, 8617933
GO:0042102	Biological process	Positive regulation of T cell proliferation	TAS	9784967
GO:0042110	Biological process	T cell activation	IBA	21873635
GO:0042110	Biological process	T cell activation	IGI	18337562
GO:0043066	Biological process	Negative regulation of apoptotic process	TAS	8717514
GO:0045066	Biological process	Regulatory T cell differentiation	IDA	18641304
GO:0045070	Biological process	Positive regulation of viral genome replication	NAS	7492435
GO:0045086	Biological process	Positive regulation of interleukin-2 biosynthetic process	IBA	21873635
GO:0045086	Biological process	Positive regulation of interleukin-2 biosynthetic process	IDA	3875683
GO:0045727	Biological process	Positive regulation of translation	NAS	12028592
GO:0045840	Biological process	Positive regulation of mitotic nuclear division	IDA	3159820
GO:0050852	Biological process	T cell receptor signaling pathway	IBA	21873635
GO:0005886	Cellular component	Plasma membrane	IDA	11390434
GO:0005887	Cellular component	Integral component of plasma membrane	TAS	9784967
GO:0009897	Cellular component	External side of plasma membrane	IBA	21873635
GO:0009897	Cellular component	External side of plasma membrane	IDA	11390434
GO:0009986	Cellular component	Cell surface	IDA	15067037
GO:0098636	Cellular component	Protein complex involved in cell adhesion	IDA	7544393
GO:0002020	Molecular function	Protease binding	IPI	12777399
GO:0005070	Molecular function	SH3/SH2 adaptor activity	IDA	19641626
GO:0005515	Molecular function	Protein binding	IPI	7568038, 7584133, 7807015, 8146197, 8183372, 9417079, 9784967, 10820259, 11285224, 15067037, 15554700, 18641334
GO:0015026	Molecular function	Coreceptor activity	TAS	9784967
GO:0042802	Molecular function	Identical protein binding	NAS	3159820

Protein Information

Protein Name

T-cell-specific surface glycoprotein CD28, CD28 antigen

Function

Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037).

Refseq Proteins

NP_006130.1, NP_001230006.1, NP_001230007.1

UniProt

P10747

PDB

1YJD, 3WA4, 5AUL, 5GJH, 5GJI