CD40LG: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

CD40LG

Aliases

CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L

Entrez Gene ID

959

Gene Name

CD40 ligand

Chromosomal Location

Xq26.3

HGNC ID

HGNC:11935

Summary

The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_007280.1

RefSeq mRNA

NM_000074.3, NM_000074.2

e!Ensembl

Gene	ENSG00000102245
Transcript	ENST00000370629, ENST00000370628
Protein	ENSP00000359663, ENSP00000359662

Gene Ontology (GO)

Show/Hide all(19 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006954	Biological process	Inflammatory response	IDA	9468137
GO:0007159	Biological process	Leukocyte cell-cell adhesion	NAS	9468137
GO:0007257	Biological process	Activation of JUN kinase activity	IDA	15067037
GO:0030168	Biological process	Platelet activation	IDA	9468137
GO:0031295	Biological process	T cell costimulation	TAS	8617933
GO:0032733	Biological process	Positive regulation of interleukin-10 production	IDA	8617933
GO:0032735	Biological process	Positive regulation of interleukin-12 production	IDA	9922218
GO:0032753	Biological process	Positive regulation of interleukin-4 production	IDA	8617933
GO:0042100	Biological process	B cell proliferation	IDA	8605945
GO:0042102	Biological process	Positive regulation of T cell proliferation	IDA	8617933
GO:0043066	Biological process	Negative regulation of apoptotic process	IDA	12697681
GO:0051092	Biological process	Positive regulation of NF-kappaB transcription factor activity	IDA	15067037
GO:2000353	Biological process	Positive regulation of endothelial cell apoptotic process	IDA	12885753
GO:0005887	Cellular component	Integral component of plasma membrane	TAS	7678552
GO:0009986	Cellular component	Cell surface	IDA	15067037
GO:0016021	Cellular component	Integral component of membrane	NAS	9468137
GO:0005174	Molecular function	CD40 receptor binding	IBA	21873635
GO:0005174	Molecular function	CD40 receptor binding	IPI	9468137
GO:0005515	Molecular function	Protein binding	IPI	15067037

Protein Information

Protein Name

CD40 ligand, CD40 antigen ligand, CD40-L, T-B cell-activating molecule, T-cell antigen Gp39, TNF-related activation protein, tumor necrosis factor (ligand) superfamily member 5

Function

Cytokine that acts as a ligand to CD40/TNFRSF5 (PubMed:1280226, PubMed:31331973). Costimulates T-cell proliferation and cytokine production (PubMed:8617933). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B (PubMed:15067037, PubMed:31331973). Induces the activation of kinases MAPK8 and PAK2 in T-cells (PubMed:15067037). Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity). .; [CD40 ligand, soluble form]: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.

Refseq Proteins

NP_000065.1

UniProt

P29965

PDB

1ALY, 1I9R, 3LKJ, 3QD6, 6BRB

Pfam

Pfam Accession	Pfam ID
PF00229	TNF