CD74: Polycystic Ovarian Syndrome Database

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CD74

Gene Information

Gene Ontology (GO)

Protein Information

Associated Diseases

Pathways

References

Gene Information

Gene Symbol

CD74

Aliases

DHLAG, HLADG, II, Ia-GAMMA, p33

Entrez Gene ID

972

Gene Name

CD74 molecule

Chromosomal Location

5q33.1

HGNC ID

HGNC:1697

Summary

The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

RefSeq DNA

NG_029730.1

RefSeq mRNA

NM_001025159.2, NR_157074.2, NM_004355.3, NM_001025158.2, NM_001364083.2, NM_001364084.2

e!Ensembl

Gene	ENSG00000019582
Transcript	ENST00000009530, ENST00000377795, ENST00000353334, ENST00000518797, ENST00000524315, ENST00000523208, ENST00000522246, ENST00000523813
Protein	ENSP00000009530, ENSP00000367026, ENSP00000230685, ENSP00000430614, ENSP00000429024, ENSP00000430654, ENSP00000429641, ENSP00000429478

Gene Ontology (GO)

Show/Hide all(41 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001516	Biological process	Prostaglandin biosynthetic process	IDA	12782713
GO:0001934	Biological process	Positive regulation of protein phosphorylation	IDA	24942581
GO:0001961	Biological process	Positive regulation of cytokine-mediated signaling pathway	IMP	12782713
GO:0002792	Biological process	Negative regulation of peptide secretion	IDA	19849849
GO:0007165	Biological process	Signal transduction	IDA	12782713
GO:0008283	Biological process	Cell proliferation	IDA	12782713
GO:0019883	Biological process	Antigen processing and presentation of endogenous antigen	NAS	10981873
GO:0030890	Biological process	Positive regulation of B cell proliferation	IMP	12782713
GO:0033674	Biological process	Positive regulation of kinase activity	IDA	24942581
GO:0043030	Biological process	Regulation of macrophage activation	NAS	12782713
GO:0043066	Biological process	Negative regulation of apoptotic process	IDA	12782713
GO:0043123	Biological process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	IDA	24942581
GO:0043410	Biological process	Positive regulation of MAPK cascade	IDA	24942581
GO:0043518	Biological process	Negative regulation of DNA damage response, signal transduction by p53 class mediator	IDA	17045821
GO:0045058	Biological process	T cell selection	NAS	10981873
GO:0045657	Biological process	Positive regulation of monocyte differentiation	IDA	24942581
GO:0045893	Biological process	Positive regulation of transcription, DNA-templated	IDA	24942581
GO:0046598	Biological process	Positive regulation of viral entry into host cell	IDA	24942581
GO:0048146	Biological process	Positive regulation of fibroblast proliferation	IMP	12782713
GO:0050731	Biological process	Positive regulation of peptidyl-tyrosine phosphorylation	IDA	17045821
GO:0051290	Biological process	Protein heterotetramerization	IDA	24942581
GO:0070374	Biological process	Positive regulation of ERK1 and ERK2 cascade	IDA	17045821, 24942581
GO:0070374	Biological process	Positive regulation of ERK1 and ERK2 cascade	IMP	12782713
GO:1902166	Biological process	Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP	17045821
GO:0005773	Cellular component	Vacuole	IDA	19849849
GO:0009986	Cellular component	Cell surface	IDA	17045821
GO:0016020	Cellular component	Membrane	HDA	19946888
GO:0016021	Cellular component	Integral component of membrane	IDA	12782713
GO:0035692	Cellular component	Macrophage migration inhibitory factor receptor complex	IDA	17045821
GO:0070062	Cellular component	Extracellular exosome	HDA	20458337
GO:0001540	Molecular function	Amyloid-beta binding	IPI	19849849
GO:0004896	Molecular function	Cytokine receptor activity	IDA	17045821
GO:0005515	Molecular function	Protein binding	IPI	17357109, 19665027, 24428437, 29190904, 30833792
GO:0019955	Molecular function	Cytokine binding	IPI	12782713, 17567581
GO:0023026	Molecular function	MHC class II protein complex binding	IDA	1448172
GO:0035718	Molecular function	Macrophage migration inhibitory factor binding	IPI	17045821
GO:0042289	Molecular function	MHC class II protein binding	NAS	10981873
GO:0042609	Molecular function	CD4 receptor binding	IPI	24942581
GO:0042658	Molecular function	MHC class II protein binding, via antigen binding groove	IDA	7477400
GO:0042802	Molecular function	Identical protein binding	TAS	12782713
GO:0044183	Molecular function	Protein binding involved in protein folding	IDA	7477400

Protein Information

Protein Name

HLA class II histocompatibility antigen gamma chain, CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated), CD74 molecule, major histocompatibility complex, class II invariant chain, HLA-DR antigens-associated invariant chain, HLA-DR-gamma, Ia-associated invariant chain, MHC HLA-DR gamma chain, gamma chain of class II antigens

Function

Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF

Refseq Proteins

NP_001020330.1, , NP_004346.1, NP_001020329.1, NP_001351012.1, NP_001351013.1

UniProt

P04233

PDB

3PDO, 3PGC, 3PGD, 3QXA, 3QXD, 4AEN, 4AH2, 4X5W, 1A6A, 1ICF, 5KSU, 5KSV, 1IIE, 1L3H, 1MUJ

Pathways
	KEGG	Reactome
	Antigen processing and presentation Tuberculosis Herpes simplex virus 1 infection	Cell surface interactions at the vascular wall MHC class II antigen presentation

Interactions

STRING	MINT	IntAct
ENSP00000354255		Q66K79

View interactions

Associated Diseases

Show/Hide all(3 )

Disease group	Disease Name	References
Digestive System Diseases
Digestive System Diseases	Liver Failure	16799971
Endocrine System Diseases
Endocrine System Diseases	PCOS	26975253
Neoplasms
	Lung Cancer	22919003
	Breast Cancer	19602265

References

PMID: 26975253

Epigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary Syndrome.

Kokosar Milana, Benrick Anna, Perfilyev Alexander, Fornes Romina, Nilsson Emma, Maliqueo Manuel, Behre Carl Johan, Sazonova Antonina, Ohlsson Claes, Ling Charlotte, Stener-Victorin Elisabet

Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.| Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.| Epigenetics and Diabetes, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Clinical Research Centre, Malmo, Sweden.| Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.| Epigenetics and Diabetes, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Clinical Research Centre, Malmo, Sweden.| Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.| Endocrinology and Metabolism Laboratory, Department of Medicine, West division, University of Chile, Santiago, Chile.| The Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.| Department of Obstetrics and Gynecology, Reproductive Medicine, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.| Department of Internal Medicine, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.| Epigenetics and Diabetes, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Clinical Research Centre, Malmo, Sweden.| Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Sci Rep. 2016 Mar 15;6:22883. doi: 10.1038/srep22883.

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