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Gene Symbol |
CEBPB |
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Aliases |
C/EBP-beta, IL6DBP, NF-IL6, TCF5 |
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Entrez Gene ID |
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Gene Name |
CCAAT enhancer binding protein beta |
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Chromosomal Location |
20q13.13 |
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HGNC ID |
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Summary |
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013]
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RefSeq DNA |
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RefSeq mRNA |
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e!Ensembl
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Gene Ontology (GO)
| GO ID |
Ontology |
Function |
Evidence |
Reference |
| GO:0000122 |
Biological process |
Negative regulation of transcription by RNA polymerase II |
ISS |
15308669 |
| GO:0006355 |
Biological process |
Regulation of transcription, DNA-templated |
IDA |
20829347 |
| GO:0006366 |
Biological process |
Transcription by RNA polymerase II |
TAS |
10821850 |
| GO:0006953 |
Biological process |
Acute-phase response |
TAS |
2112087 |
| GO:0006954 |
Biological process |
Inflammatory response |
TAS |
2112087 |
| GO:0006955 |
Biological process |
Immune response |
TAS |
2112087 |
| GO:0034976 |
Biological process |
Response to endoplasmic reticulum stress |
IDA |
20829347 |
| GO:0045893 |
Biological process |
Positive regulation of transcription, DNA-templated |
IDA |
27812542 |
| GO:0045893 |
Biological process |
Positive regulation of transcription, DNA-templated |
IMP |
27812542 |
| GO:0045944 |
Biological process |
Positive regulation of transcription by RNA polymerase II |
IDA |
7959007 |
| GO:0070059 |
Biological process |
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
TAS |
14685163 |
| GO:0070169 |
Biological process |
Positive regulation of biomineral tissue development |
IDA |
27812542 |
| GO:0070169 |
Biological process |
Positive regulation of biomineral tissue development |
IMP |
27812542 |
| GO:0120162 |
Biological process |
Positive regulation of cold-induced thermogenesis |
ISS |
15762841 |
| GO:1901329 |
Biological process |
Regulation of odontoblast differentiation |
ISS |
15308669 |
| GO:1990440 |
Biological process |
Positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress |
IDA |
15775988 |
| GO:2000120 |
Biological process |
Positive regulation of sodium-dependent phosphate transport |
IDA |
27812542 |
| GO:2000120 |
Biological process |
Positive regulation of sodium-dependent phosphate transport |
IMP |
27812542 |
| GO:0005634 |
Cellular component |
Nucleus |
IDA |
20829347 |
| GO:0036488 |
Cellular component |
CHOP-C/EBP complex |
NAS |
15775988 |
| GO:0000977 |
Molecular function |
RNA polymerase II regulatory region sequence-specific DNA binding |
IDA |
7959007 |
| GO:0000981 |
Molecular function |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ISM |
19274049 |
| GO:0000981 |
Molecular function |
DNA-binding transcription factor activity, RNA polymerase II-specific |
NAS |
19274049 |
| GO:0001227 |
Molecular function |
DNA-binding transcription repressor activity, RNA polymerase II-specific |
ISS |
15308669 |
| GO:0003677 |
Molecular function |
DNA binding |
TAS |
10821850 |
| GO:0003700 |
Molecular function |
DNA-binding transcription factor activity |
NAS |
10821850 |
| GO:0005515 |
Molecular function |
Protein binding |
IPI |
12692227, 16227626, 17724128, 20102225, 20111005, 20829347, 24043631 |
| GO:0046982 |
Molecular function |
Protein heterodimerization activity |
NAS |
15775988 |
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| Protein Information |
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Protein Name |
CCAAT/enhancer-binding protein beta, CCAAT/enhancer binding protein (C/EBP), beta, interleukin 6-dependent DNA-binding protein, nuclear factor NF-IL6, nuclear factor of interleukin 6, transcription factor 5, transcription factor C/EBP beta |
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Function |
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UniProt |
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PDB |
1GTW, 1GU4, 1GU5, 1H88, 1H89, 1H8A, 1HJB, 1IO4, 2E42, 2E43, 6MG1, 6MG2, 6MG3 |
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Pfam |
| Pfam Accession |
Pfam ID |
| PF07716 |
bZIP_2 |
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Interactions |
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| STRING |
MINT |
IntAct |
| ENSP00000303939 |
P16410 |
P16410 |
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View interactions
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Associated Diseases
| Disease group | Disease Name | References |
| Digestive System Diseases |
| Fatty Liver |
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| Endocrine System Diseases |
| PCOS |
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| Neoplasms |
| Liver Cancer |
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| Nervous System Diseases |
| Cerebral Ischemia |
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| Reproductive disorders |
| Subfertility, Female |
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| Respiratory Tract Diseases |
| Pulmonary Fibrosis |
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References |
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| Shen Hao-Ran, Qiu Li-Hua, Zhang Zhi-Qing, Qin Yuan-Yuan, Cao Cong, Di Wen |
| Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. |
| PLoS One. 2013 May 21;8(5):e64801. doi: 10.1371/journal.pone.0064801. Print 2013. |
Abstract
Polycystic ovary syndrome (PCOS) is a complex, heterogeneous disorder of uncertain etiology. Recent studies suggested that insulin resistance (IR) plays an important role in the development of PCOS. In the current study, we aimed to investigate the molecular mechanism of IR in PCOS. We employed genome-wide methylated DNA immunoprecipitation (MeDIP) analysis to characterize genes that are differentially methylated in PCOS patients vs. healthy controls. Besides, we also identified the differentially methylated genes between patients with PCOS-non-insulin resistance (PCOS-NIR) and PCOS-insulin resistance (PCOS-IR). A total of 79 genes were differentially methylated between PCOS-NIR vs. PCOS-IR patients, and 40 genes were differentially methylated in PCOS patients vs. healthy controls. We analyzed these differentially methylated genes by constructing regulatory networks and protein-protein interaction (PPI) networks. Further, Gene Ontology (GO) and pathway enrichment analysis were also performed to investigate the biological functions of networks. We identified multiple categories of genes that were differentially methylated between PCOS-NIR and PCOS-IR patients, or between PCOS patients and healthy controls. Significantly, GO categories of immune response were differentially methylated in PCOS-IR vs. PCOS-NIR. Further, genes in cancer pathways were also differentially methylated in PCOS-NIR vs. PCOS-IR patients or in PCOS patients vs. healthy controls. The results of this current study will help to further understand the mechanism of PCOS. |
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| © 2019, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
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