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Gene Symbol |
CFL1 |
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Aliases |
CFL, HEL-S-15, cofilin |
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Entrez Gene ID |
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Gene Name |
Cofilin 1 |
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Chromosomal Location |
11q13.1 |
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HGNC ID |
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Summary |
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]
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e!Ensembl
| Gene |
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| Transcript |
ENST00000525451, ENST00000527344, ENST00000531407, ENST00000524553, ENST00000534769, ENST00000531413, ENST00000532134, ENST00000530413, ENST00000534784, ENST00000526975, ENST00000308162 |
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| Protein |
ENSP00000432660, ENSP00000432155, ENSP00000433910, ENSP00000432226, ENSP00000431696, ENSP00000433131, ENSP00000436431, ENSP00000436899, ENSP00000433308, ENSP00000432153, ENSP00000309629
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Gene Ontology (GO)
| GO ID |
Ontology |
Function |
Evidence |
Reference |
| GO:0007010 |
Biological process |
Cytoskeleton organization |
IMP |
21834987 |
| GO:0007266 |
Biological process |
Rho protein signal transduction |
TAS |
10436159 |
| GO:0009615 |
Biological process |
Response to virus |
IEP |
16548883 |
| GO:0022604 |
Biological process |
Regulation of cell morphogenesis |
IMP |
21834987 |
| GO:0030036 |
Biological process |
Actin cytoskeleton organization |
TAS |
10436159 |
| GO:0030042 |
Biological process |
Actin filament depolymerization |
IDA |
11812157 |
| GO:0030042 |
Biological process |
Actin filament depolymerization |
NAS |
24052308 |
| GO:0043066 |
Biological process |
Negative regulation of apoptotic process |
TAS |
16130169 |
| GO:0044794 |
Biological process |
Positive regulation by host of viral process |
IMP |
25556234 |
| GO:0061001 |
Biological process |
Regulation of dendritic spine morphogenesis |
IMP |
24464040 |
| GO:0005615 |
Cellular component |
Extracellular space |
HDA |
23580065 |
| GO:0005634 |
Cellular component |
Nucleus |
TAS |
16130169 |
| GO:0005737 |
Cellular component |
Cytoplasm |
IDA |
25556234 |
| GO:0005737 |
Cellular component |
Cytoplasm |
TAS |
16130169 |
| GO:0005925 |
Cellular component |
Focal adhesion |
HDA |
21423176 |
| GO:0005925 |
Cellular component |
Focal adhesion |
IDA |
29162887 |
| GO:0016020 |
Cellular component |
Membrane |
HDA |
19946888 |
| GO:0031982 |
Cellular component |
Vesicle |
HDA |
19190083 |
| GO:0070062 |
Cellular component |
Extracellular exosome |
HDA |
19199708, 20458337, 23533145 |
| GO:0005515 |
Molecular function |
Protein binding |
IPI |
12361576, 15161933, 15846844, 16189514, 16713569, 17853892, 19424295, 20133759, 21525957, 25416956, 25556234 |
| GO:0051015 |
Molecular function |
Actin filament binding |
IDA |
11812157 |
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| Protein Information |
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Protein Name |
Cofilin-1, 18 kDa phosphoprotein, cofilin 1 (non-muscle), cofilin, non-muscle isoform, epididymis secretory protein Li 15, p18 |
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Function |
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Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:11812157, PubMed:15580268, PubMed:21834987, PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity). |
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UniProt |
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PDB |
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Pfam |
| Pfam Accession |
Pfam ID |
| PF00241 |
Cofilin_ADF |
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Interactions |
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| STRING |
MINT |
IntAct |
| ENSP00000305651 |
P02778 |
P02778 |
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View interactions
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Associated Diseases
| Disease group | Disease Name | References |
| Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| Status Dysraphicus |
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| Endocrine System Diseases |
| PCOS |
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| Neoplasms |
| Breast Cancer |
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| Esophagus Neoplasm |
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| Nervous System Diseases |
| Spina Bifida |
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References |
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| Atiomo W, Khalid S, Parameshweran S, Houda M, Layfield R |
| Department of Obstetrics and Gynaecology, School of Human Development, University of Nottingham, and Nottingham University Hospitals, Nottingham, UK. william.atiomo@nottingham.ac.uk |
| BJOG. 2009 Jan;116(2):137-43. doi: 10.1111/j.1471-0528.2008.02041.x. |
Abstract
BACKGROUND: The exact causes of polycystic ovary syndrome (PCOS) are uncertain, and treatment could be improved. Discovery-based approaches like 'proteomics' may result in faster insights into the causes of PCOS and improved treatment. OBJECTIVES: To identify the number and nature of proteomic biomarkers found in PCOS so far and to identify their diagnostic and therapeutic potential. SEARCH STRATEGY: All published studies on proteomic biomarkers in women with PCOS identified through the MEDLINE (1966-2008), EMBASE (1980-2008) and the ISI web of knowledge (v4.2) databases. SELECTION CRITERIA: The terms 'polycystic ovary syndrome' and 'proteomic', 'proteomics', 'proteomic biomarker' or 'proteomics biomarker' without any limits/restrictions were used. DATA COLLECTION AND ANALYSIS: Original data were abstracted where available and summarised on a separate Microsoft Excel (2007) database for analysis. MAIN RESULTS: Seventeen articles were identified, of which 6 original papers and 1 review article contained original data. Tissues investigated included serum, omental biopsies, ovarian biopsies, follicular fluid and T lymphocytes. Sample sizes ranged from 3 to 30 women. One hundred and forty-eight biomarkers were identified. The biomarkers were involved in many pathways, for example the regulation of fibrinolysis and thrombosis, insulin resistance, immunity/inflammation and the antioxidant pathway. Eleven groups of biomarkers appeared to be independently validated. The individual sensitivities for the diagnosis of PCOS were reported for 11 named biomarkers and ranged from 57 to 100%. AUTHOR'S CONCLUSIONS: Proteomic biomarker discovery in PCOS offers great potential. Current challenges include reproducibility and data analysis. The establishment of a PCOS-specific biomarker data bank and international consensus on the framework of systematic reviews in this field are required. |
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National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
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