CGB5: Polycystic Ovarian Syndrome Database

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CGB5

Gene Information

Gene Ontology (GO)

Protein Information

Associated Diseases

Pathways

References

Gene Information

Gene Symbol

CGB5

Aliases

CGB, HCG, hCGB

Entrez Gene ID

93659

Gene Name

Chorionic gonadotropin subunit beta 5

Chromosomal Location

19q13.33

HGNC ID

HGNC:16452

Summary

This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 5 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]

e!Ensembl

Gene	ENSG00000189052
Transcript	ENST00000301408
Protein	ENSP00000301408

Protein Information

Protein Name

Chorionic gonadotropin, beta polypeptide 5, chorionic gonadotropin beta 5 subunit, chorionic gonadotropin beta subunit 5

Function

PDB

1HCN, 1HRP, 1QFW, 1XUL

Pathways
	Reactome
		Glycoprotein hormones TFAP2 (AP-2) family regulates transcription of growth factors and their receptors

Interactions

STRING	MINT	IntAct
ENSP00000458162	P63261	P63261

View interactions

Associated Diseases

Show/Hide all(3 )

Disease group	Disease Name	References
Endocrine System Diseases
Endocrine System Diseases	PCOS	19240152
Neoplasms
Neoplasms	Ovarian Cancer	21411543
Reproductive disorders
Reproductive disorders	Preeclampsia	20541258

References

Show/Hide all(1)

PubMed ID	Associated gene/s	Associated condition	Genetic Mutation	Diagnostic Criteria	Association with PCOS	Ethnicity	Conclusion
19240152	FSH	PCOS, oligoamenorrheic, hyperandrogenemic		NIH criteria	Related	30 typical PCOS cohort, 14 atypical PCOS cohort, 14 Controls (non hispanic whites and blacks)	Typical PCOS is characterized by intrinsic ovarian hypersensitivity to hCG to which excessive paracrine FSH signaling via inhibin-B may contribute. Atypical PCOS is due to a unique type of ovarian dysfunction that is relatively gonadotropin hyposensitive.