CHI3L1: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

CHI3L1

Aliases

ASRT7, CGP-39, GP-39, GP39, HC-gp39, HCGP-3P, YK-40, YKL-40, YKL40, YYL-40, hCGP-39

Entrez Gene ID

1116

Gene Name

Chitinase 3 like 1

Chromosomal Location

1q32.1

HGNC ID

HGNC:1932

Summary

Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009]

RefSeq DNA

NG_013056.1

RefSeq mRNA

NM_001276.2, NM_001276.4

e!Ensembl

Gene	ENSG00000133048
Transcript	ENST00000255409, ENST00000404436
Protein	ENSP00000255409, ENSP00000385350

Gene Ontology (GO)

Show/Hide all(20 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006954	Biological process	Inflammatory response	IEP	16234240
GO:0009612	Biological process	Response to mechanical stimulus	IEP	20650887
GO:0030324	Biological process	Lung development	IMP	18403759
GO:0034612	Biological process	Response to tumor necrosis factor	IEP	16234240
GO:0045766	Biological process	Positive regulation of angiogenesis	IMP	21385870
GO:0051216	Biological process	Cartilage development	NAS	8245017
GO:0051897	Biological process	Positive regulation of protein kinase B signaling	IMP	21385870
GO:0070374	Biological process	Positive regulation of ERK1 and ERK2 cascade	IMP	21385870
GO:0070555	Biological process	Response to interleukin-1	IEP	16234240
GO:0070741	Biological process	Response to interleukin-6	IEP	21478032
GO:0005576	Cellular component	Extracellular region	IBA	21873635
GO:0005615	Cellular component	Extracellular space	HDA	16502470
GO:0005615	Cellular component	Extracellular space	IDA	8245017, 9492324
GO:0031012	Cellular component	Extracellular matrix	NAS	8245017
GO:0070062	Cellular component	Extracellular exosome	HDA	23533145
GO:0004568	Molecular function	Chitinase activity	IDA	8245017, 9492324
GO:0005201	Molecular function	Extracellular matrix structural constituent	NAS	8245017
GO:0005515	Molecular function	Protein binding	IPI	27629921, 28143526, 29427412
GO:0008061	Molecular function	Chitin binding	IBA	21873635
GO:0008061	Molecular function	Chitin binding	IDA	9492324, 12775711

Protein Information

Protein Name

Chitinase-3-like protein 1, 39 kDa synovial protein, cartilage glycoprotein 39, chitinase 3-like 1 (cartilage glycoprotein-39)

Function

Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.

Refseq Proteins

NP_001267.2

UniProt

P36222

PDB

1HJV, 1HJW, 1HJX, 1LA7, 1NWR, 1NWS, 1NWT, 1NWU

Pfam

Pfam Accession	Pfam ID
PF00704	Glyco_hydro_18