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Gene Symbol |
CRP |
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Aliases |
PTX1 |
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Entrez Gene ID |
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Gene Name |
C-reactive protein |
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Chromosomal Location |
1q23.2 |
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HGNC ID |
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Summary |
The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]
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RefSeq DNA |
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RefSeq mRNA |
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e!Ensembl
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| Protein Information |
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Protein Name |
C-reactive protein, C-reactive protein, pentraxin-related, pentraxin 1 |
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Function |
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Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells |
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UniProt |
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PDB |
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Pfam |
| Pfam Accession |
Pfam ID |
| PF00354 |
Pentaxin |
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Interactions |
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| STRING |
MINT |
IntAct |
| ENSP00000379472 |
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P06307 |
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View interactions
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Associated Diseases
| Disease group | Disease Name | References |
| Cardiovascular Diseases |
| Arteriosclerosis |
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| Carditis |
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| Myocarditis |
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| Heart Failure |
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| Acute Coronary Syndrome |
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| Hypertensive disease |
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| Myocardial Failure |
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| Myocardial Ischemia |
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| Atherosclerosis |
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| Heart Diseases |
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| Digestive System Diseases |
| Periodontitis |
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| Colitis |
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| Crohn Disease |
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| Enteritis |
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| Endocrine System Diseases |
| Ketosis-prone diabetes |
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| Hyperparathyroidism |
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| Brittle diabetes |
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| Diabetes Mellitus |
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| PCOS |
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| Eye Diseases |
| Diabetic Retinopathy |
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| Immune System Diseases |
| Autoimmune Diabetes |
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| Lupus Erythematosus |
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| Libman-Sacks Disease |
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| Rheumatoid Arthritis |
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| Neoplasms |
| Lung Cancer |
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| Liver Cancer |
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| Nervous System Diseases |
| Arsenic Encephalopathy |
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| Meningitis |
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| Nutritional and Metabolic Diseases |
| Metabolic Diseases |
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| Metabolic Syndrome X |
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| Obesity |
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| Gluocose Intolerance |
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| Psychiatric/Brain disorders |
| Anxiety Disorders |
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| Mental Depression |
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| Schizophrenia |
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| Obstructive Sleep Apnea |
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| Renal Disorder |
| Nephritis, Interstitial |
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| Kidney Failure |
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| Reproductive disorders |
| Preeclampsia |
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| Skin and Connective Tissue Diseases |
| Psoriasis |
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| Pustulosis |
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| Leishmaniasis |
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References |
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| PubMed ID |
Associated gene/s |
Associated condition |
Genetic Mutation |
Diagnostic Criteria |
Association with PCOS |
Ethnicity |
Conclusion |
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cardiovascular risk |
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Rotterdam criteria |
Related
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30 PCOS, 30 PCO and 30 controls |
women with PCO have higher serum CRP levels than healthy control women. This may contribute to increased cardiovascular disease risk in patients with PCO |
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BMI, PCOS |
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Related
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40 PCOS and 30 controls |
In patients with PCOS, serum CRP levels were higher than age and BMI-matched controls |
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MCP-1 |
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Related
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85 PCOS and 65 Control |
Patients with PCOS suffer low-grade chronic inflammation indicated by higher levels of CRP and MCP-1, which could lead to increased risk of atherogenesis |
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PTX3 |
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Related
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40 PCOS and 40 controls |
PTX3 level is increased in patients with PCOS in concordance with insulin resistance. |
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PEDF |
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Related
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96 PCOS and 63controls |
The serum PEDF levels are closely associated with hs-CRP in women with PCOS. PEDF may play a role in the development of chronic inflammation in PCOS |
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UrotensinII |
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Related
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47 PCOS and 42 Control |
positive correlation was found between with UII and hs-CRP(r = 0.51, p < 0.001). Our study data suggested that UII may have a role in the pathophysiology of insulin resistance and increased cardiovascular risk, which are commonly found in patients with PCOS |
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sCD40L |
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Related
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44 PCOS and 39 Control |
observed inter-relationships suggest that CRP in collaboration with the CD40-CD40L system may have a role in the pathogenesis of PCOS |
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NIH criteria |
Related
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81 families comprised of PCOS patients and their first-degree relatives for 305 subjects. |
We observed elevated CRP levels in 94% of the offspring in group C, 45% in group B and 10% in group A after adjusting for age, gender and BMI of the offspring. The median BMI of the offspring in group A, B and C were 30.0, 28.7 and 31.2 kg/m2, respectively. Heritability estimates of CRP levels ranged from 0.75 to 0.83 and remained significant after excluding for type 2 diabetes mellitus. Our small sample size increases the possibility of a type 1 error. |
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IL-6 and IL-1 |
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Related
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20 PCO and 20 control |
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CIMT and OGTT |
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Related
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34 PCOS and 20 Control |
Both of CIMT and CRP levels were significantly higher in the PCOS patients had BMI over 25 kg/m . CRP levels was significantly higher in the PCOS patients had waist circumference greater than 80 cm |
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Related
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70 PCOS and 70 Control |
Low-grade inflammation occurs in PCOS. Increased hsCRP and cytokines are associated with IR, but increased WCC is observed even when IR is accounted for |
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NT-proBNP |
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Related
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25 PCOS and 25 Control |
levels of BNP, CRP and homocystein were not different in PCOS subjects |
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C3 |
Insulin Resistance |
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Related
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133 PCOS and 116 Control |
Compared with hs-CRP, serum C3 might be a stronger inflammatory marker of IR in women with PCOS |
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Rotterdam criteria |
Related
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Women with PCOS exhibit an elevation in circulating CRP that is independent of obesity |
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Related
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91 PCOS and 51 control |
The presence of PCOS, independent from obesity and IR, is the strongest predictor of elevated hs-CRP level |
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vaspin |
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Related
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24 PCOS and 24 control |
presence of the increased vaspin, CRP and higher HOMA-IR levels in women with PCOSand PCO could contribute to increased diabetogenic and atherogenic risk in these patients |
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Insulin Resistance |
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Related
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50 PCOS and 36 with idiopathic hyperandrogenism |
PCOS is accompanied by a low-grade chronic inflammation. Body fat appears the main determining factor of this finding, which is only partly explained by insulin resistance |
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Hcy |
Heart Rate Recovery |
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Rotterdam criteria |
Related
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68 PCOS and 68 Control |
The CRP and Hcy levels may affect the development and progression of abnormal HRR in PCOS |
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Rotterdam criteria |
Related
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74 PCOS and 51 Control |
The data showed that chronic nonspecific inflammation exists among Chinese patients with PCOS and that this kind of inflammation was related to insulin resistance, BMI, and triglycerides |
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Related
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124 PCOS |
Acute-phase reactants, such as CRP and fibrinogen, and WBCs count were independently and inversely associated with a direct measure of cardiorespiratory fitness (VO(2 max)) in women with PCOS, even after adjustment for physical activity level and other potential confounding factors |
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ASP and ASP precursor |
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Rotterdam criteria |
Related
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34 PCOS and 41 Control |
Levels of ASP, CRP, and lipids are increased in subjects with PCOS, regardless of the level of BMI. The increased ASP level in both PCOS groups suggests that the ASP metabolism may be altered |
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Related
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44 PCOS and 26 Control |
In PCOS women, plasma levels of Hcy and CRP were significantly elevated compared with age- and BMI-matched controls. Although most of the PCOS-related endocrine and metabolic changes are related to elevated plasma Hcy and CRP levels in PCOS women, BMI seems to be the major factor determining CHD and T2DM in women with PCOS |
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Related
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15 PCOS and 17 Control |
A 4-5% weight loss improved lipid, glucose, and insulin profiles in women with and without PCOS. This degree of weight loss was not effective in lowering CRP concentrations in PCOS women, suggesting that greater weight loss is required in this group to achieve equivalent cardiovascular benefit to non-PCOS women. |
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carotid intima-media wall thickness (IMT) |
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The clinical diagnosis of PCOS was made if there was a history of chronic anovulation in association with either 1) clinical evidence of androgen excess (hirsutism) or biochemical evidence of an elevated total testosterone concentration (>57.64 ng/dl; 2 n |
Related
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47 PCOS and 59 controls |
Obesity partially explained the influence of PCOS and CRP on IMT. The effect of body mass index on the PCOS-IMT relationship was not completely determined by hyperinsulinemia or visceral fat, and might be mediated by other aspects of PCOS-related adiposity |
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PCOS was defined as androgen excess (total testosterone >3.6 nmol/L or a free androgen index 9) with ovulatory dysfunction (less than six menstrual cycles per yr) once specific disorders, such as adult-onset congenital adrenal hyperplasia, hyperprolactin |
Related
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17 PCOS and 15 Control |
PCOS have significantly increased CRP concentrations relative to women with normal menstrual rhythm and normal androgen levels. We propose low grade chronic inflammation as a novel mechanism contributing to increased risk of CHD and type 2 diabetes in these women |
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