CTF1: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

CTF1

Aliases

CT-1, CT1

Entrez Gene ID

1489

Gene Name

Cardiotrophin 1

Chromosomal Location

16p11.2

HGNC ID

HGNC:2499

Summary

The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

RefSeq DNA

NG_009171.1

RefSeq mRNA

NM_001142544.2, NM_001330.3

e!Ensembl

Gene	ENSG00000150281
Transcript	ENST00000279804, ENST00000395019
Protein	ENSP00000279804, ENSP00000378465

Gene Ontology (GO)

Show/Hide all(9 )

GO ID	Ontology	Function	Evidence	Reference
GO:0007166	Biological process	Cell surface receptor signaling pathway	IBA	21873635
GO:0007267	Biological process	Cell-cell signaling	TAS	7862649
GO:0007517	Biological process	Muscle organ development	TAS	7862649, 8833032
GO:0008284	Biological process	Positive regulation of cell proliferation	TAS	7862649
GO:0030182	Biological process	Neuron differentiation	TAS	7738033
GO:0042531	Biological process	Positive regulation of tyrosine phosphorylation of STAT protein	IDA	21912637
GO:0005576	Cellular component	Extracellular region	IBA	21873635
GO:0005125	Molecular function	Cytokine activity	IBA	21873635
GO:0005515	Molecular function	Protein binding	IPI	25416956

Protein Information

Protein Name

Cardiotrophin-1, cardiophin 1

Function

Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor

Refseq Proteins

NP_001136016.1, NP_001321.1

UniProt

Q16619