CXCL10: Polycystic Ovarian Syndrome Database

Home

Search
- Quick Search
- Advanced Search

Browse
- Genes
- miRNAs
- SNPs
- Diseases
  - Genes
  - miRNAs
- Pathways
- Ontologies

Tools

Help

CXCL10

Gene Information

Gene Ontology (GO)

Protein Information

Associated Diseases

Pathways

References

Gene Information

Gene Symbol

CXCL10

Aliases

C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1

Entrez Gene ID

3627

Gene Name

C-X-C motif chemokine ligand 10

Chromosomal Location

4q21.1

HGNC ID

HGNC:10637

Summary

This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014]

e!Ensembl

Gene	ENSG00000169245
Transcript	ENST00000306602
Protein	ENSP00000305651

Gene Ontology (GO)

Show/Hide all(38 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006935	Biological process	Chemotaxis	IDA	12782716
GO:0006954	Biological process	Inflammatory response	IBA	21873635
GO:0006955	Biological process	Immune response	IBA	21873635
GO:0007165	Biological process	Signal transduction	TAS	10201891
GO:0007166	Biological process	Cell surface receptor signaling pathway	TAS	10903763
GO:0007186	Biological process	G protein-coupled receptor signaling pathway	IMP	12782716
GO:0007189	Biological process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	12782716
GO:0007267	Biological process	Cell-cell signaling	TAS	3925348
GO:0007517	Biological process	Muscle organ development	TAS	8798675
GO:0008015	Biological process	Blood circulation	TAS	8798675
GO:0010818	Biological process	T cell chemotaxis	IMP	18645041
GO:0010819	Biological process	Regulation of T cell chemotaxis	IDA	8608232
GO:0016525	Biological process	Negative regulation of angiogenesis	IDA	7540647
GO:0030593	Biological process	Neutrophil chemotaxis	IBA	21873635
GO:0030595	Biological process	Leukocyte chemotaxis	IBA	21873635
GO:0042118	Biological process	Endothelial cell activation	IGI	19470579
GO:0042127	Biological process	Regulation of cell proliferation	IDA	12782716
GO:0042981	Biological process	Regulation of apoptotic process	IDA	22652417
GO:0045944	Biological process	Positive regulation of transcription by RNA polymerase II	TAS	12782716
GO:0051281	Biological process	Positive regulation of release of sequestered calcium ion into cytosol	IDA	12782716
GO:0061844	Biological process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IBA	21873635
GO:0070098	Biological process	Chemokine-mediated signaling pathway	IBA	21873635
GO:0070098	Biological process	Chemokine-mediated signaling pathway	IMP	18645041
GO:0071222	Biological process	Cellular response to lipopolysaccharide	IBA	21873635
GO:0071222	Biological process	Cellular response to lipopolysaccharide	IMP	23776175
GO:0090026	Biological process	Positive regulation of monocyte chemotaxis	IDA	8608232
GO:1901509	Biological process	Regulation of endothelial tube morphogenesis	IDA	16484616
GO:2000406	Biological process	Positive regulation of T cell migration	IDA	23620790
GO:0005576	Cellular component	Extracellular region	IDA	20041150
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0005102	Molecular function	Signaling receptor binding	TAS	10201891
GO:0005515	Molecular function	Protein binding	IPI	18275857, 21314817, 28381538
GO:0008009	Molecular function	Chemokine activity	IBA	21873635
GO:0008009	Molecular function	Chemokine activity	IDA	12782716
GO:0008201	Molecular function	Heparin binding	IMP	18645041
GO:0008603	Molecular function	CAMP-dependent protein kinase regulator activity	TAS	10903763
GO:0042056	Molecular function	Chemoattractant activity	IDA	11157474
GO:0048248	Molecular function	CXCR3 chemokine receptor binding	IDA	12782716

Protein Information

Protein Name

C-X-C motif chemokine 10, 10 kDa interferon gamma-induced protein, chemokine (C-X-C motif) ligand 10, gamma IP10, interferon-inducible cytokine IP-10, protein 10 from interferon (gamma)-induced cell line, small inducible cytokine subfamily B (Cys-X-Cys), member 10, small-inducible cytokine B10

Function

Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (PubMed:7540647, PubMed:11157474, PubMed:22652417). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization (PubMed:12750173, PubMed:19151743). In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (PubMed:12750173, PubMed:12663757). Activation of the CXCL10/CXCR3 axis plays also an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity).

UniProt

P02778

PDB

1LV9, 1O7Y, 1O7Z, 1O80

Pfam

Pfam Accession	Pfam ID
PF00048	IL8

Pathways
	KEGG	Reactome
	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway Toll-like receptor signaling pathway RIG-I-like receptor signaling pathway Cytosolic DNA-sensing pathway IL-17 signaling pathway TNF signaling pathway Hepatitis C Influenza A Epstein-Barr virus infection	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling

Interactions

STRING	MINT	IntAct
ENSP00000286692		Q6UX65

View interactions

Associated Diseases

Show/Hide all(10 )

Disease group	Disease Name	References
Cardiovascular Diseases
Cardiovascular Diseases	Myocardial Ischemia	16214533
Digestive System Diseases
	Biliary Cirrhosis	18422935
	Liver Diseases	11739529
	Hepatitis	11739529
Ear Or Mastoid Diseases
Ear Or Mastoid Diseases	Meniere Disease	28787010
Endocrine System Diseases
Endocrine System Diseases	PCOS	28051885
Neoplasms
	Thyroid Cancer	26037280
	Colonic Neoplasms	15059925
Nervous System Diseases
Nervous System Diseases	Cerebral Ischemia	15829914
Psychiatric/Brain disorders
	Mental Depression	18504423
	Obstructive Sleep Apnea	25656804
Renal Disorder
	Painful Bladder Syndrome	18957084
	Interstitial Cystitis	18957084
Respiratory Tract Diseases
Respiratory Tract Diseases	Influenza	23326326
Skin and Connective Tissue Diseases
	Alopecia Areata	22358057
	Eczema	18249437
	Dermatitis	18249437

References

PMID: 28051885

Elevated serum interferon gamma-inducible protein-10 in women with polycystic ovary syndrome.

Deng Hongli, Li Zhibo, Liu Guang, Li Xianhua, Chen Yong, Zhang Yong, Sun Yifan, Fu Jinjian

a Department of Clinical Laboratory , Affiliated Liuyang Hospital of University of South China, People's Hospital of Liuyang City , Changsha , Hunan , China.| a Department of Clinical Laboratory , Affiliated Liuyang Hospital of University of South China, People's Hospital of Liuyang City , Changsha , Hunan , China.| a Department of Clinical Laboratory , Affiliated Liuyang Hospital of University of South China, People's Hospital of Liuyang City , Changsha , Hunan , China.| a Department of Clinical Laboratory , Affiliated Liuyang Hospital of University of South China, People's Hospital of Liuyang City , Changsha , Hunan , China.| b Department of Clinical Laboratory , Affiliated Changsha Hospital of University of South China, The First Hospital of Changsha City , Changsha , Hunan , China.| c Department of Gastrointestinal Surgery , Affiliated Liuyang Hospital of University of South China, People's Hospital of Liuyang City , Chang sha , Hunan , China.| d Department of Clinical Laboratory , Third Af fi liated Hospital of Guangxi University of Chinese Medicine , Liuzhou , Guangxi , China , and.| e Department of Clinical Laboratory , Liuzhou Maternity and Child Health Care Hospital , Liuzhou , Guangxi , China.

Gynecol Endocrinol. 2017 May;33(5):363-367. doi: 10.1080/09513590.2016.1269740.

Statistics

About BIC

Feedback

Links

Contact Us

| © 2019, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
Tel: 91-22-24192104, Fax No: 91-22-24139412