CXCL8: Polycystic Ovarian Syndrome Database

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CXCL8

Gene Information

Gene Ontology (GO)

Protein Information

Associated Diseases

Pathways

References

Gene Information

Gene Symbol

CXCL8

Aliases

GCP-1, GCP1, IL8, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1

Entrez Gene ID

3576

Gene Name

C-X-C motif chemokine ligand 8

Chromosomal Location

4q13.3

HGNC ID

HGNC:6025

Summary

The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is secreted primarily by neutrophils, where it serves as a chemotactic factor by guiding the neutrophils to the site of infection. This chemokine is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, Aug 2017]

RefSeq DNA

NG_029889.1

RefSeq mRNA

NM_000584.4, NM_001354840.2

e!Ensembl

Gene	ENSG00000169429
Transcript	ENST00000307407, ENST00000401931
Protein	ENSP00000306512, ENSP00000385908

Gene Ontology (GO)

Show/Hide all(40 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001525	Biological process	Angiogenesis	TAS	11483765
GO:0002237	Biological process	Response to molecule of bacterial origin	IDA	19912257
GO:0006935	Biological process	Chemotaxis	TAS	12782716
GO:0006954	Biological process	Inflammatory response	IBA	21873635
GO:0006954	Biological process	Inflammatory response	TAS	11483765
GO:0006955	Biological process	Immune response	IBA	21873635
GO:0007050	Biological process	Cell cycle arrest	IDA	11564821
GO:0007165	Biological process	Signal transduction	TAS	10820279
GO:0008285	Biological process	Negative regulation of cell proliferation	TAS	9551928
GO:0019722	Biological process	Calcium-mediated signaling	TAS	11877327
GO:0030155	Biological process	Regulation of cell adhesion	IDA	2007144
GO:0030593	Biological process	Neutrophil chemotaxis	IBA	21873635
GO:0030593	Biological process	Neutrophil chemotaxis	IDA	8399143
GO:0030593	Biological process	Neutrophil chemotaxis	IGI	11564821
GO:0030595	Biological process	Leukocyte chemotaxis	IBA	21873635
GO:0031623	Biological process	Receptor internalization	IDA	10734056
GO:0034976	Biological process	Response to endoplasmic reticulum stress	IDA	20829347
GO:0035556	Biological process	Intracellular signal transduction	IDA	10734056
GO:0042119	Biological process	Neutrophil activation	IDA	8399143
GO:0042119	Biological process	Neutrophil activation	TAS	11483765
GO:0044344	Biological process	Cellular response to fibroblast growth factor stimulus	IEP	9407497
GO:0045091	Biological process	Regulation of single stranded viral RNA replication via double stranded DNA intermediate	IDA	11483765
GO:0045744	Biological process	Negative regulation of G protein-coupled receptor signaling pathway	IDA	10734056
GO:0045766	Biological process	Positive regulation of angiogenesis	IDA	19035451
GO:0048566	Biological process	Embryonic digestive tract development	IEP	20875417
GO:0050930	Biological process	Induction of positive chemotaxis	IGI	11564821
GO:0061844	Biological process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IBA	21873635
GO:0070098	Biological process	Chemokine-mediated signaling pathway	IBA	21873635
GO:0071222	Biological process	Cellular response to lipopolysaccharide	IBA	21873635
GO:0071222	Biological process	Cellular response to lipopolysaccharide	IDA	19912257
GO:0071347	Biological process	Cellular response to interleukin-1	IEP	9407497
GO:0071356	Biological process	Cellular response to tumor necrosis factor	IEP	9407497
GO:0090023	Biological process	Positive regulation of neutrophil chemotaxis	TAS	1699135
GO:2000535	Biological process	Regulation of entry of bacterium into host cell	IMP	26829648
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0005153	Molecular function	Interleukin-8 receptor binding	IPI	1840701
GO:0005515	Molecular function	Protein binding	IPI	10880251, 22904195, 23597562, 24501198, 26829648, 28381538
GO:0008009	Molecular function	Chemokine activity	IBA	21873635
GO:0008009	Molecular function	Chemokine activity	IDA	8399143
GO:0008009	Molecular function	Chemokine activity	TAS	12782716

Protein Information

Protein Name

Interleukin-8, T-cell chemotactic factor, alveolar macrophage chemotactic factor I, beta endothelial cell-derived neutrophil activating peptide, beta-thromboglobulin-like protein, chemokine (C-X-C motif) ligand 8, emoctakin, granulocyte chemotactic protein 1, interleukin 8, lung giant cell carcinoma-derived chemotactic protein, lymphocyte derived neutrophil activating peptide, monocyte-derived neutrophil chemotactic factor, monocyte-derived neutrophil-activating peptide, neutrophil-activating peptide 1, small inducible cytokine subfamily B, member 8, tumor necrosis factor-induced gene 1

Function

IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.

Refseq Proteins

NP_000575.1, NP_001341769.1

UniProt

P10145

PDB

1ILP, 1ILQ, 1ROD, 1ICW, 1IKL, 1IKM, 1IL8, 1QE6, 2IL8, 3IL8, 4XDX, 5D14, 5WDZ

Pathways
	KEGG	Reactome
	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway NF-kappa B signaling pathway Phospholipase D signaling pathway Cellular senescence Toll-like receptor signaling pathway NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway IL-17 signaling pathway Non-alcoholic fatty liver disease (NAFLD) AGE-RAGE signaling pathway in diabetic complications Epithelial cell signaling in Helicobacter pylori infection Shigellosis Salmonella infection Pertussis Legionellosis Yersinia infection Chagas disease (American trypanosomiasis) Malaria Amoebiasis Hepatitis B Human cytomegalovirus infection Influenza A Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Transcriptional misregulation in cancer Bladder cancer Rheumatoid arthritis	Senescence-Associated Secretory Phenotype (SASP) Peptide ligand-binding receptors Chemokine receptors bind chemokines ATF4 activates genes in response to endoplasmic reticulum stress G alpha (i) signalling events Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling

Associated Diseases

Show/Hide all(14 )

Disease group	Disease Name	References
Cardiovascular Diseases
Cardiovascular Diseases	Angina pectoris	10660968
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
	Down Syndrome	16289943
	Wilson Disease	25002079
Digestive System Diseases
	Colitis	12133438, 15955209
	Gastroesophageal reflux disease	18193101, 20616304
	Esophagitis	18193101
	Cholestasis	21224055
	Hepatitis, Alcoholic	26220752
	Fatty Liver	23348005
Ear Or Mastoid Diseases
Ear Or Mastoid Diseases	Meniere Disease	28787010
Endocrine System Diseases
Endocrine System Diseases	PCOS	29779926, 29859385, 29648472
Eye Diseases
Eye Diseases	Keratitis	23661603
Immune System Diseases
	Pemphigus	11359455
	Rheumatoid Arthritis	19192274, 17379860
	Behcet Syndrome	8712863
Musculoskeletal Diseases
Musculoskeletal Diseases	Arthritis, Psoriatic	19732956
Neoplasms
	Breast Cancer	17516992, 16298037
	Colorectal Cancer	20065508
	Thyroid Cancer	26037280
	Endometrial Cancer	17380299
	Prostate cancer	17606477, 16606632
	Lung Cancer	15956251, 25162674
	Pancreatic Neoplasm	18307536
	Glioblastoma Multiforme	16356833
	Ovarian Cancer	21742513, 19401270
	Stomach Cancer	15492468, 15723263
	Glioblastoma	16356833
	Adenocarcinoma	18307536
	Gastric Cancer	15492468, 15723263
	Barrett Esophagus	15387324
	Bladder Cancer	22015448
	Liver Cancer	12432545
	Cribriform Carcinoma	18307536
	Carcinoma	18307536, 15956251
	Barrett Epithelium	15387324
Psychiatric/Brain disorders
	Mental Depression	25315113, 22921153, 22990943, 23149083, 18086782, 17898993
	Delirium	21851175, 23385102
	Bipolar Disorder	25855618
	Obstructive Sleep Apnea	26201496, 27693879, 26505576, 15325007
Renal Disorder
	Nephritis	9403216, 10910440
	Glomerulonephritis	9403216, 10910440
Reproductive disorders
Reproductive disorders	Preeclampsia	27935985, 26711734, 29658087, 21430233, 20220108, 30007972
Respiratory Tract Diseases
	Airway Obstruction	15337792, 28864214, 23099361
	Pulmonary Fibrosis	17894541, 17266442
	Chronic Obstructive Pulmonary Disease	15337792, 23099361, 28864214
	Pneumonia	24894820
Skin and Connective Tissue Diseases
	Leishmaniasis	20102417
	Lichenoid Eruptions	18393961

References

Show/Hide all(3)

PubMed ID	Associated gene/s	Associated condition	Genetic Mutation	Diagnostic Criteria	Association with PCOS	Ethnicity	Conclusion
29648472	GAS5	PCOS, insulin resistance (IR),		Rotterdam consensus	Direct	76 serum samples was collected from patients who underwent first GnRH antagonist protocol In Vitro Fertilization/ Intracytoplasmic Sperm Injection (IVF/ICSI) [non-PCOS and PCOS patients]	Elevated IL-18 expression and downregulation of GAS5 in serums might contribute to IR in PCOS patients.
29779926	PF4	PCOS, Abnormal folliculogenesis		2003 Rotterdam criteria	Related	13 patients with PCOS, 11 normo-ovulatory patients as control	Our study provides the first evidence of the pathophysiologic contribution of the well-known angiostatic protein, PF4, on human reproductive biology. The increase of the intrafollicular PF4 and its anti-permeability effect might affect the formation of FF and folliculogenesis in PCOS.
29859385	IL-1, TGFB, VEGF, TNFA	PCOS, hyperandrogenism, menstrual dysfunction, impaired fertility, dyslipidemia, inflammationinflammation, oxidative stress, insulin resistance, hypertension, T2DM, Cardiovascular diseases, , depression, anxiety, Insulin resistance, abdominal obesity,		Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group, 2004	Related	60 women with PCOS	Overall, the co-administration of vitamin D and omega-3 fatty acid for 12 weeks had beneficial effects on mental health parameters, serum total testosterone, hs-CRP, plasma TAC and MDA levels, and gene expression of IL-1 and VEGF among women with PCOS