| |
| |
Gene Symbol |
CYBB |
| |
Aliases |
AMCBX2, CGD, GP91-1, GP91-PHOX, GP91PHOX, IMD34, NOX2, p91-PHOX |
| |
Entrez Gene ID |
|
| |
Gene Name |
Cytochrome b-245 beta chain |
| |
Chromosomal Location |
Xp21.1-p11.4 |
| |
HGNC ID |
|
| |
Summary |
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]
|
| |
RefSeq DNA |
|
| |
RefSeq mRNA |
|
| |
e!Ensembl
|
| Protein Information |
| |
Protein Name |
Cytochrome b-245 heavy chain, CGD91-phox, NADPH oxidase 2, cytochrome b(558) subunit beta, cytochrome b-245 beta polypeptide, cytochrome b558 subunit beta, heme-binding membrane glycoprotein gp91phox, neutrophil cytochrome b 91 kDa polypeptide, p22 phagocyte B-cytochrome, superoxide-generating NADPH oxidase heavy chain subunit |
| |
Function |
|
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc |
|
| |
|
|
| |
UniProt |
|
| |
PDB |
|
|
|
|
|
|
| |
| |
Associated Diseases
| Disease group | Disease Name | References |
| Cardiovascular Diseases |
| Hypertensive disease |
|
| Myocardial Failure |
|
| Heart Failure |
|
| Endocrine System Diseases |
| Diabetes Mellitus |
|
| PCOS |
|
| Immune System Diseases |
| Granulomatous Disease |
26453586, 24999735, 22924737, 8634410, 15308575, 28492532, 20724480, 1710153, 20729109, 8900212, 21190454, 15338276, 1347621, 10914676, 11462241, 12589359, 22876374, 11997083, 25741868, 9585602, 8182143, 8916969, 22540226, 18773283, 8101486, 22125116, 9888386, 9794, 21278736, 11498749, 11122248 |
| Nervous System Diseases |
| Brain Infarction |
|
| Renal Disorder |
| Kidney Failure |
|
|
|
References |
| |
| |
| Lai Qiaohong, Xiang Wenpei, Li Qing, Zhang Hanwang, Li Yufeng, Zhu Guijin, Xiong Chengliang, Jin Lei |
| Reproductive Medicine Center, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430030, China. lqh74@126.com.| Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.| Reproductive Medicine Center, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430030, China.| Reproductive Medicine Center, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430030, China.| Reproductive Medicine Center, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430030, China.| Reproductive Medicine Center, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430030, China.| Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.| Reproductive Medicine Center, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430030, China. ljin@tjh.tjmu.edu.cn. |
| Front Med. 2018 Oct;12(5):518-524. doi: 10.1007/s11684-017-0575-y. Epub 2017 Dec |
Abstract
The increased levels of intracellular reactive oxygen species (ROS) in granulosa cells (GCs) may affect the pregnancy results in women with polycystic ovary syndrome (PCOS). In this study, we compared the in vitro fertilization and embryo transfer (IVF-ET) results of 22 patients with PCOS and 25 patients with tubal factor infertility and detected the ROS levels in the GCs of these two groups. Results showed that the PCOS group had significantly larger follicles on the administration day for human chorionic gonadotropin than the tubal factor group (P < 0.05); however, the number of retrieved oocytes was not significantly different between the two groups (P > 0.05). PCOS group had slightly lower fertilization, cleavage, grade I/II embryo, clinical pregnancy, and implantation rates and higher miscarriage rate than the tubal factor group (P > 0.05). We further found a significantly higher ROS level of GCs in the PCOS group than in the tubal factor group (P < 0.05). The increased ROS levels in GCs caused GC apoptosis, whereas NADPH oxidase 2 (NOX2) specific inhibitors (diphenyleneiodonium and apocynin) significantly reduced the ROS production in the PCOS group. In conclusion, the increased ROS expression levels in PCOS GCs greatly induced cell apoptosis, which further affected the oocyte quality and reduced the positive IVF-ET pregnancy results of women with PCOS. NADPH oxidase pathway may be involved in the mechanism of ROS production in GCs of women with PCOS. |
|
|
|
| |
| © 2019, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
Tel: 91-22-24192104, Fax No: 91-22-24139412
|
