DACT1: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

DACT1

Aliases

DAPPER, DAPPER1, DPR1, FRODO, HDPR1, TBS2, THYEX3

Entrez Gene ID

51339

Gene Name

Dishevelled binding antagonist of beta catenin 1

Chromosomal Location

14q23.1

HGNC ID

HGNC:17748

Summary

The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

RefSeq DNA

NG_032025.1

RefSeq mRNA

NM_016651.6, NR_046093.2, NR_046095.1, NM_001079520.2

e!Ensembl

Gene	ENSG00000165617
Transcript	ENST00000556859, ENST00000421793, ENST00000395153, ENST00000335867, ENST00000541264
Protein	ENSP00000451598, ENSP00000404297, ENSP00000378582, ENSP00000337439, ENSP00000442850

Gene Ontology (GO)

Show/Hide all(36 )

GO ID	Ontology	Function	Evidence	Reference
GO:0000122	Biological process	Negative regulation of transcription by RNA polymerase II	IDA	18936100
GO:0021915	Biological process	Neural tube development	IMP	22610794
GO:0030111	Biological process	Regulation of Wnt signaling pathway	IBA	21873635
GO:0030177	Biological process	Positive regulation of Wnt signaling pathway	IDA	21262972
GO:0030178	Biological process	Negative regulation of Wnt signaling pathway	IDA	16446366, 17197390
GO:0030178	Biological process	Negative regulation of Wnt signaling pathway	IGI	16446366
GO:0030178	Biological process	Negative regulation of Wnt signaling pathway	IMP	18936100
GO:0031647	Biological process	Regulation of protein stability	IDA	21262972
GO:0032091	Biological process	Negative regulation of protein binding	IGI	18936100
GO:0032092	Biological process	Positive regulation of protein binding	IGI	18936100
GO:0045732	Biological process	Positive regulation of protein catabolic process	IDA	16446366
GO:0046329	Biological process	Negative regulation of JNK cascade	IDA	17197390
GO:0060828	Biological process	Regulation of canonical Wnt signaling pathway	IMP	18936100
GO:0090090	Biological process	Negative regulation of canonical Wnt signaling pathway	IGI	18936100
GO:0090090	Biological process	Negative regulation of canonical Wnt signaling pathway	IMP	22610794
GO:0090263	Biological process	Positive regulation of canonical Wnt signaling pathway	IMP	15580286
GO:1900107	Biological process	Regulation of nodal signaling pathway	IDA	17197390
GO:1903364	Biological process	Positive regulation of cellular protein catabolic process	IDA	16446366
GO:1903364	Biological process	Positive regulation of cellular protein catabolic process	IMP	18936100
GO:1904864	Biological process	Negative regulation of beta-catenin-TCF complex assembly	IDA	18936100
GO:2000095	Biological process	Regulation of Wnt signaling pathway, planar cell polarity pathway	IBA	21873635
GO:2000134	Biological process	Negative regulation of G1/S transition of mitotic cell cycle	IDA	18936100
GO:0005634	Cellular component	Nucleus	IDA	18936100
GO:0005737	Cellular component	Cytoplasm	IBA	21873635
GO:0005737	Cellular component	Cytoplasm	IDA	16446366, 18936100, 22610794
GO:0030877	Cellular component	Beta-catenin destruction complex	IDA	22470507
GO:0001085	Molecular function	RNA polymerase II transcription factor binding	IPI	18936100
GO:0005080	Molecular function	Protein kinase C binding	IBA	21873635
GO:0005515	Molecular function	Protein binding	IPI	16446366, 21262972, 22470507, 22610794
GO:0008013	Molecular function	Beta-catenin binding	IBA	21873635
GO:0008013	Molecular function	Beta-catenin binding	IDA	18936100, 22470507
GO:0008013	Molecular function	Beta-catenin binding	IPI	18936100
GO:0042826	Molecular function	Histone deacetylase binding	IPI	18936100
GO:0051018	Molecular function	Protein kinase A binding	IBA	21873635
GO:0051018	Molecular function	Protein kinase A binding	IDA	21262972
GO:0070097	Molecular function	Delta-catenin binding	IBA	21873635

Protein Information

Protein Name

Dapper homolog 1, dapper antagonist of catenin 1, dapper, antagonist of beta-catenin, homolog 1, hepatocellular carcinoma novel gene 3 protein, heptacellular carcinoma novel gene 3

Function

Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway (By similarity). The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling. May be involved in positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines.

Refseq Proteins

NP_057735.2, , NP_001072988.1

UniProt

Q9NYF0

Pfam

Pfam Accession	Pfam ID
PF15268	Dapper

DACT1

Gene expression microarray profiles of cumulus cells in lean and overweight-obese polycystic ovary syndrome patients.